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Ligand D-threonine

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Basic Ligand Information

Molecular Formula
BRENDA Name
InChIKey
C4H9NO3
D-threonine
AYFVYJQAPQTCCC-ZJRLKYRESA-N
Synonyms:
D-Thr
Pathway Source
Pathways

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acetyl-CoA + D-threonine = CoA + N-acetyl-D-threonine
show the reaction diagram
-
D-threonine + 2-oxoglutarate = 2-oxobutanoate + D-glutamate
show the reaction diagram
-
D-threonine = glycine + acetaldehyde
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-threonine = D-threonine
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (32 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-threonine + NADP+ = D-2-amino-3-oxobutanoic acid + NADPH
show the reaction diagram
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D-threonine + NADP+ = ?
show the reaction diagram
-
D-threonine + NAD+ = ?
show the reaction diagram
-
D-threonine + H2O + oxidized acceptor = 3-hydroxy-2-oxobutanoate + NH3 + reduced acceptor
show the reaction diagram
-
D-threonine + oxidized 2,6-dichloroindophenol + H2O = 3-hydroxy-2-oxobutanoate + NH3 + reduced 2,6-dichloroindophenol
show the reaction diagram
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acetyl-CoA + D-threonine = CoA + N-acetyl-D-threonine
show the reaction diagram
-
D-threonine = glycine + acetaldehyde
show the reaction diagram
-
D-threonine = glycine + acetaldehyde
show the reaction diagram
-
D-threonine = ?
show the reaction diagram
-
D-threonine = 2-oxobutyrate + NH3
show the reaction diagram
-
D-threonine = 2-oxobutanoate + NH3
show the reaction diagram
-
D-threonine = L-threonine
show the reaction diagram
-
D-alanine + D-threonine + ATP = D-alanyl-D-threonine + ADP + phosphate
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-threonine amide + H2O = D-Thr + NH3
show the reaction diagram
-
L-threonine = D-threonine
show the reaction diagram
-
L-threonine = D-threonine
show the reaction diagram
-
L-Thr = D-Thr
show the reaction diagram
-

Activator in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
1 mM, relative activity 120%
-
115% activity at 50 mM with D-methionine as substrate
-

Inhibitor in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
slight
-
94% residual activity at 5 mM with L-methionine as substrate
-

3D Structure of Enzyme-Ligand-Complex (PDB) (4 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (16 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.68
-
pH 8.7, 37°C
0.2
-
pH 8.0, temperature not specified in the publication

KM Value (30 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.06
-
-
2.47
-
pH 8.7, 37°C
10.9
-
pH 8.0, temperature not specified in the publication
9.8
-
-

References & Links

Links to other databases for D-threonine

ChEBI
PubChem
-
PubChem