Ligand coenzyme M

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Basic Ligand Information

Molecular Structure
Picture of coenzyme M (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C2H6O3S2
coenzyme M
ZNEWHQLOPFWXOF-UHFFFAOYSA-N
Synonyms:
2-mercaptoethanesulfonate, 2-mercaptoethanesulfonic acid, 2-mercaptoethane sulfonic acid, CoM, CoM-SH, HS-CoM, HSCoM, mercaptoethanesulfonate, reduced coenzyme M


Show all pahtways known for Show all BRENDA pathways known for coenzyme M

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (33 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
fumarate + CoM + CoB = succinate + CoM-S-S-CoB
show the reaction diagram
-
oxidized ferredoxin [iron-sulfur] cluster + CoB + CoM = reduced ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB + H+
show the reaction diagram
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oxidized coenzyme F420 + reduced ferredoxin [iron-sulfur] cluster + CoB + CoM + H+ = reduced coenzyme F420 + oxidized ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB
show the reaction diagram
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reduced ferredoxin [iron-sulfur] cluster + CoB + CoM + H+ = H2 + oxidized ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB
show the reaction diagram
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CO2 + reduced ferredoxin [iron-sulfur] cluster + CoB + CoM + H+ = formate + oxidized ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB
show the reaction diagram
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a [methyl-Co(III) methanol-specific corrinoid protein] + coenzyme M = methyl-CoM + a [Co(I) methanol-specific corrinoid protein]
show the reaction diagram
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epoxypropane + HS-CoM = 2-hydroxypropyl-CoM
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (24 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
reduced ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB + H+ = oxidized ferredoxin [iron-sulfur] cluster + CoB + CoM
show the reaction diagram
-
-
H2 + oxidized ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB = reduced ferredoxin [iron-sulfur] cluster + CoB + CoM + H+
show the reaction diagram
-
-
5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M = 5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + H+
show the reaction diagram
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-

Substrate in Enzyme-catalyzed Reactions (53 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
fumarate + CoM + CoB = succinate + CoM-S-S-CoB
show the reaction diagram
-
insulin disulfide + 2 coenzyme M = insulin + coenzyme M disulfide
show the reaction diagram
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insulin disulfide + reduced coenzyme M = insulin dithiol + oxidized coenzyme M
show the reaction diagram
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oxidized coenzyme F420 + reduced ferredoxin [iron-sulfur] cluster + CoB + CoM + H+ = reduced coenzyme F420 + oxidized ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB
show the reaction diagram
-
CO2 + reduced ferredoxin [iron-sulfur] cluster + CoB + CoM + H+ = formate + oxidized ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB
show the reaction diagram
-
a [methyl-Co(III) methanol-specific corrinoid protein] + coenzyme M = methyl-CoM + a [Co(I) methanol-specific corrinoid protein]
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (81 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
reduced ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB + H+ = oxidized ferredoxin [iron-sulfur] cluster + CoB + CoM
show the reaction diagram
-
-
5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M = 5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + H+
show the reaction diagram
-
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2-hydroxypropyl-CoM = 1,2-epoxypropane + HS-CoM
show the reaction diagram
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-

Enzyme Cofactor/Cosubstrate (8 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
i.e. coenzyme M: function in catabolic pathway of hydrocarbon oxidation
-
coenzyme M-SH and glutathione bind to the active site
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Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (62 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
80% residual activity at 10 mM
-

3D Structure of Enzyme-Ligand-Complex (PDB) (33 results)

Enzyme Kinetic Parameters

KM Value (13 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
2.2
-
pH 6.8, 50°C
2.2
-
pH 6.8, temperature not specified in the publication
10.8
-
recombinant enzyme, pH 7.0, 37°C
0.277
-
at 37°C in 50 mM MOPS-KOH (pH 7.0)
0.034
-
-

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
2.25
-
mixed-type inhibition with respect to 2-(R)-hydroxypropyl-CoM

References & Links

Links to other databases for coenzyme M

ChEBI
PubChem
ChEBI
PubChem