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Branched-chain ketoacid dehydrogenase
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Inhibition of the bovine branched-chain 2-oxo acid dehydrogenase complex and its kinase by arylidenepyruvates
1990
Lau, K.S.; Cooper, A.J.L.; Chuang, D.T.
Biochim. Biophys. Acta
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Purification of branched-chain keto acid dehydrogenase and lipoamide dehydrogenase-valine from Pseudomonas
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Purification of a branched-chain keto acid dehydrogenase from Pseudomonas putida
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Purification, resolution, and reconstitution of rat liver branched-chain alpha-keto acid dehydrogenase complex
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Role of branched-chain 2-oxo acid dehydrogenase and pyruvate dehydrogenase in 2-oxobutyrate metabolism
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Isolation of a branched chain alpha-keto acid dehydrogenase from rabbit liver
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Isolation of rabbit liver branched chain alpha-ketoacid dehydrogenase and regulation by phosphorylation
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Stabilization of mammalian liver branched-chain alpha-ketoacid dehydrogenase by thiamin pyrophosphate
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Oxidative decarboxylation of branched-chain 2-oxo fatty acids by higher plant peroxisomes
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Branched chain 2-oxo-acid dehydrogenase complex of rat liver
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Reversible inactivation of alpha-ketoglutarate dehydrogenase in response to alterations in the mitochondrial glutathione status
2003
Nulton-Persson, A.C.; Starke, D.W.; Mieyal, J.J.; Szweda, L.I.
Biochemistry
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Amino-terminal residues 1-45 of the Escherichia coli pyruvate dehydrogenase complex E1 subunit interact with the E2 subunit and are required for activity of the complex but not for reductive acetylation of the E2 subunit
2004
Park, Y.H.; Wei, W.; Zhou, L.; Nemeria, N.; Jordan, F.
Biochemistry
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Inhibition of the alpha-ketoglutarate dehydrogenase complex alters mitochondrial function and cellular calcium regulation
2003
Huang, H.M.; Zhang, H.; Xu, H.; Gibson, G.E.
Biochim. Biophys. Acta
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Inhibition of the alpha-ketoglutarate dehydrogenase and pyruvate dehydrogenase complexes by a putative aberrant metabolite of serotonin, tryptamine-4,5-dione
2002
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Chem. Res. Toxicol.
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Roles of His291-alpha and His146-beta' in the reductive acylation reaction catalyzed by human branched-chain alpha-ketoacid dehydrogenase: refined phosphorylation loop structure in the active site
2003
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Oxidative alpha-ketoglutarate dehydrogenase inhibition via subtle elevations in monoamine oxidase B levels results in loss of spare respiratory capacity: implications for Parkinson's disease
2003
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Cross-talk between thiamin diphosphate binding and phosphorylation loop conformation in human branched-chain alpha-keto acid decarboxylase/dehydrogenase
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Regulation of 2-oxoglutarate (alpha-ketoglutarate) dehydrogenase stability by the RING finger ubiquitin ligase Siah
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Ligand-induced conformational changes and a reaction intermediate in branched-chain 2-oxo acid dehydrogenase (E1) from Thermus thermophilus HB8, as revealed by X-ray crystallography
2004
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Catalytic domain of Salmonella typhimurium 2-oxoglutarate dehydrogenase is localized in N-terminal region
2003
Kim, C.H.
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Kinetic and spectral investigation of allosteric interaction of coenzymes with 2-oxo acid dehydrogenase complexes
2002
Strumilo, S.; Czygier, M.; Kondracikowska, J.; Dobrzyn, P.; Czerniecki, J.
J. Mol. Struct.
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Inhibition of the alpha-ketoglutarate dehydrogenase complex by the myeloperoxidase products, hypochlorous acid and mono-N-chloramine
2005
Jeitner, T.M.; Xu, H.; Gibson, G.E.
J. Neurochem.
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Generation of reactive oxygen species in the reaction catalyzed by alpha-ketoglutarate dehydrogenase
2004
Tretter, L.; Adam-Vizi, V.
J. Neurosci.
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Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species
2004
Starkov, A.A.; Fiskum, G.; Chinopoulos, C.; Lorenzo, B.J.; Browne, S.E.; Patel, M.S.; Beal, M.F.
J. Neurosci.
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The human malaria parasite Plasmodium falciparum possesses two distinct dihydrolipoamide dehydrogenases
2005
McMillan, P.J.; Stimmler, L.M.; Foth, B.J.; McFadden, G.I.; Mueller, S.
Mol. Microbiol.
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Overexpression of a bacterial branched-chain alpha-keto acid dehydrogenase complex in Arabidopsis results in accumulation of branched-chain acyl-CoAs and alteration of free amino acid composition in seeds
2003
Li, L.; Thipyapong, P.; Breeden, D.C.; Steffens, J.C.
Plant Sci.
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Phosphonate analogues of alpha-ketoglutarate inhibit the activity of the alpha-ketoglutarate dehydrogenase complex isolated from brain and in cultured cells
2005
Bunik, V.I.; Denton, T.T.; Xu, H.; Thompson, C.M.; Cooper, A.J.; Gibson, G.E.
Biochemistry
44
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Short-term regulation of the alpha-ketoglutarate dehydrogenase complex by energy-linked and some other effectors
2005
Strumilo, S.
Biochemistry
70
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Differential requirements of calcium for oxoglutarate dehydrogenase and mitochondrial nitric-oxide synthase under hypoxia: Impact on the regulation of mitochondrial oxygen consumption
2005
Solien, J.; Haynes, V.; Giulivi, C.
Comp. Biochem. Physiol. A
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Proteins of the glycine decarboxylase complex in the hydrogenosome of Trichomonas vaginalis
2006
Mukherjee, M.; Brown, M.T.; McArthur, A.G.; Johnson, P.J.
Eukaryot. Cell
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Brain pyruvate and 2-oxoglutarate dehydrogenase complexes are mitochondrial targets of the CoA ester of the Refsum disease marker phytanic acid
2006
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The alpha-ketoglutarate-dehydrogenase complex: a mediator between mitochondria and oxidative stress in neurodegeneration
2005
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Mol. Neurobiol.
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Glycine decarboxylase mutations: a distinctive phenotype of nonketotic hyperglycinemia in adults
2005
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Neurology
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alpha-Ketoglutarate dehydrogenase: a target and generator of oxidative stress
2005
Tretter, L.; Adam-Vizi, V.
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The glycine decarboxylase complex is not essential for the cyanobacterium Synechocystis sp. strain PCC 6803
2005
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2006
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Reversible inhibition of alpha-ketoglutarate dehydrogenase by hydrogen peroxide: glutathionylation and protection of lipoic acid
2008
Applegate, M.A.; Humphries, K.M.; Szweda, L.I.
Biochemistry
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Novel functions of the alpha-ketoglutarate dehydrogenase complex may mediate diverse oxidant-induced changes in mitochondrial enzymes associated with Alzheimers disease
2008
Shi, Q.; Xu, H.; Kleinman, W.A.; Gibson, G.E.
Biochim. Biophys. Acta
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The 2-oxoacid dehydrogenase multi-enzyme complex of the archaeon Thermoplasma acidophilum - recombinant expression, assembly and characterization
2007
Heath, C.; Posner, M.G.; Aass, H.C.; Upadhyay, A.; Scott, D.J.; Hough, D.W.; Danson, M.J.
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Branched chain alpha-keto acid dehydrogenase, E1-beta subunit gene is associated with premature ovarian failure
2008
Kang, H.; Lee, S.K.; Cho, S.W.; Lee, S.H.; Kwack, K.
Fertil. Steril.
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Crystal structure of the E1 component of the Escherichia coli 2-oxoglutarate dehydrogenase multienzyme complex
2007
Frank, R.A.; Price, A.J.; Northrop, F.D.; Perham, R.N.; Luisi, B.F.
J. Mol. Biol.
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Responses of the mitochondrial alpha-ketoglutarate dehydrogenase complex to thiamine deficiency may contribute to regional selective vulnerability
2007
Shi, Q.; Karuppagounder, S.S.; Xu, H.; Pechman, D.; Chen, H.; Gibson, G.E.
Neurochem. Int.
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Structure-function relationships in the 2-oxo acid dehydrogenase family: substrate-specific signatures and functional predictions for the 2-oxoglutarate dehydrogenase-like proteins
2008
Bunik, V.I.; Degtyarev, D.
Proteins
71
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Metabolic control exerted by the 2-oxoglutarate dehydrogenase reaction: a cross-kingdom comparison of the crossroad between energy production and nitrogen assimilation
2009
Bunik, V.I.; Fernie, A.R.
Biochem. J.
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Novel isoenzyme of 2-oxoglutarate dehydrogenase is identified in brain, but not in heart
2008
Bunik, V.; Kaehne, T.; Degtyarev, D.; Shcherbakova, T.; Reiser, G.
FEBS J.
275
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alpha-Ketoglutarate dehydrogenase and glutamate dehydrogenase work in tandem to modulate the antioxidant alpha-ketoglutarate during oxidative stress in Pseudomonas fluorescens
2009
Mailloux, R.J.; Singh, R.; Brewer, G.; Auger, C.; Lemire, J.; Appanna, V.D.
J. Bacteriol.
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Role of 2-oxoglutarate dehydrogenase in brain pathologies involving glutamate neurotoxicity
2009
Graf, A.; Kabysheva, M.; Klimuk, E.; Trofimova, L.; Dunaeva, T.; ZĂÂ1/4ndorf, G.; Kahlert, S.; Reiser, G.; Storozhevykh, T.; Pinelis, V.; Sokolova, N.; Bunik, V.
J. Mol. Catal. B
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Mild reduction in the activity of the alpha-ketoglutarate dehydrogenase complex elevates GABA shunt and glycolysis
2009
Shi, Q.; Risa, O.; Sonnewald, U.; Gibson, G.E.
J. Neurochem.
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Inhibition of the alpha-ketoglutarate dehydrogenase-mediated reactive oxygen species generation by lipoic acid
2009
Ambrus, A.; Tretter, L.; Adam-Vizi, V.
J. Neurochem.
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alpha-Ketoglutarate dehydrogenase contributes to production of reactive oxygen species in glutamate-stimulated hippocampal neurons in situ
2009
Zuendorf, G.; Kahlert, S.; Bunik, V.I.; Reiser, G.
Neuroscience
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Inhibition of 2-oxoglutarate dehydrogenase in potato tuber suggests the enzyme is limiting for respiration and confirms its importance in nitrogen assimilation,
2008
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Plant Physiol.
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Crystallization and preliminary X-ray diffraction analyses of the homodimeric glycine decarboxylase (P-protein) from the cyanobacterium Synechocystis sp. PCC 6803
2010
Hasse, D.; Hagemann, M.; Andersson, I.; Bauwe, H.
Acta Crystallogr. Sect. F
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Analysis of branched-chain alpha-keto acid dehydrogenase complex activity in rat tissues using alpha-keto[1-13C]isocaproate as substrate
2010
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The E2 domain of OdhA of Corynebacterium glutamicum has succinyltransferase activity dependent on lipoyl residues of the acetyltransferase AceF
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Crystal structure of aminomethyltransferase in complex with dihydrolipoyl-H-protein of the glycine cleavage system: implications for recognition of lipoyl protein substrate, disease-related mutations, and reaction mechanism
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Stimulation of rat liver branched-chain alpha-keto acid dehydrogenase activity by low doses of bezafibrate
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Knapik-Czajka, M.
Toxicology
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Glycine cleavage enzyme complex: molecular cloning and expression of the H-protein cDNA from cultured human skin fibroblasts
2011
Zay, A.; Choy, F.Y.; Patrick, C.; Sinclair, G.
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Glycine decarboxylase cleaves a malignant metabolic path to promote tumor initiation
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Dominy, J.; Vazquez, F.; Puigserver, P.
Cancer Cell
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Glycine decarboxylase controls photosynthesis and plant growth
2012
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2-Oxoglutarate dehydrogenase is a more significant source of O2(-)/H2O2 than pyruvate dehydrogenase in cardiac and liver tissue
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Free Radic. Biol. Med.
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Burst of succinate dehydrogenase and alpha-ketoglutarate dehydrogenase activity in concert with the expression of genes coding for respiratory chain proteins underlies short-term beneficial physiological stress in mitochondria
2013
Zakharchenko, M.; Zakharchenko, A.; Khunderyakova, N.; Tutukina, M.; Simonova, M.; Vasilieva, A.; Romanova, O.; Fedotcheva, N.; Litvinova, E.; Maevsky, E.; Zinchenko, V.; Berezhnov, A.; Morgunov, I.; Gulayev, A.; Kondrashova, M.
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Human 2-oxoglutarate dehydrogenase complex E1 component forms a thiamin-derived radical by aerobic oxidation of the enamine intermediate
2014
Nemeria, N.S.; Ambrus, A.; Patel, H.; Gerfen, G.; Adam-Vizi, V.; Tretter, L.; Zhou, J.; Wang, J.; Jordan, F.
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A novel regulatory mechanism based upon a dynamic core structure for the mitochondrial pyruvate dehydrogenase complex?
2014
Broz, A.K.; Tovar-Mendez, A.; Mooney, B.P.; Johnston, M.L.; Miernyk, J.A.; Randall, D.D.
Mitochondrion
19
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Recombinant expression, characterization and application of a dihydrolipoamide dehydrogenase with diaphorase activity from Bacillus sphaericus
2017
Kianmehr, A.; Mahdizadeh, R.; Oladnabi, M.; Ansari, J.
3 Biotech
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153
Glycine decarboxylase is an unusual amino acid decarboxylase involved in tumorigenesis
2014
Go, M.K.; Zhang, W.C.; Lim, B.; Yew, W.S.
Biochemistry
53
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A pH-dependent kinetic model of dihydrolipoamide dehydrogenase from multiple organisms
2014
Moxley, M.A.; Beard, D.A.; Bazil, J.N.
Biophys. J.
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Expression and biochemical characterization of alpha-ketoglutarate decarboxylase from cyanobacterium Synechococcus sp. PCC7002
2018
Lei, G.; Wang, X.; Lai, C.; Li, Z.M.; Zhang, W.; Xie, C.; Wang, F.; Wu, X.; Li, Z.
Int. J. Biol. Macromol.
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The human Krebs cycle 2-oxoglutarate dehydrogenase complex creates an additional source of superoxide/hydrogen peroxide from 2-oxoadipate as alternative substrate
2017
Nemeria, N.S.; Gerfen, G.; Guevara, E.; Nareddy, P.R.; Szostak, M.; Jordan, F.
Free Radic. Biol. Med.
108
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The Arabidopsis E1 subunit of the 2-oxoglutarate dehydrogenase complex modulates plant growth and seed production
2019
Condori-Apfata, J.A.; Batista-Silva, W.; Medeiros, D.B.; Vargas, J.R.; Valente, L.M.L.; Heyneke, E.; Perez-Diaz, J.L.; Fernie, A.R.; Araujo, W.L.; Nunes-Nesi, A.
Plant Mol. Biol.
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Engineering 2-oxoglutarate dehydrogenase to a 2-oxo aliphatic dehydrogenase complex by optimizing consecutive components
2020
Chakraborty, J.; Nemeria, N.; Zhang, X.; Nareddy, P.; Szostak, M.; Farinas, E.; Jordan, F.
AIChE J.
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Structure of the dihydrolipoamide succinyltransferase (E2) component of the human alpha-ketoglutarate dehydrogenase complex (hKGDHc) revealed by cryo-EM and cross-linking mass spectrometry Implications for the overall hKGDHc structure
2021
Nagy, B.; Polak, M.; Ozohanics, O.; Zambo, Z.; Szabo, E.; Hubert, A.; Jordan, F.; Novacek, J.; Adam-Vizi, V.; Ambrus, A.
Biochim. Biophys. Acta Gen. Subj.
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Oxoglutarate dehydrogenase and acetyl-CoA acyltransferase 2 selectively associate with H2A.Z-occupied promoters and are required for histone modifications
2019
Choi, S.; Pfleger, J.; Jeon, Y.H.; Yang, Z.; He, M.; Shin, H.; Sayed, D.; Astrof, S.; Abdellatif, M.
Biochim. Biophys. Acta Gene Regul. Mech.
1862
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Regulation of the alpha-ketoglutarate dehydrogenasecomplex during hibernation in a small mammal, the Richardsons ground squirrel (Urocitellus richardsonii)
2020
Green, S.R.; Storey, K.B.
Biochim. Biophys. Acta Proteins Proteom.
1868
140448
Structure optimization and bioactivity evaluation of ThDP analogs targeting cyanobacterial pyruvate dehydrogenase E1
2019
Feng, J.; He, H.; Zhou, Y.; Cai, M.; Peng, H.; Liu, H.; Liu, L.; Feng, L.; He, H.
Bioorg. Med. Chem.
27
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The mitochondrial 2-oxoadipate and 2-oxoglutarate dehydrogenase complexes share their E2 and E3 components for their function and both generate reactive oxygen species
2018
Nemeria, N.S.; Gerfen, G.; Nareddy, P.R.; Yang, L.; Zhang, X.; Szostak, M.; Jordan, F.
Free Radic. Biol. Med.
115
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Selective inhibition of 2-oxoglutarate and 2-oxoadipate dehydrogenases by the phosphonate analogs of their 2-oxo acid substrates
2021
Artiukhov, A.; Kazantsev, A.; Lukashev, N.; Bellinzoni, M.; Bunik, V.
Front. Chem.
8
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Functional expression of a bacterial alpha-ketoglutarate dehydrogenase in the cytosol of Saccharomyces cerevisiae
2019
Baldi, N.; Dykstra, J.C.; Luttik, M.A.H.; Pabst, M.; Wu, L.; Benjamin, K.R.; Vente, A.; Pronk, J.T.; Mans, R.
Metab. Eng.
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