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Ligand 2-mercaptopurine Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C5 H4 N4 S
2-mercaptopurine
HDBQZGJWHMCXIL-UHFFFAOYSA-N
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (2 results)
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2-mercaptopurine + H2O + O2 = 8-hydroxy-2-mercaptopurine + H2O2
-
thymidine + 2-mercaptopurine = more
-
Inhibitor in Enzyme-catalyzed Reactions (1 result)
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Enzyme Kinetic Parameters
kcat Value (Turnover Number) (1 result)
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KM Value (1 result)
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References & Links Literature References (3)
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Xanthine phosphoribosyltransferase from Streptococcus faecalis. Properties and specificity
1974
Miller, R.L.; Adamczyk, D.L.; Fyfe, J.A.; Elion, G.B.
Arch. Biochem. Biophys.
165
349-358
trans-N-Deoxyribosylase: substrate specificity studies. Purine bases as acceptors
1975
Holguin, J.; Cardinaud, R.
Eur. J. Biochem.
54
515-520
Nature and position of functional group on thiopurine substrates influence activity of xanthine oxidase - enzymatic reaction pathways of 6-mercaptopurine and 2-mercaptopurine are different
2007
Tamta, H.; Kalra, S.; Thilagavathi, R.; Chakraborti, A.K.; Mukhopadhyay, A.K.
Biochemistry (Moscow)
72
170-177
Links to other databases for 2-mercaptopurine