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Ligand dimethylsulfonioacetate Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C4 H8 O2 S
dimethylsulfonioacetate
PSBDWGZCVUAZQS-UHFFFAOYSA-N
dimethylacetothetin, Dimethylthetin, thetin
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
dimethylthetin + L-homocysteine = S-methylthioglycolate + L-methionine
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ATP + H2O + dimethylsulfonioacetate/out = ADP + phosphate + dimethylsulfonioacetate/in
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + H2O + dimethylsulfonioacetate/out = ADP + phosphate + dimethylsulfonioacetate/in
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Substrate in Enzyme-catalyzed Reactions (5 results)
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dimethylsulfonioacetate + DL-homocysteine = (methylsulfanyl)acetate + L-methionine
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dimethylthetin + L-homocysteine = S-methylthioglycolate + L-methionine
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dimethylacetothetin + L-homocysteine = ? + L-methionine
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L-Asp + dimethylsulfonioacetate = ?
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ATP + H2O + dimethylsulfonioacetate/out = ADP + phosphate + dimethylsulfonioacetate/in
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Product in Enzyme-catalyzed Reactions (1 result)
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ATP + H2O + dimethylsulfonioacetate/out = ADP + phosphate + dimethylsulfonioacetate/in
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Inhibitor in Enzyme-catalyzed Reactions (3 results)
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at 0.25 mM: 29% inhibition, at 2.5 mM: 82% inhibition
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at 2 mM: 79% inhibition; weak inhibitor, at 2 mM: 20% inhibition
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Enzyme Kinetic Parameters
KM Value (2 results)
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References & Links Literature References (7)
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Identification of the folate-binding proteins of rat liver mitochondria as dimethylglycine dehydrogenase and sarcosine dehydrogenase. Flavoprotein nature and enzymatic properties of the purified proteins
1981
Wittwer, A.J.; Wagner, C.
J. Biol. Chem.
256
4109-4115
Purification, kinetic properties, and cDNA cloning of mammalian betaine-homocysteine methyltransferase
1996
Garrow, T.A.
J. Biol. Chem.
271
22831-22838
Thetin-homocysteine transmethylase: some further characteristics of the enzyme from rat liver
1958
Maw, G.A.
Biochem. J.
70
168-173
Thetin-homocysteine transmethylase: a preliminary manometric study of the enzyme from rat liver
1956
Maw, G.A.
Biochem. J.
63
116-124
Liver betaine-homocysteine S-methyltransferase activity undergoes a redox switch at the active site zinc
2008
Castro, C.; Millian, N.S.; Garrow, T.A.
Arch. Biochem. Biophys.
472
26-33
Betaine-homocysteine S-methyltransferase-2 is an S-methylmethionine-homocysteine methyltransferase
2008
Szegedi, S.S.; Castro, C.C.; Koutmos, M.; Garrow, T.A.
J. Biol. Chem.
283
8939-8945
The compatible-solute-binding protein OpuAC from Bacillus subtilis: ligand binding, site-directed mutagenesis, and crystallographic studies
2008
Smits, S.H.; Hoeing, M.; Lecher, J.; Jebbar, M.; Schmitt, L.; Bremer, E.
J. Bacteriol.
190
5663-5671
Links to other databases for dimethylsulfonioacetate
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