Ligand beta-glycinamide ribonucleotide

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Basic Ligand Information

Molecular Structure
Picture of beta-glycinamide ribonucleotide (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C7H15N2O8P
beta-glycinamide ribonucleotide
OBQMLSFOUZUIOB-SHUUEZRQSA-N
Synonyms:
1-N-(5-phospho-D-ribosyl)glycinamide, 5'-phosphoribosylglycinamide, 5-phospho-D-ribosylglycinamide, 5-phosphoribosylglycinamide, beta-5-phospho-D-ribosylglycinamide, glycinamide ribonucleotide, glycinamide ribotide, N1-(5-phospho-D-ribosyl)glycinamide


Show all pahtways known for Show all BRENDA pathways known for beta-glycinamide ribonucleotide

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (61 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
PROVEN IN VIVO REACTION
ENZYME 3D STRUCTURE
show the reaction diagram
ATP + formate + N1-(5-phospho-D-ribosyl)glycinamide = ADP + H+ + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide + phosphate
-

In Vivo Product in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
PROVEN IN VIVO REACTION
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (369 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE
show the reaction diagram
N5,N10-anhydroformyltetrahydrofolic acid + glycinamide ribonucleotide = N10-formyltetrahydrofolic acid + formylglycinamide ribonucleotide
-
show the reaction diagram
ATP + formate + N1-(5-phospho-D-ribosyl)glycinamide = ADP + H+ + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide + phosphate
-

Product in Enzyme-catalyzed Reactions (21 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE

3D Structure of Enzyme-Ligand-Complex (PDB) (306 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (10 results)

COMMENTARY
EC NUMBER
LITERATURE
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
chimeric enzyme GPG-N11 (hGART1-56/PurN57-131/hGART132-202)
0.293
-
chimeric enzyme GPX-M1 (hGART1-100/PurN101-212)
0.0662
-
chimeric enzyme GPX-M24 (hGART1-54/PurN55-212)
0.262
-
chimeric enzyme GPX-M55 (hGART1-56/PurN58-212)
0.63
-
chimeric enzyme PGX-B12 (PurN1-101/hGART102-202)
0.0262
-
mutant K170R
7.7
-
mutant N106Q
14
-
wild type enzyme
7.5
-
wild-type enzyme
0.0034
-
-
2.3
-

KM Value (37 results)

COMMENTARY
EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
LITERATURE
purN/purU hybrid enzyme
0.016
-
mutant H108A
0.054
-
mutant H108Q
0.018
-
mutant K170R
0.0018
-
mutant N106Q
0.0295
-
pH 7.5, dideazafolate as cofactor
0.0192
-
pH 7.5, tetrahydrofolate as cofactor
pH 8.5, dideazafolate as cofactor
0.0235
-
pH 8.5, tetrahydrofolate as cofactor
0.008
-
mutant D144A
0.029
-
purT gene product
0.0101
-
strain D144A
0.122
-
strain H108A
0.115
-
strain H121Q
0.414
-
wild type enzyme
0.0011
-
wild-type
wild-type enzyme
4
-
mutant B13
0.178
-
chimeric enzyme GPG-N11 (hGART1-56/PurN57-131/hGART132-202)
0.99
-
chimeric enzyme GPX-M1 (hGART1-100/PurN101-212)
4
-
chimeric enzyme GPX-M24 (hGART1-54/PurN55-212)
21
-
chimeric enzyme GPX-M55 (hGART1-56/PurN58-212)
12
-
chimeric enzyme PGX-B12 (PurN1-101/hGART102-202)
33
-
mutant 13N + 13C 1:1
0.19
-

References & Links

Links to other databases for beta-glycinamide ribonucleotide

ChEBI
PubChem
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PubChem