Ligand N-arachidonoyl-dihydroceramide
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Basic Ligand Information
Molecular Structure

C38H69NO3
N-arachidonoyl-dihydroceramide
NXKPWQUXGKASPM-AJIQFNDCSA-N
N-(arachidoyl)-dihydrosphingosine, N-arachidonoyl-phytoceramide, N-arachidoyl-D-sphinganine, N-arachidoyl-dihydrosphingosine, N-arachidoylsphinganine
Roles as Enzyme Ligand
In Vivo Product in Enzyme-catalyzed Reactions (3 results)
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sphinganine + arachidoyl-CoA = N-arachidoylsphinganine + CoA
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D-erythro-sphinganine + arachidoyl-CoA = N-arachidoyl-D-sphinganine + CoA
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sphinganine + arachidoyl-CoA = N-arachidoylsphinganine + CoA
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Substrate in Enzyme-catalyzed Reactions (2 results)
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N-arachidonoyl-dihydroceramide + H2O = dihydrosphingosine + arachidonate
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N-arachidonoyl-phytoceramide + H2O = phytosphingosine + arachidonate
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Product in Enzyme-catalyzed Reactions (5 results)
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sphinganine + arachidoyl-CoA = N-arachidoylsphinganine + CoA
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D-erythro-sphinganine + arachidoyl-CoA = N-arachidoyl-D-sphinganine + CoA
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sphinganine + arachidoyl-CoA = N-arachidoylsphinganine + CoA
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arachidoyl-CoA + dihydrosphingosine = CoA + N-arachidoyl-dihydrosphingosine
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arachidoyl-CoA + dihydrosphingosine = N-(arachidoyl)-dihydrosphingosine + CoA
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Enzyme Kinetic Parameters
References & Links
Literature References (1)
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Alkaline ceramidase 3 (ACER3) hydrolyzes unsaturated long-chain ceramides, and its down-regulation inhibits both cell proliferation and apoptosis
2010
Hu, W.; Xu, R.; Sun, W.; Szulc, Z.M.; Bielawski, J.; Obeid, L.M.; Mao, C.
J. Biol. Chem.
285
7964-7976
Links to other databases for N-arachidonoyl-dihydroceramide