Ligand (6R)-N10-formyltetrahydrofolate
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Basic Ligand Information
Molecular Structure

C20H23N7O7
(6R)-N10-formyltetrahydrofolate
AUFGTPPARQZWDO-YPMHNXCESA-N
(6 R)-N10-formyl-tetrahydrofolate, (6 R)-N10-formyltetrahydrofolate, (6R)-10-formyl-5,6,7,8-tetrahydropteroylglutamate, L-(+)-10-formyltetrahydrofolate
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (2 results)
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(6R)-N10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide = (6R)-tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
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ATP + (6R)-10-formyl-5,6,7,8-tetrahydropteroylglutamate + L-glutamate = ADP + phosphate + (6R)-10-formyl-5,6,7,8-tetrahydropteroyl-Glu2
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Inhibitor in Enzyme-catalyzed Reactions (1 result)
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excellent competitive inhibitor
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Enzyme Kinetic Parameters
kcat Value (Turnover Number) (4 results)
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KM Value (4 results)
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0.002
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pH 8.9, 37ยบC, L1210 isoform
0.0029
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pH 8.9, 37ยบC, liver isoform
References & Links
Literature References (4)
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L(-)-10-formyltetrahydrofolate is the cofactor for glycinamide ribonucleotide transformylase from chicken liver
1981
Smith, G.K.; Benkovic, P.A.; Benkovic, S.J.
Biochemistry
20
4034-4036
Subcloning, characterization, and affinity labeling of Escherichia coli glycinamide ribonucleotide transformylase
1990
Inglese, J.; Johnson, D.L.; Shiau, A.; Smith, J.M.; Benkovic, S.J.
Biochemistry
29
1436-1443
An antibody probe to determine the native species of glycinamide ribonucleotide transformylase in chicken liver
1984
Young, M.; Sammons, R.D.; Mueller, W.T.; Benkovic, S.J.
Biochemistry
23
3979-3986
Mouse folylpoly-gamma-glutamate synthetase isoforms respond differently to feedback inhibition by folylpolyglutamate cofactors
2002
Andreassi, J.L.2nd.; Moran, R.G.
Biochemistry
41
226-235
Links to other databases for (6R)-N10-formyltetrahydrofolate