Ligand glycerate

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Basic Ligand Information

Molecular Structure
Picture of glycerate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C3H6O4
glycerate
RBNPOMFGQQGHHO-UHFFFAOYSA-N
Synonyms:
2,3-dihydroxypropanoate, 2,3-dihydroxypropanoic acid, alpha,beta-dihydroxypropionic acid, D,L-glyceric acid, DL-glycerate, glyceric acid

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
DL-glycerate + O2 = ? + H2O2
show the reaction diagram
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ADP-glucose + glycerate = 2-O-(alpha-D-glucopyranosyl)-D-glycerate + ADP
show the reaction diagram
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ATP + glycerate = ADP + 3-phospho-(R)-glycerate
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
glyceraldehyde + H2O + oxidized ferredoxin = glycerate + H+ + reduced ferredoxin
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
DL-glycerate + NAD+ = 3-hydroxypyruvate + NADH + H+
show the reaction diagram
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glycerate + O2 = hydroxypyruvate + H2O2
show the reaction diagram
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DL-glycerate + H2O + NAD+ = ? + NH3 + NADH + H+
show the reaction diagram
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ADP-glucose + glycerate = 2-O-(alpha-D-glucopyranosyl)-D-glycerate + ADP
show the reaction diagram
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ATP + glycerate = ADP + 3-phospho-(R)-glycerate
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (59 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
hydroxypyruvate + NADPH = 2,3-dihydroxypropanoate + NADP+
show the reaction diagram
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hydroxypyruvate + NADPH + H+ = 2,3-dihydroxypropanoate + NADP+
show the reaction diagram
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hydroxypyruvate + NAD(P)H + H+ = glycerate + NAD(P)+
show the reaction diagram
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hydroxypyruvate + NAD(P)H + H+ = glycerate + NAD(P)+
show the reaction diagram
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glyceraldehyde + NAD+ + H2O = glycerate + NADH + H+
show the reaction diagram
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DL-glyceraldehyde + NAD+ + H2O = glycerate + NADH
show the reaction diagram
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DL-glyceraldehyde + NAD+ + H2O = 2,3-dihydroxypropanoic acid + NADH + H+
show the reaction diagram
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DL-glyceraldehyde + NAD+ + H2O = glycerate + NADH
show the reaction diagram
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glyceraldehyde + NAD+ + H2O = glycerate + NADH
show the reaction diagram
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DL-glyceraldehyde + NADP+ + H2O = glycerate + NADPH + H+
show the reaction diagram
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DL-glyceraldehyde + NAD+ + H2O = DL-glycerate + NADH + H+
show the reaction diagram
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glyceraldehyde + NAD+ + H2O = glycerate + NADH + H+
show the reaction diagram
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DL-glyceraldehyde + 2,6-dichlorophenolindophenol + H2O = glycerate + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
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3-phosphoglycerate + H2O = 2,3-dihydroxypropanoic acid + phosphate
show the reaction diagram
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3-phosphoglycerate + H2O = glyceric acid + phosphate
show the reaction diagram
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3-phosphoglycerate + H2O = glycerate + phosphate
show the reaction diagram
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glycerate 2-phosphate + H2O = glycerate + phosphate
show the reaction diagram
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3-phosphoglycerate + H2O = glycerate + phosphate
show the reaction diagram
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2-chloro-3-hydroxypropionate + H2O = glycerate + HCl
show the reaction diagram
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2-chloro-3-hydroxypropionate + H2O = glycerate + HCl
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
5 mM, 244% of initial activity
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Inhibitor in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
strong inhibition
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inhibits at physiological concentrations
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D-glycerate, L-glycerate and DL-glycerate, weak noncompetitive
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (4 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
1.04
-
pH 8.0
5.8
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pH 11.0, 37°C, recombinant His-tagged wild-type enzyme

KM Value (10 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
2.6
-
-
19.8
-
pH 11.0, 37°C, recombinant His-tagged wild-type enzyme
0.15
-
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References & Links

Links to other databases for glycerate

ChEBI
PubChem
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PubChem