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BRENDA support

Ligand diiodine

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Basic Ligand Information

Molecular Structure
Picture of diiodine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
I2
diiodine
PNDPGZBMCMUPRI-UHFFFAOYSA-N
Synonyms:
I-2, I2, Iodine
Pathway Source
Pathways

Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-lysine + iodine + O2 = N6-hydroxy-L-lysine + iodate + H2O
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2 KI + 2 H+ + H2O2 = I2 + 2 H2O + 2 K+
show the reaction diagram
-

Inhibitor in Enzyme-catalyzed Reactions (49 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
0.1 mM, 91% inhibition
-
DELTA12-desaturase system, enzymatic complex
-
0.5 mM, 80% inhibition, preincubation with hydroxylamine protects
-
86% residual activity at 5 mM
-
complete inactivation at 2.5 mol iodine per mol of subunit
-
0.1 mM, 20% inhibition
-
slight inhibition
-
1 mM, 30% inhibition
-
1 mM, 100% inhibition
-
inhibitor-2, an inhibitory regulator from rabbit skeletal muscle. I-2 is a much less potent inhibitor against PPZ1FL, which includes the about 160-amino-acid N-terminal IDP domain, as compared to the catalytic domain. The N-terminal domain likely masks one or more binding sites for I-2 but not the active site, as the PPZ1FL protein is fully susceptible to microcystin-LR inhibition and prevents PPZ1 inhibition by this protein inhibitor
-
strain L
-
relative activity 93%
-
2 mM, complete inhibition
-
complete inhibition, reversed by cytosine
-
0% residual activity at 0.01 mM, 45% residual activity at 0.001 mM
-

Metals and Ions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
stabilization
-

Enzyme Kinetic Parameters

IC50 Value (2 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE

References & Links

Links to other databases for diiodine

ChEBI
PubChem
ChEBI
PubChem