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Ligand adenosylcobyrinic acid a,c-diamide

Basic Ligand Information

Molecular Structure

Show all BRENDA pathways known for adenosylcobyrinic acid a,c-diamide

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Natural Substrate (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

6.3.5.10

adenosylcobyrinic acid a,c-diamide + ATP + L-glutamine + H2O = adenosylcobyric acid + ADP + phosphate + L-glutamate

653832

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6.3.5.10

ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O = ADP + phosphate + adenosylcobyric acid + L-glutamate

644281, 651618, 644278, 636869, 655868, 653832

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6.3.5.10

2 entries

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

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Show Natural Product (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.5.1.17

ATP + cob(I)yrinic acid a,c-diamide = triphosphate + adenosylcob(III)yrinic acid a,c-diamide

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Substrate in Enzyme-catalyzed Reactions (5 results)

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Show Substrate (5 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

6.3.5.10

adenosylcobyrinic acid a,c-diamide + ATP + L-glutamine + H2O = adenosylcobyric acid + ADP + phosphate + L-glutamate

653832, 651618

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6.3.5.10

ATP + adenosylcobyrinic acid a,c-diamide + ammonia + H2O = ADP + phosphate + adenosylcobyric acid + ?

651618

-

6.3.5.10

ATP + adenosylcobyrinic acid a,c-diamide + L-glutamine + H2O = ADP + phosphate + adenosylcobyric acid + L-glutamate

644281, 655868, 651618, 644278, 636869, 653832

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6.3.5.10

ATP + adenosylcobyrinic acid diamide + L-glutamine + H2O = ADP + phosphate + adenosylcobyric acid + L-glutamate

674206

-

6.3.5.10

4 entries

6.3.5.9

ATP + adenosyl-cobyrinic acid a,c-diamide + L-glutamine + H2O = ADP + phosphate + ?

651618

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Product in Enzyme-catalyzed Reactions (1 result)

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Show Product (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.5.1.17

ATP + cob(I)yrinic acid a,c-diamide = triphosphate + adenosylcob(III)yrinic acid a,c-diamide

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Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (1 result)

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Show Turnover Number (1 entry)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

6.3.5.10

3.6

-

30°C, pH 7.5

674206

K_M Value (3 results)

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Show KM Value (3 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

6.3.5.10

0.00104

-

pH 7.5

651618

6.3.5.10

0.0027

-

30°C, pH 7.5

674206

6.3.5.10

2 entries

6.3.5.9

0.00104

-

pH 7.5, 20°C

651618

References & Links

Literature References (7)

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Show Reference (7 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

636869

1655697

Nucleotide sequence and genetic analysis of a 13.1-kilobase-pair Pseudomonas denitrificans DNA fragment containing five cob genes and identification of structural genes encoding Cob(I)alamin adenosyltransferase, cobyric acid synthase, and bifunctional cobinamide kinase-cobinamide phosphate guanylyltransferase

1991

Crouzet, J.; Levy-Schil, S.; Cameron, B.; Cauchois, L.; Rigault, S.; Rouyez, M.C.; Blanche, F.; Debussche, L.; Thibaut, D.

J. Bacteriol.

173

6074-6087

644278

12195810

The biosynthesis of adenosylcobalamin (vitamin B12)

2002

Warren, M.J.; Raux, E.; Schubert, H.L.; Escalante-Semerena, J.C.

Nat. Prod. Rep.

19

390-412

644281

1429467

Purification and characterization of cob(II)yrinic acid a,c-diamide reductase from Pseudomonas denitrificans

1992

Blanche F.; Maton, L.; Debussche, L.; Thibaut, D.

J. Bacteriol.

174

7452-7454

651618

1917839

Biosynthesis of vitamin B12: stepwise amidation of carboxyl groups b, d, e, and g of cobyrinic acid a,c-diamide is catalyzed by one enzyme in Pseudomonas denitrificans

1991

Blanche, F.; Couder, M.; Debussche, L.; Thibaut, D.; Cameron, B.; Cruzet, J.

J. Bacteriol.

173

6046-6051

653832

10966576

The synthetase domains of cobalamin biosynthesis amidotransferases cobB and cobQ belong to a new family of ATP-dependent amidoligases, related to dethiobiotin synthetase

2000

Galperin, M.Y.; Grishin, N.V.

Proteins

41

238-247

655868

14645280

A new pathway for salvaging the coenzyme B12 precursor cobinamide in archaea requires cobinamide-phosphate synthase (CbiB) enzyme activity

2003

Woodson, J.D.; Zayas, C.L.; Escalante-Semerena, J.C.

J. Bacteriol.

185

7193-7201

674206

17212407

The multiple amidation reactions catalyzed by cobyric acid synthetase from Salmonella typhimurium are sequential and dissociative

2007

Williams, L.; Fresquet, V.; Santander, P.J.; Raushel, F.M.

J. Am. Chem. Soc.

129

294-295

Links to other databases for adenosylcobyrinic acid a,c-diamide

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Show Links (1 entry)

ChEBI

PubChem

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