Ligand prostaglandin E1

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Basic Ligand Information

Molecular Structure
Picture of prostaglandin E1 (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C20H34O5
prostaglandin E1
GMVPRGQOIOIIMI-DWKJAMRDSA-N
Synonyms:
(13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate, alprostadil, prostagladin E1, prostaglandin E-1

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + H2O + prostaglandin E1/in = ADP + phosphate + prostaglandin E1/out
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + H2O + prostaglandin E1/in = ADP + phosphate + prostaglandin E1/out
show the reaction diagram
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-

Substrate in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
prostaglandin E1 + NADPH = ?
show the reaction diagram
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prostaglandin E1 + NADPH + H+ = ?
show the reaction diagram
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prostaglandin E1 + NADP+ = 15-keto-prostaglandin E1 + NADPH + H+
show the reaction diagram
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prostaglandin E1 + [reduced NADPH-hemoprotein reductase] + O2 = 20-hydroxy-prostaglandin E1 + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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prostaglandin E1 + NADPH + O2 = ?
show the reaction diagram
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ATP + H2O + prostaglandin E1/in = ADP + phosphate + prostaglandin E1/out
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
prostaglandin F2alpha + NADP+ = prostaglandin E1 + NADPH
show the reaction diagram
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Prostaglandin H1 = Prostaglandin E1
show the reaction diagram
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ATP + H2O + prostaglandin E1/in = ADP + phosphate + prostaglandin E1/out
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activates
-
causes a modest elevation of PLD activity in resting platelets. prostaglandin E1-induced PLD activity is increased by 25% in the presence of Ca2+. Maximal activity at 5 micromol prostaglandin E1
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Inhibitor in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
inhibition of sodiumdodecylsulfate-induced activation in cell free extracts, 0.044 mM, 50% inhibition
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inhibits IKK
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inhibits the activating effect of thrombin; inhibits the activating effect of thrombin. Translocation to the plasma membrane of PLD1 is inhibited but only at high concentration
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (8 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (13 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.373
-
-
0.45
-
enzyme form CR8
0.157
-
-

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0139
-
-
0.0075
-
androsterone oxidation

References & Links

Links to other databases for prostaglandin E1

ChEBI
PubChem
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PubChem