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Ligand 5-bromocytosine

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Substrate (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.17.3.2

6-amino-5-bromo-1H-pyrimidin-2-one + H2O + O2 = ?

686525

-

3.5.4.1

5-bromocytosine + H2O = 5-bromouracil + NH3

209486, 209495

-

Product in Enzyme-catalyzed Reactions (3 results)

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Show Product (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.11.1.18

Br- + H2O2 + cytosine = 5-bromocytosine + H2O

0

-

1.11.1.18

cytosine + Br- + peracetic acid = 5-bromocytosine + ?

0

-

1.11.1.18

Mops + Br- + peracetic acid = 5-bromocytosine + ?

0

-

1.11.1.18

3 entries

Enzyme Kinetic Parameters

K_M Value (2 results)

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Show KM Value (2 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.17.3.2

0.0325

-

-

686525

3.5.4.1

0.117

-

-

209495

References & Links

Literature References (3)

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BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

209486

-

Cytosine

1974

Holldorf, A.W.

Methods Enzym. Anal. , 3rd Ed. (Bergmeyer, H. U. , ed. )

3

1964-1966

209495

3516692

Inhibition of yeast cytosine deaminase by 5-bromo-2-pyrimidinone and its covalent hydrate

1986

Kornblatt, M.J.; Tee, O.S.

Eur. J. Biochem.

756

297-300

686525

17870212

Xanthine oxidase-activated prodrugs of thymidine phosphorylase inhibitors

2008

Reigan, P.; Gbaj, A.; Stratford, I.J.; Bryce, R.A.; Freeman, S.

Eur. J. Med. Chem.

43

1248-1260

Links to other databases for 5-bromocytosine

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Show Links (1 entry)

ChEBI

PubChem

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