Ligand D-Glucose 1,6-bisphosphate

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Basic Ligand Information

Molecular Structure
Picture of D-Glucose 1,6-bisphosphate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H14O12P2
D-Glucose 1,6-bisphosphate
RWHOZGRAXYWRNX-GASJEMHNSA-N
Synonyms:
D-glucose-1,6-bisphosphate, D-glucose 1,6-diphosphate, glucose 1,6-bisphosphate, glucose 1,6-diphosphate
Pathway Source
Pathways

Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + D-glucose 1-phosphate = ADP + D-glucose 1,6-bisphosphate
show the reaction diagram
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3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate = 3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
phosphate + D-glucose 1,6-bisphosphate = ?
show the reaction diagram
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GTP + D-glucose 1,6-diphosphate = diphosphate + ?
show the reaction diagram
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glucose 1,6-diphosphate + H2O = phosphate + ?
show the reaction diagram
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D-glucose 1,6-bisphosphate = ?
show the reaction diagram
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D-glucose 1,6-diphosphate = ?
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + D-glucose 1-phosphate = ADP + D-glucose 1,6-bisphosphate
show the reaction diagram
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ATP + glucose 6-phosphate = ADP + glucose 1,6-bisphosphate
show the reaction diagram
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D-glucose 1-phosphate + D-glucose 1-phosphate = D-glucose + D-glucose 1,6-bisphosphate
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (34 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activates
-
slight activation
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AspP activity is strongly enhanced by D-glucose-1,6-bisphosphate
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Inhibitor in Enzyme-catalyzed Reactions (17 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
90% inhibition at 5 mM
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (2 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.18
-
pH 7.0, 37°C
0.74
-
in 41 mM 1,3-diaza-2,4-cyclopentadiene /HCl (pH 7.6), 5 mM MgCl2, at 25°C

KM Value (3 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.621
-
pH 7.0, 37°C
0.5
-
-
0.00103
-
in 41 mM 1,3-diaza-2,4-cyclopentadiene /HCl (pH 7.6), 5 mM MgCl2, at 25°C

Ki Value (9 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.85
-
-
0.23
-
25°C, pH 7.6, substrate inhibition at high concentrations

References & Links

Links to other databases for D-Glucose 1,6-bisphosphate

ChEBI
PubChem
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PubChem