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Hydrolysis of allylic phosphates by enzymes from the flavedo of Citrus sinensis
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Stereochemistry of the cyclization-rearrangement of (+)-copalyl diphosphate to (-)-abietadiene catalyzed by recombinant abietadiene synthase from Abies grandis
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Bifunctional abietadiene synthase: Free diffusive transfer of the (+)-copalyl diphosphate intermediate between two distinct active sites
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Abietadiene synthase from grand fir (Abies grandis). cDNA isolation, characterization, and bacterial expression of a bifunctional diterpene cyclase involved in resin acid biosynthesis
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Cloning of a full-length cDNA encoding ent-kaurene synthase from Gibberella fujikuroi: functional analysis of a bifunctional diterpene cyclase
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Distribution and ent-kaurene synthetase in Helianthus annuus and Marah macrocarpus
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Purification and properties of ent-kaurene synthase B from immature seeds of pumpkin
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Inhibition of ent-kaurene synthase by quaternary ammonium growth retardants
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Functional analysis of the two interacting cyclase domains in ent-kaurene synthase from the fungus Phaeosphaeria sp. L487 and a comparison with cyclases from higher plants
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The LS locus of pea encodes the gibberellin biosynthesis enzyme ent-kaurene synthase A
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Functional characterization of nine Norway spruce TPS genes and evolution of gymnosperm terpene synthases of the TPS-d subfamily
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Diterpene resin acid biosynthesis in loblolly pine (Pinus taeda): Functional characterization of abietadiene/levopimaradiene synthase (PtTPS-LAS) cDNA and subcellular targeting of PtTPS-LAS and abietadienol/abietadienal oxidase (PtAO, CYP720B1)
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Biosynthesis of cyclic diterpene hydrocarbons in rice cell suspensions: conversion of 9,10-syn-labda-8(17),13-dienyl diphosphate to 9beta-pimara-7,15-diene and stemar-13-ene
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Cloning and characterization of Ginkgo biloba levopimaradiene synthase, which catalyzes the first committed step in ginkgolide biosynthesis
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An unexpected diterpene cyclase from rice: functional identification of a stemodene synthase
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Promoter analysis of the rice stemar-13-ene synthase gene OsDTC2, which is involved in the biosynthesis of the phytoalexin oryzalexin S
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Diterpene cyclases responsible for the biosynthesis of phytoalexins, momilactones A, B, and oryzalexins A-F in rice
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Stemar-13-ene synthase, a diterpene cyclase involved in the biosynthesis of the phytoalexin oryzalexin S in rice
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A single residue switch converts abietadiene synthase into a pimaradiene specific cyclase
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Identification of syn-pimara-7,15-diene synthase reveals functional clustering of terpene synthases involved in rice phytoalexin/allelochemical biosynthesis
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Functional plasticity of paralogous diterpene synthases involved in conifer defense
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Germination of photoblastic lettuce seeds is regulated via the control of endogenous physiologically active gibberellin content, rather than of gibberellin responsiveness
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Isolation and characterization of the gibberellin biosynthetic gene cluster in Sphaceloma manihoticola
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Cloning of a gene cluster responsible for the biosynthesis of diterpene aphidicolin, a specific inhibitor of DNA polymerase alpha
2004
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Comparison of the enzymatic properties of ent-copalyl diphosphate-synthases in the biosynthesis of phytoalexins and gibberellins in rice
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Gibberellin biosynthesis in bacteria: separate ent-copalyl diphosphate and ent-kaurene synthases in Bradyrhizobium japonicum
2009
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Cloning and functional expression of cDNA encoding aphidicolan-16 beta-ol synthase: A key enzyme responsible for formation of an unusual diterpene skeleton in biosynthesis of aphidicolin
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Investigating the conservation pattern of a putative second terpene synthase divalent metal binding motif in plants
2009
Zhou, K.; Peters, R.J.
Phytochemistry
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Identification of diterpene biosynthetic gene clusters and functional analysis of labdane-related diterpene cyclases in Phomopsis amygdali
2008
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Endogenous diterpenes derived from ent-kaurene, a common gibberellin precursor, regulate protonema differentiation of the moss Physcomitrella patens
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Evident and latent plasticity across the rice diterpene synthase family with potential implications for the evolution of diterpenoid metabolism in the cereals
2011
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The primary diterpene synthase products of Picea abies levopimaradiene/abietadiene synthase (PaLAS) are epimers of a thermally unstable diterpenol
2011
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Substrate specificity of Rv3378c, an enzyme from Mycobacterium tuberculosis, and the inhibitory activity of the bicyclic diterpenoids against macrophage phagocytosis
2011
Hoshino, T.; Nakano, C.; Ootsuka, T.; Shinohara, Y.; Hara, T.
Org. Biomol. Chem.
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Combining metabolic and protein engineering of a terpenoid biosynthetic pathway for overproduction and selectivity control
2010
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Proc. Natl. Acad. Sci. USA
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Substrate specificity of the CYC2 enzyme from Kitasatospora griseola: production of sclarene, biformene and novel bicyclic diterpenes by the enzymatic reactions of labdane- and halimane-type diterpene diphosphates
2010
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Modular pathway engineering of diterpenoid synthases and the mevalonic acid pathway for miltiradiene production
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J. Am. Chem. Soc.
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Enzymatic (13)C labeling and multidimensional NMR analysis of miltiradiene synthesized by bifunctional diterpene cyclase in Selaginella moellendorffii
2011
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J. Biol. Chem.
286
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Bifunctional cis-abienol synthase from Abies balsamea discovered by transcriptome sequencing and its implications for diterpenoid fragrance production
2012
Zerbe, P.; Chiang, A.; Yuen, M.; Hamberger, B.; Hamberger, B.; Draper, J.A.; Britton, R.; Bohlmann, J.
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Insights into diterpene cyclization from structure of bifunctional abietadiene synthase from Abies grandis
2012
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A functional genomics approach to tanshinone biosynthesis provides stereochemical insights
2009
Gao, W.; Hillwig, M.; Huango, L.; Cui, G.; Wang, X.; Kong, J.; Yang, B.; Peters, R.
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Evolution of conifer diterpene synthases: diterpene resin acid biosynthesis in lodgepole pine and jack pine involves monofunctional and bifunctional diterpene synthases
2013
Hall, D.; Zerbe, P.; Jancsik, S.; Quesada, A.; Dullat, H.; Madilao, L.; Yuen, M.; Bohlmann, J.
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Molecular evolution of the substrate specificity of ent-kaurene synthases to adapt to gibberellin biosynthesis in land plants
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Increasing complexity of a diterpene synthase reaction with a single residue switch
2008
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Characterization of two genes for the biosynthesis of abietane-type diterpenes in rosemary (Rosmarinus officinalis) glandular trichomes
2014
Brueckner, K.; Bozic, D.; Manzano, D.; Papaefthimiou, D.; Pateraki, I.; Scheler, U.; Ferrer, A.; de Vos, R.C.; Kanellis, A.K.; Tissier, A.
Phytochemistry
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Chemical diversity of labdane-type bicyclic diterpene biosynthesis in Actinomycetales microorganisms
2016
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Characterization of two genes for the biosynthesis of abietane-type diterpenes in rosemary (Rosmarinus officinalis) glandular trichomes
2014
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Phytochemistry
101
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Functional diversification of kaurene synthase-like genes in Isodon rubescens
2017
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Plant Physiol.
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Biosynthesis of the oxygenated diterpene nezukol in the medicinal plant Isodon rubescens is catalyzed by a pair of diterpene synthases
2017
Pelot, K.A.; Hagelthorn, D.M.; Addison, J.B.; Zerbe, P.
PLoS ONE
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Characterization and evolutionary analysis of ent-kaurene synthase like genes from the wild rice species Oryza rufipogon
2016
Toyomasu, T.; Miyamoto, K.; Shenton, M.R.; Sakai, A.; Sugawara, C.; Horie, K.; Kawaide, H.; Hasegawa, M.; Chuba, M.; Mitsuhashi, W.; Yamane, H.; Kurata, N.; Okada, K.
Biochem. Biophys. Res. Commun.
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Insights into the bifunctional aphidicolan-16-beta-ol synthase through rapid biomolecular modeling approaches
2018
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Front. Chem.
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Heterologous expression of the isopimaric acid pathway in Nicotiana benthamiana and the effect of N-terminal modifications of the involved cytochrome P450 enzyme
2015
Gnanasekaran, T.; Vavitsas, K.; Andersen-Ranberg, J.; Nielsen, A.Z.; Olsen, C.E.; Hamberger, B.; Jensen, P.E.
J. Biol. Eng.
9
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Efficient diterpene production in yeast by engineering Erg20p into a geranylgeranyl diphosphate synthase
2015
Ignea, C.; Trikka, F.; Nikolaidis, A.; Georgantea, P.; Ioannou, E.; Loupassaki, S.; Kefalas, P.; Kanellis, A.; Roussis, V.; Makris, A.; Kampranis, S.
Metab. Eng.
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Heterologous production of levopimaric acid in Saccharomyces cerevisiae
2018
Liu, T.; Zhang, C.; Lu, W.
Microb. Cell Fact.
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The terpene synthase gene family in Tripterygium wilfordii harbors a labdane-type diterpene synthase among the monoterpene synthase TPS-b subfamily
2017
Hansen, N.L.; Heskes, A.M.; Hamberger, B.; Olsen, C.E.; Hallstroem, B.M.; Andersen-Ranberg, J.; Hamberger, B.
Plant J.
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Identification and functional characterization of diterpene synthases for triptolide biosynthesis from Tripterygium wilfordii
2018
Su, P.; Guan, H.; Zhao, Y.; Tong, Y.; Xu, M.; Zhang, Y.; Hu, T.; Yang, J.; Cheng, Q.; Gao, L.; Liu, Y.; Zhou, J.; Peters, R.J.; Huang, L.; Gao, W.
Plant J.
93
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Towards elucidating carnosic acid biosynthesis in Lamiaceae Functional characterization of the three first steps of the pathway in Salvia fruticosa and Rosmarinus officinalis
2015
Bozic, D.; Papaefthimiou, D.; Brueckner, K.; de Vos, R.C.; Tsoleridis, C.A.; Katsarou, D.; Papanikolaou, A.; Pateraki, I.; Chatzopoulou, F.M.; Dimitriadou, E.; Kostas, S.; Manzano, D.; Scheler, U.; Ferrer, A.; Tissier, A.; Makris, A.M.; Kampranis, S.C.; Kanellis, A.K.
PLoS ONE
10
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