Ligand trypanothione

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Basic Ligand Information

Molecular Structure
Picture of trypanothione (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C27H49N9O10S2
trypanothione
PHDOXVGRXXAYEB-VJANTYMQSA-N
Synonyms:
2-amino-4-[1-([[3-(4-{2-[2-(4-amino-4-carboxy-butyrylamino)-3-mercapto-propionylamino]-acetylamino]-butylamino)-propylcarbamoyl]-methyl}-carbamoyl)-2-mercapto-ethylcarbamoyl]-butyric acid, N1,N8-bis(glutathionyl)spermidine, N1,N8-bis-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine, reduced trypanothione
Pathway Source
Pathways


Show all pahtways known for Show all BRENDA pathways known for trypanothione

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

In Vivo Product in Enzyme-catalyzed Reactions (16 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
trypanothione + NADPH = reduced trypanothione + NADP+
show the reaction diagram
-
trypanothione + H2O = glutathione + glutathionylspermidine
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (34 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
trypanothione + NADPH = reduced trypanothione + NADP+
show the reaction diagram
-
2 glutathione + spermidine + 2 ATP = N1,N8-bis(glutathionyl)spermidine + 2 ADP + 2 phosphate
show the reaction diagram
-
-

Inhibitor in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
-
-
competitive feedback inhibition
-

3D Structure of Enzyme-Ligand-Complex (PDB) (12 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (8 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (12 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

Ki Value (4 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for trypanothione

ChEBI
PubChem
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PubChem