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Ligand 2-methoxyestradiol Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C1 9 H2 6 O3
2-methoxyestradiol
CQOQDQWUFQDJMK-IWYKZDANSA-N
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)
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3'-phosphoadenylyl sulfate + 2-methoxyestradiol = adenosine 3',5'-bisphosphate + ?
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Substrate in Enzyme-catalyzed Reactions (1 result)
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3'-phosphoadenylyl sulfate + 2-methoxyestradiol = adenosine 3',5'-bisphosphate + ?
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Product in Enzyme-catalyzed Reactions (3 results)
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2-methoxyestrone + NADH = 2-methoxyestradiol + NAD+
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2-hydroxyestradiol + S-adenosyl-L-methionine = 2-methoxyestradiol + S-adenosyl-L-homocysteine
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2-hydroxyestradiol + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + 2-methoxyestradiol + 2-hydroxy-3-methoxyestradiol
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Activator in Enzyme-catalyzed Reactions (1 result)
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increases the enzyme activity 2fold at 100 nM
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Enzyme Kinetic Parameters
References & Links Literature References (3)
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Sulfotransferase (SULT) 1A1 polymorphic variants *1, *2, and *3 are associated with altered enzymatic activity, cellular phenotype, and protein degradation
2006
Nagar, S.; Walther, S.; Blanchard, R.L.
Mol. Pharmacol.
69
2084-2092
Pharmacogenetics of human cytosolic sulfotransferases
2006
Nowell, S.; Falany, C.N.
Oncogene
25
1673-1678
2-Methoxyestradiol and multidrug resistance: can 2-methoxyestradiol chemosensitize resistant breast cancer cells?
2009
Azab, S.S.; Salama, S.A.; Abdel-Naim, A.B.; Khalifa, A.E.; El-Demerdash, E.; Al-Hendy, A.
Breast Cancer Res. Treat.
113
9-19
Links to other databases for 2-methoxyestradiol