Ligand Ferredoxin

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Basic Ligand Information

Molecular Formula
BRENDA Name
InChIKey
Ferredoxin

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
stearoyl-[acyl-carrier protein] + ferredoxin + O2 = oleoyl-[acyl-carrier protein] + oxidized ferredoxin + H2O
show the reaction diagram
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ferredoxin + NADH = reduced ferredoxin + NAD+ + H+
show the reaction diagram
-
formylmethanofuran + H2O + ferredoxin = CO2 + methanofuran + reduced ferredoxin
show the reaction diagram
-
CO + ferredoxin = ?
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
4-methoxybenzoate + reduced ferredoxin + O2 = 4-hydroxybenzoate + formaldehyde + ferredoxin + H2O
show the reaction diagram
-
-
7,8-dihydromethanopterin + reduced ferredoxin = 5,6,7,8-tetrahydromethanopterin + ferredoxin
show the reaction diagram
-
-
coenzyme B-coenzyme M disulfide + reduced ferredoxin = coenzyme B + coenzyme M + ferredoxin
show the reaction diagram
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-

Substrate in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
H2 + ferredoxin = H+ + reduced ferredoxin
show the reaction diagram
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H2 + ferredoxin + oxidized metronidazole = H+ + ferredoxin + reduced metronidazole
show the reaction diagram
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heme + ferredoxin + O2 = biliverdin IXalpha + Fe2+ + CO + A + H2O
show the reaction diagram
-
18-fluoro-10-thiaoctadecanoyl-[acyl-carrier protein] + O2 + ferredoxin = ?
show the reaction diagram
-
stearoyl-[acyl-carrier protein] + ferredoxin + O2 = oleoyl-[acyl-carrier protein] + oxidized ferredoxin + H2O
show the reaction diagram
-
xanthine + ferredoxin + H2O = urate + reduced ferredoxin
show the reaction diagram
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ferredoxin + NADH = reduced ferredoxin + NAD+ + H+
show the reaction diagram
-
oxalate + ferredoxin = CO2 + reduced ferredoxin
show the reaction diagram
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formylmethanofuran + H2O + ferredoxin = CO2 + methanofuran + reduced ferredoxin
show the reaction diagram
-
crotonyl-CoA + NADH + ferredoxin = butyryl-CoA + ?
show the reaction diagram
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coenzyme B-coenzyme M disulfide + ferredoxin + 2 H2 = coenzyme B + coenzyme M + reduced ferredoxin2- + 2 H+
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
H2 + ferredoxin + oxidized metronidazole = H+ + ferredoxin + reduced metronidazole
show the reaction diagram
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25-hydroxycholesterol + O2 + reduced ferredoxin = pregnenolone + H2O + ferredoxin + 4-hydroxy-4-methylpentanal
show the reaction diagram
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4-methoxybenzoate + reduced ferredoxin + O2 = 4-hydroxybenzoate + formaldehyde + ferredoxin + H2O
show the reaction diagram
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-
benzoyl-CoA + reduced ferredoxin + ATP = cyclohexa-1,5-diene-1-carbonyl-CoA + ferredoxin + ADP + phosphate
show the reaction diagram
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5,10-methylenetetrahydrofolate + reduced ferredoxin = 5-methyltetrahydrofolate + ferredoxin
show the reaction diagram
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7,8-dihydromethanopterin + reduced ferredoxin = 5,6,7,8-tetrahydromethanopterin + ferredoxin
show the reaction diagram
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Enzyme Cofactor/Cosubstrate (136 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
the hydrogenase requires the presence of both electron carriers, NADH and reduced ferredoxin, synergistically for catalysis of H2 production
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required for activity
-
several MMOR ferredoxin analogues, intermolecular electron transfer from ferredoxin analogues to hydroxylase protein MMOH, redox potential determinations, overview
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required
-
Rieske-type alkane monooxygenase with Rieske-type [2Fe-2S]2 center
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isozyme in mitochondria
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requirement of ferredoxin and indirectly of ferredoxin reductase in hydroxylation of heme O
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ferredoxin contains eight atoms of iron and eight acid-labile sulfur groups per molecule. The molecular mass is 6400 Da, the isoelelctric point 3.4. Ferredoxin is stable for at least 1 h at 70°C
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Km-value 0.06 mM
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butyryl-CoA dehydrogenase from C. difficile belongs to the subfamily of bifurcating enzymes capable of coupling the exergonic reduction of crotonyl-CoA by NAD Hwith the endergonic reduction of ferredoxin by NADH
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reduced or oxidized, as electron carrier
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ferredoxin may serve as an electron donor
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[4Fe-4S]-ferredoxin cofactor
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can partly substitute for flavodoxin
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Fd-II, which harbors two [4Fe-4S] clusters and is an electron acceptor for CODH, serves as a redox activator of ACS. Catalytic one-electron redox-active species in the CO/acetyl-CoA exchange reaction. Incubation of ACS with Fd-II and CO leads to the formation of the NiFeC species. FdII is purified from Moorella thermoacetica, overview
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required
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identification of Synechocystis sp. PC 6803 ssl0020 ferredoxin, PetF, UniProt ID P27320, as an efficient ADO reductant, overview
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alternative electron donor besides flavodoxin is a two [4Fe-4S]1+/2+-cluster-containing ferredoxin, with redox potentials of –405 mV and –340mV. The flavodoxin is the dominant electron donor protein under iron-limiting conditions. The concentration of ferredoxin increases stepwise from about 0.2 micromol/g at 7–13 microM Fe to 1.1 micromol/g at 17–45 microM Fe
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Activator in Enzyme-catalyzed Reactions (15 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
indispensable for catalytic activity
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in absence loss of desaturase activity
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26fold increase of cytochrome c reduction, 2fold increase of oxygen reduction
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enzyme is present throughout the life cycle of the plants, inactive enzyme is converted during greening to an active state by light either via enzyme effectors or via the ferredoxin-thioredoxin system
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dependent on
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activates
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enzyme activity is dependent on the presence of flavodoxin, ferredoxin, or flavodoxin-NADP+ reductase
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Inhibitor in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (2 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
20.2
-
cosubstrate xanthine
37
-
pH 7.5, temperature not specified in the publication

KM Value (8 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.008
-
-
0.048
-
-
0.002
-
pH 7.5, temperature not specified in the publication

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.05
0.1
pH 8.0, 25°C

References & Links

Links to other databases for Ferredoxin