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Purification of glutathionylspermidine and trypanothione synthetase from Crithidia fasciculata
1992
Smith, K.; Nadeau, K.; Bradley, M.; Walsh, C.; Fairlamb, A.H.
Protein Sci.
1
874-883
Mechanism of inhibition of trypanothione reductase and glutathione reductase by trivalent organic arsenicals
1994
Cunningham, M.L.; Zvelebil, M.J.J.M.; Fairlamb, A.H.
Eur. J. Biochem.
221
285-295
NADPH-dependent disulphide reductases
1989
Krauth-Siegel, R.L.; Jockers-Scheruebl, M.C.; Becker, K.; Schirmer, R.H.
Biochem. Soc. Trans.
17
315-317
Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity
1997
Stoll, V.S.; Simpson, S.J.; Krauth-Siegel, R.L.; Walsh, C.T.; Pai, E.F.
Biochemistry
36
6437-6447
Evidence for the co-existence of glutathione reductase and trypanothione reductase in the non-trypanosomatid Euglenozoa: Euglena gracilis Z
1999
Montrichard, F.; Le Guen, F.; Laval-Martin, D.L.; Davioud-Charvet, E.
FEBS Lett.
442
29-33
Ajoene is an inhibitor and subversive substrate of human glutathione reductase and Trypanosoma cruzi trypanothione reductase: crystallographic, kinetic, and spectroscopic studies
1999
Gallwitz, H.; Bonse, S.; Martinez-Cruz, A.; Schlichting, I.; Schumacher, K.; Krauth-Siegel, R.L.
J. Med. Chem.
42
364-372
-
Cloning by expression of a cDNA corresponding to Leishmania donovani trypanothione reductase
1989
Taylor, M.C.; Chapman, C.J.; Kelly, J.M.; Fairlamb, A.H.; Miles, M.A.
Biochem. Soc. Trans.
17
579-580
Expression of Trypanosoma congolense trypanothione reductase in Escherichia coli: overproduction, purification, and characterization
1989
Sullivan, F.X.; Shames, S.L.; Walsh, C.T.
Biochemistry
28
4986-4992
Trypanothione is the primary target for arsenical drugs against African trypanosomes
1989
Fairlamb, A.H.; Henderson, G.B.; Cerami, A.
Proc. Natl. Acad. Sci. USA
86
2607-2611
Trypanothione reductase from Trypanosoma cruzi. Catalytic properties of the enzyme and inhibition studies with trypanocidal compounds
1989
Jockers-Scheruebl, M.C.; Schirmer, R.H.; Krauth-Siegel, R.L.
Eur. J. Biochem.
180
267-272
Subversive substrates for the enzyme trypanothione disulfide reductase: alternative approach to chemotherapy of Chagas disease
1988
Henderson, G.B.; Ulrich, P.; Fairlamb, A.H.; Rosenberg, I.; Pereira, M.; Sela, M.; Cerami, A.
Proc. Natl. Acad. Sci. USA
85
5374-5378
Trypanothione reductase of Trypanosoma congolense: gene isolation, primary sequence determination, and comparison to glutathione reductase
1988
Shames, S.L.; Kimmel, B.E.; Peoples, O.P.; Agabian, N.; Walsh, C.T.
Biochemistry
27
5014-5019
Substrate specificity of the flavoprotein trypanothione disulfide reductase from Crithidia fasciculata
1987
Henderson, G.B.; Fairlamb, A.H.; Ulrich, P.; Cerami, A.
Biochemistry
26
3023-3027
Trypanothione reductase from Trypanosoma cruzi. Purification and characterization of the crystalline enzyme
1987
Krauth-Siegel, R.L.; Enders, B.; Henderson, G.B.; Fairlamb, A.H.; Schirmer, R.H.
Eur. J. Biochem.
164
123-128
Purification and characterization of trypanothione reductase from Crithidia fasciculata, a newly discovered member of the family of disulfide-containing flavoprotein reductases
1986
Shames, S.L.; Fairlamb, A.H.; Cerami, A.; Walsh, C.T.
Biochemistry
25
3519-3526
Inhibition of trypanothione reductase by substrate analogues
2000
Garrard, E.A.; Borman, E.C.; Cook, B.N.; Pike, E.J.; Alberg, D.G.
Org. Lett.
2
3639-3642
Nitrofuran drugs as common subversive substrates of Trypanosoma cruzi lipoamide dehydrogenase and trypanothione reductase
1999
Blumenstiel, K.; Schoneck, R.; Yardley, V.; Croft, S.L.; Krauth-Siegel, R.L.
Biochem. Pharmacol.
58
1791-1799
Catalytic and potentiometric characterization of E201D and E201Q mutants of Trypanosoma congolense trypanothione reductase
1995
Zheng, R.; Cenas, N.; Blanchard, J.S.
Biochemistry
34
12697-12703
Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors
1999
Bond, C.S.; Zhang, Y.; Berriman, M.; Cunningham, M.L.; Fairlamb, A.H.; Hunter, W.N.
Structure
7
81-89
Synthesis of 5,5'-dithiobis(2-nitrobenzamides) as alternative substrates for trypanothione reductase and thioredoxin reductase: a microtiter colorimetric assay for inhibitor screening
1999
Davioud-Charvet, E.; Becker, K.; Landry, V.; Gromer, S.; Loge, C.; Sergheraert, C.
Anal. Biochem.
268
1-8
Phenotype of recombinant Leishmania donovani and Trypanosoma cruzi which over-express trypanothione reductase. Sensitivity towards agents that are thought to induce oxidative stress
1993
Kelly, J.M.; Taylor, M.C.; Smith, K.; Hunter, K.J.; Fairlamb, A.H.
Eur. J. Biochem.
218
29-37
-
Kukoamine A and other hydrophobic acylpolyamines: potent and selective inhibitors of Crithidia fasciculata trypanothione reductase
1995
Ponasik, J.A.; Strickland, C.; Faerman, C.; Savvides, S.; Karplus, P.A.; Ganem, B.
Biochem. J.
311
371-375
Trypanothione reductase from Leishmania donovani. Purification, characterization and inhibition by trivalent antimonials
1995
Cunningham, M.L.; Fairlamb, A.H.
Eur. J. Biochem.
230
460-468
Site-directed mutagenesis of the redox-active cysteines of Trypanosoma cruzi trypanothione reductase
1995
Borges, A.; Cunningham, M.L.; Tovar, J.; Fairlamb, A.H.
Eur. J. Biochem.
228
745-752
The glutamyl binding site of trypanothione reductase from Crithidia fasciculata: enzyme kinetic properties of.gamma-glutamyl-modified substrate analogs
1993
El-Waer, A.F.; Smith, K.; McKie, J.H.; Benson, T.; Fairlamb, A.H.; Douglas, K.T.
Biochim. Biophys. Acta
1203
93-98
2- And 3-substituted 1,4-naphthoquinone derivatives as subversive substrates of trypanothione reductase and lipoamide dehydrogenase from Trypanosoma cruzi: Synthesis and correlation between redox cycling activities and in vitro cytotoxicity
2001
Salmon-Chemin, L.; Buisine, E.; Yardley, V.; Kohler, S.; Debreu, M.A.; Landry, V.; Sergheraert, C.; Croft, S.L.; Krauth-Siegel, R.L.; Davioud-Charvet, E.
J. Med. Chem.
44
548-565
(2,2':6',2''-Terpyridine)platinum(II) complexes are irreversible inhibitors of Trypanosoma cruzi trypanothione reductase but not of human glutathione reductase
2000
Bonse, S.; Richards, J.M.; Ross, S.A.; Lowe, G.; Krauth-Siegel, R.L.
J. Med. Chem.
43
4812-4821
Inhibition of Trypanosoma cruzi trypanothione reductase by acridines: kinetic studies and structure-activity relationships
1999
Bonse, S.; Santelli-Rouvier, C.; Barbe, J.; Krauth-Siegel, R.L.
J. Med. Chem.
42
5448-5454
Evidence that trypanothione reductase is an essential enzyme in Leishmania by targeted replacement of the tryA gene locus
1998
Tovar, J.; Wilkinson, S.; Mottram, J.C.; Fairlamb, A.H.
Mol. Microbiol.
29
653-660
Trypanocidal bisbenzylisoquinoline alkaloids are inhibitors of trypanothione reductase
1998
Fournet, A.; Inchausti, A.; Yaluff, G.; Royas De Arias, A.; Guinaudeau, H.; Bruneton, J.; Breidenbach, M.A.; Karplus, P.A.; Faerman, C.H.
J. Enzyme Inhib.
13
1-9
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata
2002
Oza, S.L.; Ariyanayagam, M.R.; Fairlamb, A.H.
Biochem. J.
364
679-686
-
Detection by HPLC of a trypanothione synthetase activity in vitro from Entamoeba histolytica
1999
Ondarza, R.N.; Hernandez, E.; Iturbe, A.; Hurtado, G.; Tamayo, E.M.
Biotechnol. Appl. Biochem.
30
41-45
A Single Enzyme Catalyses Formation of Trypanothione from Glutathione and Spermidine in Trypanosoma cruzi
2002
Oza, S.L.; Tetaud, E.; Ariyanayagam, M.R.; Warnon, S.S.; Fairlamb, A.H.
J. Biol. Chem.
277
35853-35861
Glyoxalase II of African trypanosomes is trypanothione-dependent
2004
Irsch, T.; Krauth-Siegel, R.L.
J. Biol. Chem.
279
22209-22217
Engineering the substrate specificity of glutathione reductase toward that of trypanothione reduction
1991
Henderson, G.B.; Murgolo, N.J.; Kuriyan, J.; Osapay, K.; Kominos, D.; Berry, A.; Scrutton, N.S.; Hinchliffe, N.W.; Perham, R.N.; Cerami, A.
Proc. Natl. Acad. Sci. USA
88
8769-8773
Glyoxalase I from Leishmania donovani: a potential target for anti-parasite drug
2005
Padmanabhan, P.K.; Mukherjee, A.; Singh, S.; Chattopadhyaya, S.; Gowri, V.S.; Myler, P.J.; Srinivasan, N.; Madhubala, R.
Biochem. Biophys. Res. Commun.
337
1237-1248
Discovery of 2-iminobenzimidazoles as a new class of trypanothione reductase inhibitor by high-throughput screening
2006
Holloway, G.A.; Baell, J.B.; Fairlamb, A.H.; Novello, P.M.; Parisot, J.P.; Richardson, J.; Watson, K.G.; Street, I.P.
Bioorg. Med. Chem. Lett.
17
1422-1427
Trypanothione-dependent glyoxalase I in Trypanosoma cruzi
2006
Greig, N.; Wyllie, S.; Vickers, T.J.; Fairlamb, A.H.
Biochem. J.
400
217-223
Specificity of the trypanothione-dependent Leishmania major glyoxalase I: structure and biochemical comparison with the human enzyme
2006
Ariza, A.; Vickers, T.J.; Greig, N.; Armour, K.A.; Dixon, M.J.; Eggleston, I.M.; Fairlamb, A.H.; Bond, C.S.
Mol. Microbiol.
59
1239-1248
Cloning and expression of trypanothione reductase from a New World Leishmania species
2008
Castro-Pinto, D.B.; Genestra, M.; Menezes, G.B.; Waghabi, M.; Goncalves, A.; De Nigris Del Cistia, C.; SantAnna, C.M.; Leon, L.L.; Mendonca-Lima, L.
Arch. Microbiol.
189
375-384
-
Inhibition of trypanothione reductase and glutathione reductase by ferrocenic 4-aminoquinoline ureas
2008
Blackie, M.A.; Saravanamuthu, A.; Fairlamb, A.H.; Chibale, K.
ARKIVOC
2008
52-60
The use of natural product scaffolds as leads in the search for trypanothione reductase inhibitors
2008
Galarreta, B.C.; Sifuentes, R.; Carrillo, A.K.; Sanchez, L.; Amado, M.d.e.l.R.; Maruenda, H.
Bioorg. Med. Chem.
16
6689-6695
High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity
2007
Martyn, D.C.; Jones, D.C.; Fairlamb, A.H.; Clardy, J.
Bioorg. Med. Chem. Lett.
17
1280-1283
Betraying the parasites redox system: diaryl sulfide-based inhibitors of trypanothione reductase: subversive substrates and antitrypanosomal properties
2007
Stump, B.; Kaiser, M.; Brun, R.; Krauth-Siegel, R.L.; Diederich, F.
ChemMedChem
2
1708-1712
Altenusin, a biphenyl isolated from the endophytic fungus Alternaria sp., inhibits trypanothione reductase from Trypanosoma cruzi
2008
Cota, B.B.; Rosa, L.H.; Caligiorne, R.B.; Rabello, A.L.; Almeida Alves, T.M.; Rosa, C.A.; Zani, C.L.
FEMS Microbiol. Lett.
285
177-182
Leishmania amazonensis trypanothione reductase: evaluation of the effect of glutathione analogs on parasite growth, infectivity and enzyme activity
2007
Castro-Pinto, D.B.; Lima, E.L.; Cunha, A.S.; Genestra, M.; De Leo, R.M.; Monteiro, F.; Leon, L.L.
J. Enzyme Inhib. Med. Chem.
22
71-75
A potent trypanocidal component from the fungus Lentinus strigosus inhibits trypanothione reductase and modulates PBMC proliferation
2008
Cota, B.B.; Rosa, L.H.; Fagundes, E.M.; Martins-Filho, O.A.; Correa-Oliveira, R.; Romanha, A.J.; Rosa, C.A.; Zani, C.L.
Mem. Inst. Oswaldo Cruz
103
263-270
-
Interaction energies of nitrofurans with trypanothione reductase and glutathione reductase studied by molecular docking
2007
Iribarne, F.; Gonzalez, M.; Cerecetto, H.; Aguilera, S.; Tapia, O.; Paulino, M.
Theochem
818
7-22
Microbial glyoxalase enzymes: metalloenzymes controlling cellular levels of methylglyoxal
2008
Sukdeo, N.; Honek, J.F.
Drug Metabol. Drug Interact.
23
29-50
A comparative study of methylglyoxal metabolism in trypanosomatids
2009
Greig, N.; Wyllie, S.; Patterson, S.; Fairlamb, A.H.
FEBS J.
276
376-386
Leishmania trypanothione synthetase-amidase structure reveals a basis for regulation of conflicting synthetic and hydrolytic activities
2008
Fyfe, P.K.; Oza, S.L.; Fairlamb, A.H.; Hunter, W.N.
J. Biol. Chem.
283
17672-17680
Synthesis and evaluation of 1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) analogues as inhibitors of trypanothione reductase
2009
Patterson, S.; Jones, D.C.; Shanks, E.J.; Frearson, J.A.; Gilbert, I.H.; Wyatt, P.G.; Fairlamb, A.H.
ChemMedChem
4
1341-1353
Comparative structural, kinetic and inhibitor studies of Trypanosoma brucei trypanothione reductase with T. cruzi
2010
Jones, D.C.; Ariza, A.; Chow, W.H.; Oza, S.L.; Fairlamb, A.H.
Mol. Biochem. Parasitol.
169
12-19
Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of glyoxalase I from Leishmania infantum
2010
Barata, L.; Sousa Silva, M.; Schuldt, L.; da Costa, G.; Tomas, A.M.; Ferreira, A.E.; Weiss, M.S.; Ponces Freire, A.; Cordeiro, C.
Acta Crystallogr. Sect. F
66
571-574
Dissecting the catalytic mechanism of Trypanosoma brucei trypanothione synthetase by kinetic analysis and computational modeling
2013
Leroux, A.E.; Haanstra, J.R.; Bakker, B.M.; Krauth-Siegel, R.L.
J. Biol. Chem.
288
23751-23764
Glyoxalase diversity in parasitic protists
2014
Deponte, M.
Biochem. Soc. Trans.
42
473-478
Bacterial glyoxalase I enzymes: structural and biochemical investigations
2014
Honek, J.F.
Biochem. Soc. Trans.
42
479-484