Ligand thio-NADPH

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Basic Ligand Information

Molecular Structure
Picture of thio-NADPH (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C21H30N7O16P3S
thio-NADPH
UOCQAQQJWFGQFW-NNYOXOHSSA-N
Synonyms:
beta-thio-NADPH, thio-NAD(P)H, thionicotinamide-NADPH

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-oxopantoate + thio-NADPH = (R)-pantoate + thio-NADP+
show the reaction diagram
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2,3-dihydrodipicolinate + thio-NADPH + H+ = 2,3,4,5-tetrahydrodipicolinate + thio-NADP+ + H2O
show the reaction diagram
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L-glutamine + 2-oxoglutarate + thio-NADPH + H+ = L-glutamate + thio-NADP+
show the reaction diagram
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des-myo-inositol mycothione + thio-NADPH = ?
show the reaction diagram
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thio-NADPH + NAD+ + H+[side 1] = thio-NADP+ + NADH + H+[side 2]
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-mannitol + thio-NADP+ = D-fructose + thio-NADPH
show the reaction diagram
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D-glucose 6-phosphate + thionicotinamide-NADP+ = 6-phospho-D-glucono-1,5-lactone + thionicotinamide-NADPH + H+
show the reaction diagram
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D-glucose 6-phosphate + thio-NAD(P)+ = D-glucono-1,5-lactone 6-phosphate + thio-NAD(P)H
show the reaction diagram
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thio-NAD+ + NAD(P)H = NAD+ + thio-NAD(P)H
show the reaction diagram
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Enzyme Cofactor/Cosubstrate (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (2 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (6 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.018
-
pH 7.5, 25°C, recombinant enzyme
0.0021
-
-
0.01
-
in the presence of 2.5 mM 2-oxo-glutarate and 5 mM L-glutamine, the apparent maximal velocity is 54% that obtained in the presence of NADPH
0.001
-
des-myo-inositol mycothione as second substrate

References & Links

Links to other databases for thio-NADPH

ChEBI
PubChem
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PubChem