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Ligand lysophosphatidic acid

Basic Ligand Information

Molecular Structure

Pathway Source

Pathways

BRENDA

CDP-diacylglycerol biosynthesis

KEGG

Biosynthesis of secondary metabolites, Fat digestion and absorption, Gap junction, Glycerolipid metabolism, Glycerophospholipid metabolism, Neuroactive ligand-receptor interaction, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Regulation of actin cytoskeleton, Vitamin digestion and absorption more

MetaCyc

anandamide biosynthesis I, CDP-diacylglycerol biosynthesis I, CDP-diacylglycerol biosynthesis II, CDP-diacylglycerol biosynthesis III, diacylglycerol and triacylglycerol biosynthesis, monoacylglycerol metabolism (yeast), palmitoleate biosynthesis III (cyanobacteria), phosphatidate biosynthesis (yeast), phospholipid remodeling (phosphatidate, yeast) more

Show all BRENDA pathways known for lysophosphatidic acid

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (9 results)

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Show Natural Substrate (9 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.51

acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate

671597, 735703, 756599, 687752, 687813, 737221, 487198, 685339, 736479, 673280, 705005, 734968, 757793, 746468, 755967, 705011, 706333, 706324, 487179, 487180, 486338, 486486, 486341, 487184, 660235, 657783, 674530, 675752, 675264, 688005, 687624, 735599, 755824

-

2.3.1.51

acyl-[acyl-carrier protein] + 1-acyl-sn-glycerol 3-phosphate = ACP + 1,2-diacyl-sn-glycerol 3-phosphate

486339

-

2.3.1.51

acyl-[acyl-carrier protein] + 1-acyl-sn-glycerol 3-phosphate = acyl-carrier protein + 1,2-diacyl-sn-glycerol 3-phosphate

756093

-

2.3.1.51

arachidonoyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1-acyl-2-arachidonoyl-sn-glycerol 3-phosphate

705005

-

2.3.1.51

palmitoyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1-acyl-2-palmitoyl-sn-glycerol 3-phosphate

755759

-

3.1.3.106

lysophosphatidate + H2O = monoacylglycerol + phosphate

702463

-

3.1.3.106

lysophosphatidic acid + H2O = monoacylglycerol + phosphate

663947

-

2.3.1.51

5 entries

3.1.3.106

2 entries

3.1.3.2

lysophosphatidic acid + H2O = monoacylglycerol + phosphate

664939

-

3.1.3.4

lysophosphatidic acid + H2O = monoacylglycerol + phosphate

665805, 663975, 663994, 663967, 665748, 749773

-

In Vivo Product in Enzyme-catalyzed Reactions (14 results)

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Show Natural Product (14 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.101

acyldihydroxyacetone phosphate + NADPH = 1-acyl-sn-glycerol 3-phosphate + NADP+

285689, 285691, 285693, 285696, 285690, 285684, 285688, 285685, 285694, 285695

-

2.3.1.15

acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate

0, 486358, 486343, 486337, 486348, 486372

-

2.3.1.15

acyl-[acyl-carrier protein] + sn-glycerol 3-phosphate = acyl-carrier protein + 1-acyl-sn-glycerol 3-phosphate

486381

-

2.3.1.15

acyl-CoA + sn-glycerol 3-phosphate = CoA + lysophosphatidic acid

0

-

2.7.1.94

ATP + acylglycerol = ADP + acyl-sn-glycerol 3-phosphate

0

-

2.7.1.94

ATP + acylglycerol = ADP + lysophosphatidic acid

0

-

2.7.1.94

ATP + monoacylglycerol = ADP + lysophosphatidic acid

0

-

2.3.1.15

3 entries

2.7.1.94

3 entries

3.1.4.38

lysophosphatidylcholine + H2O = choline + 2-lysophosphatidate

0

-

3.1.4.39

lysophosphatidyl choline + H2O = lysophosphatidic acid + choline

0

-

3.1.4.39

lysophosphatidylcholine + H2O = lysophosphatidic acid + choline

0

-

3.1.4.41

2-lysophosphatidylcholine + H2O = 2-lysophosphatidate + choline

0

-

3.1.4.41

2-lysophosphatidylcholine + H2O = choline + 2-lysophosphatidate

0

-

3.1.4.41

2-lysophosphatidylcholine + H2O = lysophosphatidic acid + choline

0

-

3.1.4.41

lysophosphatidylcholine + H2O = lysophosphatidic acid + choline

0

-

3.1.4.39

2 entries

3.1.4.41

4 entries

Substrate in Enzyme-catalyzed Reactions (40 results)

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Show Substrate (40 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.149

1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine + acyllyso-sn-glycero-3-phosphate = ?

16279

-

2.3.1.51

acyl-ACP + 1-acyl-sn-glycerol 3-phosphate = ACP + 1,2-diacyl-sn-glycerol 3-phosphate

486341, 486339

-

2.3.1.51

acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate

671597, 675264, 735703, 756599, 487192, 687752, 486635, 687813, 486345, 486339, 737221, 486335, 487198, 487204, 685339, 736479, 673280, 674530, 705005, 734968, 757793, 746468, 755824, 755967, 486373, 487180, 486338, 486634, 487188, 487193, 487179, 486375, 486341, 487184, 487194, 486374, 486630, 487210, 487191, 486486, 705011, 706333, 706324, 660235, 657783, 675752, 688005, 687624, 735599

-

2.3.1.51

acyl-[acyl-carrier protein] + 1-acyl-sn-glycerol 3-phosphate = ACP + 1,2-diacyl-sn-glycerol 3-phosphate

486339

-

2.3.1.51

acyl-[acyl-carrier protein] + 1-acyl-sn-glycerol 3-phosphate = acyl-carrier protein + 1,2-diacyl-sn-glycerol 3-phosphate

756093

-

2.3.1.51

arachidonoyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1-acyl-2-arachidonoyl-sn-glycerol 3-phosphate

487202, 487210, 486635, 487194, 487204, 705005, 486486, 486634, 486345

-

2.3.1.51

arachidoyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1-acyl-2-arachidoyl-sn-glycerol 3-phosphate

487204

-

2.3.1.51

behenoyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1-acyl-2-behenoyl-sn-glycerol 3-phosphate

487205

-

2.3.1.51

capryl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1-acyl-2-capryl-sn-glycerol 3-phosphate

487203

-

2.3.1.51

cis-11-eicosenoyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1-acyl-2-cis-11 eicosenoyl-sn-glycerol 3-phosphate

487203

-

2.3.1.51

eicosatetraenoyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1-acyl-2-eicosatetraenoyl-sn-glycerol 3-phosphate

487191

-

2.3.1.51

erucoyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1-acyl-2-erucoyl-sn-glycerol 3-phosphate

487203, 486345

-

2.3.1.51

gondoyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1-acyl-2-gondoyl-sn-glycerol 3-phosphate

487184

-

2.3.1.51

lauroyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1-acyl-2-lauroyl-sn-glycerol 3-phosphate

487203, 486635, 487204, 487206, 486374, 486486, 486634

-

2.3.1.51

lignoceroyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1-acyl-2-lignoceroyl-sn-glycerol 3-phosphate

487205, 487204

-

2.3.1.51

linolenoyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1-acyl-2-linolenoyl-sn-glycerol 3-phosphate

487205, 487191, 487204

-

2.3.1.51

linoleoyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1-acyl-2-linoleoyl-sn-glycerol 3-phosphate

487210, 487205, 486486, 486635, 487191, 486345, 486341, 487204, 486634

-

2.3.1.51

myristoyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1-acyl-2-myristoyl-sn-glycerol 3-phosphate

487210, 487204, 486374, 486486, 486634

-

2.3.1.51

myristoyl-[acyl-carrier protein] + 1-acyl-sn-glycerol 3-phosphate = acyl-carrier protein + 1-acyl-2-myristoyl-sn-glycerol 3-phosphate

756093

-

2.3.1.51

oleoyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1-acyl-2-oleoyl-sn-glycerol 3-phosphate

487202, 487210, 487180, 487203, 487205, 486486, 486635, 487191, 487194, 487211, 487192, 486375, 487188, 486341, 486335, 487199, 487204, 486373, 487184, 486634, 486374, 706333

-

2.3.1.51

palmitoleoyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1-acyl-2-palmitoleoyl-sn-glycerol 3-phosphate

486486, 487200, 486634, 487204

-

2.3.1.51

palmitoyl-ACP + 1-acyl-sn-glycerol 3-phosphate = ACP + 1-acyl-2-palmitoyl-sn-glycerol 3-phosphate

487184, 487207

-

2.3.1.51

palmitoyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1-acyl-2-palmitoyl-sn-glycerol 3-phosphate

487202, 487210, 486373, 487179, 487180, 487203, 487205, 687752, 486338, 486486, 486630, 486635, 487191, 487211, 486375, 486345, 487188, 487184, 486335, 487204, 757793, 755759, 487193, 486374, 486634, 486341, 685339, 687813

-

2.3.1.51

palmitoyl-[acyl carrier protein] + 1-acyl-sn-glycerol 3-phosphate = acyl carrier protein + 1-acyl-2-palmitoyl-sn-glycerol 3-phosphate

757793

-

2.3.1.51

stearoyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1-acyl-2-stearoyl-sn-glycerol 3-phosphate

487210, 487205, 487204, 486486, 486634, 486345

-

2.3.1.51

oleoyl-CoA + lysophosphatidic acid = CoA + 1,2-diacyl-sn-glycerol 3-phosphate

675752

-

2.3.1.51

25 entries

2.3.1.67

acetyl-CoA + 1-acyl-sn-glycero-3-phosphate = CoA + 2-acetyl-1-acyl-sn-glycero-3-phosphate

487384

-

3.1.1.32

L-alpha-phosphatidylglycerol + H2O = ?

729743

-

3.1.1.5

1-acyl-sn-glycero-3-phosphate + H2O = fatty acid + glyceryl phosphate

94384

-

3.1.3.106

lysophosphatidate + H2O = monoacylglycerol + phosphate

714378, 702463

-

3.1.3.106

lysophosphatidic acid + H2O = monoacylglycerol + phosphate

663947

-

3.1.3.106

2 entries

3.1.3.2

lysophosphatidic acid + H2O = monoacylglycerol + phosphate

664939

-

3.1.3.4

1-acyl-sn-glycerol 3-phosphate + H2O = 1-acyl-sn-glycerol + phosphate

134866, 134879

-

3.1.3.4

lyso-phosphatidate + H2O = monoacylglycerol + phosphate

751124

-

3.1.3.4

lyso-phosphatidic acid + H2O = monoacylglycerol + phosphate

680744, 681760, 680723, 679860, 681013

-

3.1.3.4

lysophosphatidate + H2O = ?

134897, 134885, 134886, 134884

-

3.1.3.4

lysophosphatidate + H2O = monoacylglycerol + phosphate

650322, 751935

-

3.1.3.4

lysophosphatidic acid + H2O = ?

651209, 678372, 679998

-

3.1.3.4

lysophosphatidic acid + H2O = ? + phosphate

694357, 691384

-

3.1.3.4

lysophosphatidic acid + H2O = monoacylglycerol + phosphate

665805, 649679, 663975, 663994, 666926, 710376, 651767, 663967, 665748, 708068, 749773

-

3.1.3.4

8 entries

Product in Enzyme-catalyzed Reactions (36 results)

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Show Product (36 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.101

acyldihydroxyacetone phosphate + NADPH = 1-acyl-sn-glycerol 3-phosphate + NADP+

285684, 285688, 285690, 285692, 285696, 285689, 285685, 285686, 285691, 285695, 285687, 285693, 285694

-

2.3.1.15

acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate

486347, 0, 486358, 486342, 486337, 486344, 486392, 486340, 486372, 486380, 486391, 486339, 486381, 486374, 486345, 486357, 486343, 486348

-

2.3.1.15

acyl-[acyl-carrier protein] + sn-glycerol 3-phosphate = acyl-carrier protein + 1-acyl-sn-glycerol 3-phosphate

486357, 486358, 486368, 486372, 486395, 486339, 486381

-

2.3.1.15

acyl-[acyl-carrier protein] + sn-glycerol 3-phosphate = [acyl-carrier protein] + 1-acyl-sn-glycerol 3-phosphate

0

-

2.3.1.15

acyl-CoA + glycerol-3-phosphate = CoA + lysophosphatidic acid

0

-

2.3.1.15

acyl-CoA + sn-glycerol 3-phosphate = CoA + lysophosphatidic acid

0

-

2.3.1.15

acyl-[acyl-carrier protein] + glycerol-3-phosphate = [acyl-carrier protein] + lysophosphatidic acid

0

-

2.3.1.15

fatty acyl-CoA + glycerol-3-phosphate = CoA + lysophosphatidic acid

0

-

2.7.1.94

ATP + acylglycerol = ADP + acyl-sn-glycerol 3-phosphate

0

-

2.7.1.94

ATP + acylglycerol = ADP + lysophosphatidic acid

0

-

2.7.1.94

ATP + monoacylglycerol = ADP + lysophosphatidic acid

0

-

2.3.1.15

7 entries

2.7.1.94

3 entries

3.1.1.111

phosphatidic acid + H2O = lysophosphatidic acid + a fatty acid

0

-

3.1.1.32

phosphatidic acid + H2O = lysophosphatidic acid + a carboxylate

650395

-

3.1.1.4

1,2-diacyl-sn-glycero-3-phosphate + H2O = 1-acyl-sn-glycero-3-phosphate + a carboxylate

0

-

3.1.1.4

1,2-diacyl-sn-glycero-3-phosphatide + H2O = 1-acyl-sn-glycero-3-phosphatide + fatty acid

133925, 133907

-

3.1.1.4

phosphatidic acid + H2O = 1-acylglycerophosphate + fatty acid

133911, 133925, 133931

-

3.1.1.4

3 entries

3.1.1.52

1-acyl-2-oleoyl-sn-glycerol 3-phosphate + H2O = 1-acylglycerol 3-phosphate + oleic acid

80967

-

3.1.4.38

lysophosphatidylcholine + H2O = choline + 2-lysophosphatidate

0

-

3.1.4.39

lyso-phosphatidylcholine + H2O = lyso-phosphatidic acid + choline

0

-

3.1.4.39

lysophosphatidylcholine + H2O = lysophosphatic acid + choline

0

-

3.1.4.39

lysophosphatidyl choline + H2O = lysophosphatidic acid + choline

0

-

3.1.4.39

lysophosphatidyl ethanolamine + H2O = lysophosphatidic acid + ethanolamine

0

-

3.1.4.39

lysophosphatidylcholine + H2O = lysophosphatidic acid + choline

0

-

3.1.4.39

N-arachidonoyl-lysophosphatidylethanolamine + H2O = lysophosphatidic acid + N-arachidonoyl-ethanolamine

0

-

3.1.4.39

N-arachidonoyllysophosphatidylethanolamine + H2O = lysophosphatidic acid + N-arachidonoylethanolamine

0

-

3.1.4.39

N-oleoyl-lysophosphatidylethanolamine + H2O = lysophosphatidic acid + N-oleoyl-ethanolamine

0

-

3.1.4.39

N-oleoyllysophosphatidylethanolamine + H2O = lysophosphatidic acid + N-oleoylethanolamine

0

-

3.1.4.39

N-palmitoyl-lysophosphatidylethanolamine + H2O = lysophosphatidic acid + N-palmitoyl-ethanolamine

0

-

3.1.4.39

N-palmitoyllysophosphatidylethanolamine + H2O = lysophosphatidic acid + N-palmitoylethanolamine

0

-

3.1.4.4

lysophosphatidylcholine + H2O = choline + lysophosphatidate

650848

-

3.1.4.4

lysophosphatidylcholine + H2O = choline + lysophosphatidic acid

0

-

3.1.4.41

2-lysophosphatidylcholine + H2O = 2-lysophosphatidate + choline

135481, 0

-

3.1.4.41

2-lysophosphatidylcholine + H2O = choline + 2-lysophosphatidate

0

-

3.1.4.41

2-lysophosphatidylcholine + H2O = lysophosphatidic acid + choline

0

-

3.1.4.41

lysophosphatidylcholine + H2O = lysophosphatidic acid + choline

0, 135478, 652516

-

3.1.4.39

11 entries

3.1.4.4

2 entries

3.1.4.41

4 entries

3.1.4.46

2-lysophosphatidylcholine + H2O = choline + 2-lysophosphatidate

0

-

Activator in Enzyme-catalyzed Reactions (14 results)

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Show Activating Compound (14 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.B41

highly activating

757236

-

2.7.1.154

activates PI3KC2beta in SKOV3 cells

761670

-

2.7.1.68

-

661660

-

2.7.1.68

mechanism overview

661660

-

2.7.1.68

2 entries

2.7.10.2

activates fyn

673700

-

2.7.11.1

activates isozyme PKNalpha

662053

-

3.1.1.118

weak activation

760614

-

3.1.4.11

slight activation, less effective in stimulating PLC-beta1 activity than phosphatidic acid

649997

-

3.1.4.4

-

135449

-

3.4.21.109

weaker activator than sphingosine 1-phosphate

652223

-

3.6.5.2

activation of Rho, assembly of contractile actin-myosin filaments and focal adhesion complexes

644119

-

3.6.5.2

induces rapid and strong RhoA activation

698384

-

3.6.5.2

stimulates Rac1 as cardiovascular stimulus

734348

-

3.6.5.2

3 entries

7.2.2.3

stimulates the enzyme to 120% at 0.01 nM. Protein kinase C mediates the modulation of Na+-ATPase activity by lysophosphatidic acid

711296

-

Inhibitor in Enzyme-catalyzed Reactions (32 results)

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Show Inhibitors (32 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.15

product inhibition, all isozymes

662192

-

2.3.1.51

high concentration

486630

-

2.3.1.67

competitive inhibition for 1-alkyl-sn-glycero-3-phosphate

487384

-

2.7.1.137

-

640851

-

2.7.1.174

-

687738

-

2.7.1.40

-

723720

-

2.7.7.7

isolated from myxamoebae of Physarum polycephalum, 90% inhibition of polymerase alpha, weak inhibitor of polymerase beta

643622

-

2.7.7.7

weak inhibitor

643622

-

2.7.7.7

2 entries

3.1.1.1

-

171023

-

3.1.1.5

-

650320, 94396

-

3.1.1.5

inhibition in a dose-dependent manner

702426

-

3.1.1.5

2 entries

3.1.2.2

-

171023

-

3.1.2.20

-

171023

-

3.1.3.4

-

651209

-

3.1.3.51

-

134910

-

3.1.3.51

0.1 mM or 1 mM

134920

-

3.1.3.51

2 entries

3.1.4.12

IC50: 0.04 mM

666111

-

3.1.4.39

also fatty alcohol phosphates (structurally 1-acyl glycerol 3-phosphate analogs)

697490

-

3.1.4.39

-

698987

-

3.1.4.39

inhibits at biologically relevant concentrations

696397

-

3.1.4.39

-

705057

-

3.1.4.39

0.001 mM, complexed to albumin, competitive and noncompetitive components

665628

-

3.1.4.39

efficacious inhibitor of ATX activity

702693

-

3.1.4.39

product inhibition of autotaxin/lysoPLD by lysophosphatidic acid, which is a potent mixed (both competitive and noncompetitive) inhibitor of the hydrolysis of lysoPC by autotaxin/lysoPLD in vitro. Possibility that lysophosphatidic acid regulates its own biosynthesis through feedback inhibition of autotaxin/lysoPLD

681769

-

3.1.4.39

reported as an inhibitor of its own production; reported as an inhibitor of its own production

680925

-

3.1.4.39

8 entries

3.1.4.50

-

646476

-

3.3.2.2

competitive

715622

-

3.5.1.23

isoenzyme I only

171993

-

3.6.1.75

-

680603

-

4.1.1.31

addition of 0.05 mM phosphatidic acid decreases PEPC activity to approximately 45% of the control activity

706331

-

4.6.1.2

preincubations for 30 min before assessments of atrial natriuretic peptide-induced cGMP generation reveals inhibitory effects, exerted in a dose-dependent manner, elicits GC-A desensitization, protein kinase A does not block lysophosphatidic acid-induced heterologous desensitization. MEK inhibitor PD 98059 does not protect against the lysophosphatidic acid-mediated decrease in GC-A hormone sensitivity

679514

-

7.4.2.1

ATP-binding subunit HisP with a carboxy-terminal extension of 8 amino acids

246888

-

Enzyme Kinetic Parameters

K_M Value (12 results)

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Show KM Value (12 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.3.1.51

0.0053

-

I208A, mutant of human AGPAT1

685339

2.3.1.51

0.0054

-

P207L, mutant of human AGPAT1

685339

2.3.1.51

0.0064

-

human AGPAT1

685339

2.3.1.51

0.024

-

T180S, mutant of human AGPAT1

685339

2.3.1.51

0.0342

-

R149K, mutant of human AGPAT1

685339

2.3.1.51

0.125

-

in the incorporation of palmitate and linoleate

487191

2.3.1.51

6 entries

2.3.1.67

0.011

-

-

487384

3.1.3.4

0.046

-

pH 6.5, 37°C

751935

3.1.3.4

0.083

-

pH 6.5, 37°C

751935

3.1.3.4

0.179

-

pH 6.5, 37°C

751935

3.1.3.4

0.295

-

pH 6.5, 37°C, recombinant isozyme DPPL1

679998

3.1.3.4

0.58

-

pH 6.5, 37°C, recombinant isozyme DPPL2

679998

3.1.3.4

5 entries

K_i Value (2 results)

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Show KI Value (2 entries)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

3.1.4.39

0.0001

-

CPF4 FRET assay (change of fluorescence intensity), inihibition involves both a reduction in vmax and an increase in km, binding affinity is 1000fold stronger than to 1-alkyl-sn-glycero-3-phosphoethanolamine and analogue substrates

697490

3.1.4.39

0.00011

-

-

665628

3.1.4.39

2 entries

IC₅₀ Value (7 results)

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Show IC50 Value (7 entries)

EC NUMBER

IC50 VALUE

IC50 VALUE MAXIMUM

COMMENTARY

LITERATURE

3.1.4.12

0.04

-

IC50: 0.04 mM

666111

3.1.4.39

0.000016

-

reported as an inhibitor of its own production, incubating human autotaxin gamma with lysophosphatidic acid

680925

3.1.4.39

0.000017

-

reported as an inhibitor of its own production, incubating human autotaxin beta with lysophosphatidic acid

680925

3.1.4.39

0.000018

-

reported as an inhibitor of its own production, incubating murine autotaxin beta with lysophosphatidic acid

680925

3.1.4.39

0.00002

-

reported as an inhibitor of its own production, incubating murine autotaxin gamma with lysophosphatidic acid

680925

3.1.4.39

0.000038

-

reported as an inhibitor of its own production, incubating human autotaxin alpha with lysophosphatidic acid

680925

3.1.4.39

0.000038

-

reported as an inhibitor of its own production, incubating murine autotaxin alpha with lysophosphatidic acid

680925

3.1.4.39

6 entries

References & Links

Literature References (176)

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Show Reference (176 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

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AUTHORS

JOURNAL

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487206

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