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Ligand L-Ala-gamma-D-Glu-L-Lys Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C1 4 H2 6 N4 O6
L-Ala-gamma-D-Glu-L-Lys
IXJJWFQIGFGEEO-LPEHRKFASA-N
L-alanyl-gamma-D-glutamyl-L-lysine
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (3 results)
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L-Ala-gamma-D-Glu-L-Lys + H2O = L-Ala-D-Glu + L-Lys
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ATP + UDP-N-alpha-D-acetylmuramate + L-Ala-gamma-D-Glu-L-Lys = ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala-gamma-D-Glu-L-Lys
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ATP + L-alanyl-gamma-D-glutamyl-L-lysine + UDP-MurNAc = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine
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Product in Enzyme-catalyzed Reactions (1 result)
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1,6-anhydro-N-acetylmuramic-acid-L-Ala-gamma-D-Glu-L-Lys + H2O = 1,6-anhydro-N-acetylmuramate + L-Ala-gamma-D-Glu-L-Lys
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Enzyme Kinetic Parameters
kcat Value (Turnover Number) (3 results)
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1.2
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pH and temperature not specified in the publication
0.0042
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pH 8.4, temperature not specified in the publication, recombinant His-tagged enzyme
KM Value (2 results)
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0.29
-
pH and temperature not specified in the publication
References & Links Literature References (3)
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Biochemical characterization and physiological properties of Escherichia coli UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase
2007
Herve, M.; Boniface, A.; Gobec, S.; Bianot, D.; Mengin-Lecreulx, D.
J. Bacteriol.
189
3987-3995
Structure and function of the first full-length murein peptide ligase (Mpl) cell wall recycling protein
2011
Das, D.; Herve, M.; Feuerhelm, J.; Farr, C.; Chiu, H.; Elsliger, M.; Knuth, M.; Klock, H.; Miller, M.; Godzik, A.; Lesley, S.; Deacon, A.; Mengin-Lecreulx, D.; Wilson, I.
PLoS ONE
6
e17624
Evolution of enzymatic activities in the enolase superfamily: functional assignment of unknown proteins in Bacillus subtilis and Escherichia coli as L-Ala-D/L-Glu epimerases
2001
Schmidt, D.M.; Hubbard, B.K.; Gerlt, J.A.
Biochemistry
40
15707-15715
Links to other databases for L-Ala-gamma-D-Glu-L-Lys
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