Ligand hydroxyurea

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Basic Ligand Information

Molecular Structure
Picture of hydroxyurea (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
CH4N2O2
hydroxyurea
VSNHCAURESNICA-UHFFFAOYSA-N
Synonyms:
1-hydroxyurea, N-hydroxyurea, N-hydroxy urea

Show all pahtways known for Show all pathways known for hydroxyurea

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
O-acetyl-L-serine + hydroxyurea = O-ureido-L-serine + acetate
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
Nomega-hydroxy-L-arginine + H2O = L-ornithine + hydroxyurea
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
O3-acetyl-L-serine + N-hydroxyurea = O-ureidoserine + acetate
show the reaction diagram
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O3-acetyl-L-serine + N-hydroxyurea = ureidoserine + acetate
show the reaction diagram
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O-acetyl-L-serine + hydroxyurea = O-ureido-L-serine + acetate
show the reaction diagram
-
hydroxyurea = HCO3- + NH4+ + NH2OH
show the reaction diagram
-
1-hydroxyurea + H2O = ?
show the reaction diagram
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O-Acetyl-L-serine + N-hydroxyurea = ?
show the reaction diagram
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ATP + hydroxyurea + HCO3- = ?
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
Nomega-hydroxy-L-arginine + H2O = L-ornithine + hydroxyurea
show the reaction diagram
-
-

Inhibitor in Enzyme-catalyzed Reactions (36 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
cell lines CAL 27, CAL 33, CAL 51, ORL 1, PANC 3
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cell lines CAL 27, CAL 33, CAL 51, ORL 1, PANC 3
-
supresses thymidilate synthase in growing algae, but no effect on purified enzyme
-
inhibitor of DNA synthesis
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Ki of strain AI3 is 1.4 mM, Ki of strain AIU1N is 10.8 mM and Ki of strain OUCH4 is 337 mM, regaines full activity within 24 h at 37°C in 0.05 M Tris buffer at pH 7.2; reversible inhibition, pH 7.2 and 37°C
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IC50 against Escherichia coli peptide deformylase: 0.0022 mM
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3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (3 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (3 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

Ki Value (7 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.69
-
-
1.04
-
competitive

IC50 Value (3 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
1.7
-
-
0.1
-
IC50: 0.1 mM
0.0022
-
IC50 against Escherichia coli peptide deformylase: 0.0022 mM

References & Links

Links to other databases for hydroxyurea

ChEBI
PubChem
ChEBI
PubChem