Ligand D-tyrosine

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Basic Ligand Information

Molecular Structure
Picture of D-tyrosine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C9H11NO3
D-tyrosine
OUYCCCASQSFEME-MRVPVSSYSA-N
Synonyms:
D-Tyr

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-tyrosine + O2 = dopaquinone + H2O
show the reaction diagram
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acetyl-CoA + D-tyrosine = CoA + N-acetyl-D-tyrosine
show the reaction diagram
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D-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)-2-oxopropanoate + D-glutamate
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (30 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-tyrosine + NADPH + H+ + ATP = D-tyrosinal + NADP+ + AMP + diphosphate
show the reaction diagram
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S-adenosyl-L-methionine + D-tyrosine = S-adenosyl-L-homocysteine + 3-methyl-D-tyrosine
show the reaction diagram
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acetyl-CoA + D-tyrosine = CoA + N-acetyl-D-tyrosine
show the reaction diagram
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D-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)-2-oxopropanoate + D-glutamate
show the reaction diagram
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3'-phosphoadenylylsulfate + D-tyrosine = adenosine 3',5'-bisphosphate + D-tyrosyl sulfate
show the reaction diagram
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D-tyrosine + H2O = phenol + pyruvate + NH3
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (15 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-Tyr ethyl ester + H2O = D-Tyr + ethanol
show the reaction diagram
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D-tyrosine-tRNA + H2O = D-tyrosine + tRNA
show the reaction diagram
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D-tyrosine methyl ester + H2O = D-tyrosine + methanol
show the reaction diagram
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D-Ala-D-Tyr + H2O = D-Ala + D-Tyr
show the reaction diagram
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-
N-carbamoyl-D-Tyr + H2O = D-Tyr + NH3 + CO2
show the reaction diagram
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-
ATP + L-Tyr + H2O = AMP + diphosphate + D-Tyr
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
best activator, activation constant of 0.0071 mM
-
activation
-
activity stimulated by, reaction rate 102%
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Inhibitor in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
9% inhibition with tyrosine at 3 mM and D-tyrosine at 12 mM
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3D Structure of Enzyme-Ligand-Complex (PDB) (23 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (27 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.16
-
at pH 7.5 and 37°C

KM Value (34 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.22
-
at pH 7.5 and 37°C

Ki Value (3 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
1.3
-
-
1.58
-
-
0.265
-
at pH 8.0 and 60°C

References & Links

Links to other databases for D-tyrosine

ChEBI
PubChem
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PubChem