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Ligand (Man)3GlcNAc

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (3 results)

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Show Natural Product (3 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.2.1.24

alpha-D-Man-(1-2)-alpha-D-Man-(1-2)-alpha-D-Man-(1-3)-[alpha-D-Man-(1-2)-alpha-D-Man-(1-3)-[alpha-D-Man-(1-2)-alpha-D-Man-(1-6)]-alpha-D-Man-(1-6)]-beta-D-Man-(1-4)-beta-D-GlcNAc + 6 H2O = 6 alpha-D-mannopyranose + alpha-D-Man-(1-6)-[alpha-D-Man-(1-3)]-beta-D-Man-(1-4)-beta-D-GlcNAc

135997, 135974

-

3.2.1.24

alpha-D-Man-(1-2)-alpha-D-Man-(1-2)-alpha-D-Man-(1-3)-[alpha-D-Man-(1-6)-[alpha-D-Man-(1-2)-alpha-D-Man-(1-3)]-alpha-D-Man-(1-6)]-beta-D-Man-(1-4)-beta-D-GlcNAc + H2O = alpha-D-Man-(1-6)-[alpha-D-Man-(1-3)]-beta-D-Man-(1-4)-beta-D-GlcNAc + alpha-D-Man-(1-3)-[alpha-D-Man-(1-6)]-alpha-D-Man-(1-6)-beta-D-Man

135993

-

3.2.1.24

Man5GlcNAc + 2 H2O = Man3GlcNAc + 2 alpha-D-mannopyranose

135993

-

3.2.1.24

3 entries

Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Substrate (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.1.101

UDP-N-acetyl-D-glucosamine + Manalpha6(Manalpha3)Man-O-beta4-N-acetyl-D-glucosamine = UDP + ?

659864

-

3.2.1.114

(Man)3GlcNAc + H2O = ?

646582, 646626

-

Product in Enzyme-catalyzed Reactions (7 results)

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Show Product (7 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.2.1.113

Manalpha(1-6)(Manalpha(1-3))Manalpha(1-6)(Manalpha(1-3))Manbeta(1-4)GlcNAc + H2O = (Man)4GlcNAc + (Man)3GlcNAc + D-mannose

135998, 0

-

3.2.1.24

alpha-D-Man-(1-2)-alpha-D-Man-(1-2)-alpha-D-Man-(1-3)-[alpha-D-Man-(1-2)-alpha-D-Man-(1-3)-[alpha-D-Man-(1-2)-alpha-D-Man-(1-6)]-alpha-D-Man-(1-6)]-beta-D-Man-(1-4)-beta-D-GlcNAc + 6 H2O = 6 alpha-D-mannopyranose + alpha-D-Man-(1-6)-[alpha-D-Man-(1-3)]-beta-D-Man-(1-4)-beta-D-GlcNAc

135997, 135974

-

3.2.1.24

alpha-D-Man-(1-2)-alpha-D-Man-(1-2)-alpha-D-Man-(1-3)-[alpha-D-Man-(1-6)-[alpha-D-Man-(1-2)-alpha-D-Man-(1-3)]-alpha-D-Man-(1-6)]-beta-D-Man-(1-4)-beta-D-GlcNAc + H2O = alpha-D-Man-(1-6)-[alpha-D-Man-(1-3)]-beta-D-Man-(1-4)-beta-D-GlcNAc + alpha-D-Man-(1-3)-[alpha-D-Man-(1-6)]-alpha-D-Man-(1-6)-beta-D-Man

135993

-

3.2.1.24

Man5GlcNAc + 2 H2O = Man3GlcNAc + 2 alpha-D-mannopyranose

135993

-

3.2.1.96

(Man)3(GlcNAc)2-N-dansyl-Asn + H2O = GlcNAc-N-dansyl-Asn + (Man)3-GlcNAc

171706

-

3.2.1.96

(Man)3(GlcNAc)2Asn + H2O = (Man)3GlcNAc + GlcNAc-Asn

0

-

3.2.1.96

(Man)3(GlcNAc)2Asn-Ac + H2O = (Man)3GlcNAc + GlcNAc-Asn-Ac

0

-

3.2.1.24

3 entries

3.2.1.96

3 entries

Enzyme Kinetic Parameters

K_M Value (2 results)

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Show KM Value (2 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.4.1.101

2.7

-

-

659864

2.4.1.101

4.5

-

-

659864

2.4.1.101

2 entries

References & Links

Literature References (8)

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Show Reference (8 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

135974

1849817

Purification and characterization of a novel broad-specificity (alpha1-2, alpha1-3 and alpha1-6) mannosidase from rat liver

1991

Bonay, P.; Hughes, R.C.

Eur. J. Biochem.

197

229-238

135993

3902812

Characterization of a novel alpha-D-mannosidase from rat brain microsomes

1985

Tulsiani, D.R.P.; Touster, O.

J. Biol. Chem.

260

13081-13087

135997

6863271

Evidence for an alpha-mannosidase in endoplasmatic reticulum of rat liver

1983

Bischoff, J.; Kornfeld, R.

J. Biol. Chem.

258

7907-7910

135998

7061502

alpha-D-Mannosidases of rat liver Golgi membranes. Mannosidase II is the GlcNAcMAN5-cleaving enzyme in glycoprotein biosynthesis and mannosidases Ia and IB are the enzymes converting Man9 precursors to Man5 intermediates

1982

Tulsiani, D.R.P.; Hubbard, S.C.; Robbins, P.W.; Touster, O.

J. Biol. Chem.

257

3660-3668

171706

1027432

endo-beta-N-Acetylglucosaminidase from fig latex

1977

Chien, S.F.; Weinburg, R.; Li, S.C.; Li, Y.T.

Biochem. Biophys. Res. Commun.

76

317-323

646582

2560127

Glycoprotein processing enzymes of plants

1989

Kaushal, G.P.; Elbein, A.D.

Methods Enzymol.

179

452-475

646626

2139344

Purification to homogeneity and properties of mannosidase II from mung bean seedlings

1990

Kaushal, G.P.; Szumilo, T.; Pastuszak, I.; Elbein, A.D.

Biochemistry

29

2168-2176

659864

14579596

Use of synthetic oligosaccharide substrate analogs to map the active sites of N-acetylglucosaminyltransferases I and II

2003

Schachter, H.; Reck, F.; Paulsen, H.

Methods Enzymol.

363

459-475

Links to other databases for (Man)3GlcNAc

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Show Links (1 entry)

ChEBI

PubChem