Ligand D-Leu

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

Basic Ligand Information

Molecular Structure
Picture of D-Leu (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H13NO2
D-Leu
ROHFNLRQFUQHCH-RXMQYKEDSA-N
Synonyms:
D-leucine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + D-glutamate
show the reaction diagram
-
D-Leu = L-Leu
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (21 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-Leu + H2O + O2 = ? + NH3 + H2O2
show the reaction diagram
-
D-Leu + H2O + O2 = 4-methyl-2-oxopentanoate + H2O2
show the reaction diagram
-
D-leucine + oxidized acceptor + H2O = 4-methyl-2-oxopentanoate + NH3 + reduced acceptor
show the reaction diagram
-
D-leucine + oxidized 2,6-dichloroindophenol + H2O = 4-methyl-2-oxopentanoate + NH3 + reduced 2,6-dichloroindophenol
show the reaction diagram
-
D-leucine + 2-oxoadipate = 4-methyl-2-oxopentanoate + 2-aminoadipate
show the reaction diagram
-
S2a + D-leucine = ?
show the reaction diagram
-
D-leucine = L-leucine
show the reaction diagram
-
ATP + D-Leu = ADP + phosphate + D-Leu-D-Leu
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (33 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-oxo-4-methylvaleric acid + NH3 + NADPH + H+ = D-leucine + H2O + NADP+
show the reaction diagram
-
-
D-leucine methyl ester + H2O = D-leucine + methanol
show the reaction diagram
-
D-Leu-Gly + H2O = D-Leu + Gly
show the reaction diagram
-
-
glycyl-L-alpha-amino-epsilon-pimelyl-D-alanyl-D-leucine + H2O = glycyl-L-alpha-amino-epsilon-pimelyl-D-alanine + D-leucine
show the reaction diagram
-
-
pyroglutamyl-D-Leu + H2O = pyroglutamate + D-Leu
show the reaction diagram
-
-
benzyloxycarbonyl-Gly-Pro-D-Leu + H2O = benzyloxycarbonyl-Gly-Pro + D-Leu
show the reaction diagram
-
Gly-D-Leu + H2O = Gly + D-Leu
show the reaction diagram
-
-
N-carbamoyl-D-Leu + H2O = D-Leu + NH3 + CO2
show the reaction diagram
-
-
L-leucine = D-leucine
show the reaction diagram
-
-
L-leucine = D-leucine
show the reaction diagram
-
-

Activator in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
enhances activity at concentrations below 20 mM
-
activation of isoforms prolidase I and prolidase II
-

Inhibitor in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
weak
-
98% residual activity at 5 mM with L-methionine as substrate, 90% residual activity at 50 mM with D-methionine as substrate
-

3D Structure of Enzyme-Ligand-Complex (PDB) (3 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (10 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.7
-
mutant enzyme H56N, at pH 7.5 and 37C

KM Value (17 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
8.8
-
mutant enzyme H56N, at pH 7.5 and 37C

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
2.2
-
inhibition of deamination of D-Leu

References & Links

Links to other databases for D-Leu

ChEBI
PubChem
-
PubChem