Ligand potassium cyanide

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

Basic Ligand Information

Molecular Structure

CKN

potassium cyanide

NNFCIKHAZHQZJG-UHFFFAOYSA-N

Download

Synonyms:

KCN

close all tables

open all tables

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (18 results)

top print hide

2.5.1.49

10 entries

2.8.1.5

KCN + dithioerythritol = ?

potassium cyanide + 2 H2O = potassium carbonate + NH3

777084

3.5.5.7

potassium cyanide + H2O = ?

209747

4.4.1.9

3 entries

Activator in Enzyme-catalyzed Reactions (15 results)

0.1 mM, 37% increase

1 mM, relative activity 101%

18% activation at 0.5 mM

439040

1.14.14.96

2fold activation at 1-10 mM

slight

activation at 6.7 mM up to 10 mM when both alternative pathways to oxygen are inhibited

391087

1.4.3.2

enhances the lysine oxidase activity (177% activity at 1 mM (pH 5.5))

slight stimulatuion after 30 min of incubation

208818

3.5.1.91

slight activation at 1 mM

733172

5.6.1.6

without cAMP stimulation, KCN treatment increases CFTR Cl- conductance by 1.95fold, whereas after cAMP stimulation KCN treatment increases conductance by 13.7fold

698868

Inhibitor in Enzyme-catalyzed Reactions (384 results)

1 mM, 41% inhibition

25% inhibition of the reductive reaction at 2.5 mM; slight

286013

1.1.1.165

slight inhibition at 2 mM

286099

1.1.1.190

complete inhibition at 1 mM

286154

1.1.1.191

73% inhibition at 1 mM

15% inhibition at 1 mM

complete inhibition at 10 mM

389504

1.1.1.306

55% inhibition at 2 mM

weak inhibition

65.2% inhibition at 1 mM, complete inhibition at 10 mM

287612

1.1.3.49

1 mM, 12.7% residual activity

1 mM, 23% inhibition

complete inhibition

complete inhibition at 1 mM

1 mM inhibits

28% residual activity at 100 mM

740389

1.1.99.36

2 mM, 90% inhibition; 90% inhibition at 2 mM

70% inhibition at 5 mM

0.05 mM, complete inhibition of bromoperoxidase-catalase activity

0.01 mM, 50% inhibition

348343

1.11.1.B8

0.1 mM, 82% inhibition

60-70% inhibition at 10 mM

85% inhibition at 0.1 mM

largely irreversible losses

strongly

little or no effect

40% inhibition at 2 mM

1 mM, 52% inhibition

70% inhibition at 10 mM

78.7% inhibition at 0.5 mM

0.1 mM

5 mM, 80% residual activity

10 mM, 21% loss of activity

348373

1.14.14.92

30 mM, 21% inhibition

slight inhibitor

pMMO

1 mM, loss of most of the desaturase activity

83% inhibition by 1 mM, 95% inhibition by 5 mM

658905

1.14.19.76

5 mM, 42% loss of activity

5 mM, 63% inhibition

25% inhibition

60% inhibition

0.1 mM, 20% inhibition

isozymes A and C

10-20% inhibition at 1 mM

1 mM causes 33% inhibition

13% residual activity at 1 mM

741188

1.2.3.3

25% inhibition at 10 mM

390437

1.2.3.4

41% activity retained at 5 mM concentration

288379

1.2.3.5

20 mM concentration 25% inhibition

288396

1.2.3.7

complete inhibition at 20 mM after 1 h incubation at room temperature

5 mM, 64% inhibition

1 mM, 26% inhibition

complete inhibition of orotate reductase reaction

protection by FAD

inhibition with all cofactors except the methyl viologen dependent activity

1 mM, 24% inhibition

89% inhibition at 20 mM

50 mM, strong inhibition of isozymes 1-3

391622

1.4.1.5

0.1 mM, 50% inhibition

1 mM, 43% inhibition

47% inhibition at 7.1 mM

remarkable inhibition at 1 mM, inhibition is only slight with 2,6-dichlorophenol-indophenol electron acceptor but higher when indophenol is used

slight inhibition

0.01 M, 10% inhibition

45% residual activity at 2 mM

392382

1.5.3.4

1.3 mM, about 40% inhibition

392428, 485480

1.5.3.7

20% inhibition at 1 mM

392478

1.5.5.2

very strong inhibition

741588

1.7.1.1

0.1 mM, complete inhibition

although 1 mM KCN completely inhibits hydroxylamine reduction, it does not inhibit the reduction of K3Fe(CN)6 and only decreases the rate of cytochrome c reduction by 12%

0.1 mM, 84% inhibition; 1 mM, 100%

1 mM, complete inhibition

697689

1.8.1.2

complete inhibition at 1 mM

656421

1.8.2.1

2 mM, complete inhibition after 10 min

inhibits groth on iodate and iodate reduction completely

764582

2.1.1.159

88% inhibition at 100 mM, 44% inhibition at 10 mM

670507

2.1.1.160

74% inhibition at 100 mM, but 33% activation at 10 mM

1 mM, 26% inhibition

weak

58% inhibition at 0.1 M

488405

2.4.2.51

13% inhibition at 0.1 mM

15.6% inhibition by 1 mM

10 mM, almost complete inhibition

100 mM, complete

weak inhibition

1 mM, 38% inhibition

1 mM, 93% inhibition, pyridoxal 5'-phosphate protects

1 mM: 22% inhibition

complete inhibition

irreversible inhibitor

640191

2.6.1.75

1 mM, 38% remaining activity for CAT 1, less efficient inhibitor for CAT-IIA and CAT-IIB

little effect

62% inhibition at 1 mM

62% inhibition of the catalytic fragment of CNP1

652106

3.1.6.1

10 mM, 23% residual activity

slight

25 mM, 70% inhibition

10 mM, 84% inhibition

similar effect as with imidazole, hemoglobin hydrolysis inhibited, cleavage of small synthetic peptide and ester substrates enhanced

10 mM, 42% inhibition

171984

3.5.1.38

slight inhibition at 8 mM

209101

3.5.1.73

10 mM, 12% loss of activity

KCN inhibits dihydropterin deaminase activity strongly 98.6% inhibition at 10 mM whereas it has almost no inhibitory effect on guanine deaminase activity at the same concentration

weak

strong inhibitor

non-competitive

1 mM, 68% inhibition

1 mM, 26% inhibition

20% inhibition at 1 mM, 40% inhibition at 5-10 mM

10 mM almost complete inhibition

22% inhibition at 1 mM

19% residual activity at 1 mM

1 mM, 32% inhibition

1 mM, 76% inhibition

Metals and Ions (12 results)

raises dehydrogenase activity of freshly prepared kidney extracts

287839

1.14.14.91

1 mM, increase to 125% of the activity

348373

2.1.1.160

74% inhibition at 100 mM, but 33% activation at 10 mM

slight stimulation

slight activation of cyclic phosphodiesterase

135199

3.2.1.1

10 mM, 82% inhibition

activates

5 mM, 1.8fold activation, substrate: nenzonitrile

756766

4.8.1.3

activates at 0.001-0.1 mM, inhibits at 1-10 mM

648796

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (2 results)

top print hide

4.4.1.9

2 entries

K_M Value (8 results)

top print hide

2.8.1.5

pH 9, 37°C, with dithioerythritol as second substrate

0.75

0.75

pH 7.0, 37°C, partially purified enzyme

209747

4.4.1.9

5 entries

K_i Value (21 results)

7.5

pH 8.4, 80°C

0.005

2.6

IC₅₀ Value (7 results)

0.3

at 37°C

0.21

0.0064

in 25 mM potassium phosphate (pH 7.5), at 30°C

714285

References & Links

top

Show Reference (454 entries)

Links to other databases for potassium cyanide

Ligand potassium cyanide

Basic Ligand Information

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (18 results)

Activator in Enzyme-catalyzed Reactions (15 results)

Inhibitor in Enzyme-catalyzed Reactions (384 results)

Metals and Ions (12 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (2 results)

KM Value (8 results)

Ki Value (21 results)

IC50 Value (7 results)

References & Links

Literature References (454)

Links to other databases for potassium cyanide

k_cat Value (Turnover Number) (2 results)

K_M Value (8 results)

K_i Value (21 results)

IC₅₀ Value (7 results)