Ligand lacto-N-biose

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Basic Ligand Information

Molecular Structure
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Molecular Formula
BRENDA Name
InChIKey
C14H25NO11
lacto-N-biose
HMQPEDMEOBLSQB-LODBTCKLSA-N
Synonyms:
2-acetamido-2-deoxy-3-O-(beta-D-galactopyranosyl)-D-glucopyranose, beta-D-Gal-(1-->3)-D-GlcNAc, beta-D-Gal-(1-3)-D-GlcNAc, beta-D-Gal-(1->3)-beta-D-GlcNAc, beta-D-Gal-(1->3)-beta-GlcNAc, beta-D-Gal-(1->3)-D-GlcNAc, beta-D-galactopyranosyl-(1-3)-N-acetyl-D-glucosamine, beta-D-galactopyranosyl-(1->3)-N-acetyl-D-glucosamine, beta-D-galactopyranosyl-1,3-N-acetyl-D-glucosamine, beta-D-galactopyranosyl-1,3-N-acetyl-D-glucosoamine, beta-D-galactosido-(1,3)-N-acetylglucosamine, beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosamine, beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine, beta-D-galactosyl-1,3-N-acetyl-beta-D-glucosamine, beta-D-galactosyl-1,3-N-acetyl-D-glucosamine, beta D-galactosido-(1,3)-N-acetylglucosamine, D-Gal-beta-(1->3)-D-GlcNAc, D-galactosyl-beta-1,3-N-acetyl-D-glucosamine, Gal(beta1-3)GlcNAc, Gal-beta-(1->3)-GlcNAc, Gal-beta-1,3GlcNAc, Galbeta(1,3)GlcNAc, Galbeta(1-3)GlcNAc, Galbeta(1->3)GlcNAc, Galbeta1,3GlcNAc, Galbeta1-3GlcNAc

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

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EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
GDP-beta-L-colitose + beta-D-galactopyranosyl-(1->3)-N-acetyl-D-glucosamine = GDP + alpha-L-colitosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine
show the reaction diagram
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GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosamine = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
show the reaction diagram
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GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosamine = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (3 results)

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EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (24 results)

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EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
GDP-L-fucose + Galbeta(1,3)GlcNAc = GDP + ?
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (17 results)

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EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
UDP-galactose + N-acetyl-D-glucosamine = UDP + beta-D-galactosyl-1,3-N-acetyl-D-glucosamine
show the reaction diagram
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alpha-D-galactopyranose 1-phosphate + N-acetyl-D-glucosamine = beta-D-galactopyranosyl-(1->3)-N-acetyl-D-glucosamine + phosphate
show the reaction diagram
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L-Fuc-alpha-(1->4)-[D-Gal-beta-(1->3)]-D-GlcNAc + H2O = L-fucose + D-Gal-beta-(1->3)-D-GlcNAc
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (2 results)

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EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
22% inhibition of recombinant GlcAT-P and 77.3% of recombinant GlcAT-S at 5 mM
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (3 results)

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EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.087
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pH 8.0, 37°C

KM Value (20 results)

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EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
1.4
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pH 8.0, 37°C
0.75
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pH 6.4, 37°C

References & Links

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Links to other databases for lacto-N-biose

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ChEBI
PubChem
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PubChem