Ligand L-dihydroorotate

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Basic Ligand Information

Molecular Structure
Picture of L-dihydroorotate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H6N2O4
L-dihydroorotate
UFIVEPVSAGBUSI-REOHCLBHSA-N
Synonyms:
(S)-4,5-dihydroorotate, (S)-dihydroorotate, dihydro-L-orotate, L-5,6-dihydroorotic acid, L-dihydroorotic acid, S-dihydroorotate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (52 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(S)-dihydroorotate + acceptor = orotate + reduced acceptor
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (24 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
orotate + NADPH = (S)-dihydroorotate + NADP+
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (225 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-dihydroorotate + H2O = ?
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (117 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
orotate + NADPH = (S)-dihydroorotate + NADP+
show the reaction diagram
-
orotate + ferricyanide = (S)-dihydroorotate + ferrocyanide
show the reaction diagram
-

Inhibitor in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive
-
competitive inhibition
-

3D Structure of Enzyme-Ligand-Complex (PDB) (49 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (43 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
2.1
-
-

KM Value (73 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

Ki Value (3 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
TABLE ID
4.5
-
pH 8.0, 30°C
33663

References & Links

Links to other databases for L-dihydroorotate

ChEBI
PubChem
ChEBI
PubChem