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Ligand rifamycin SV

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

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Show Natural Product (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.1.1.315

S-adenosyl-L-methionine + 27-O-demethylrifamycin SV = S-adenosyl-L-homocysteine + rifamycin SV

0

-

Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Substrate (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.10.3.6

rifamycin SV + ? = ?

439882, 439884

-

1.14.13.211

rifamycin SV + NAD(P)H + O2 = ? + NAD(P)+ + H2O

764739

-

Product in Enzyme-catalyzed Reactions (1 result)

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Show Product (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.1.1.315

S-adenosyl-L-methionine + 27-O-demethylrifamycin SV = S-adenosyl-L-homocysteine + rifamycin SV

0

-

Inhibitor in Enzyme-catalyzed Reactions (6 results)

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Show Inhibitors (6 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.8.1.7

competitive inhibition

699224

-

2.7.7.19

-

642965

-

2.7.7.6

-

703147

-

2.7.7.8

-

643680

-

2.7.7.8

partial inhibition of polymerization

643698

-

2.7.7.8

2 entries

3.1.8.1

IC50 of 0.00265 mg/ml 6 h after the drug application

715744

-

3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

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Show 3D Structure of Enzyme-Ligand-Complex (PDB) (1 entry)

EC NUMBER

ENZYME 3D STRUCTURE

2.7.7.6

4oir, 3D-view

Enzyme Kinetic Parameters

K_i Value (1 result)

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Show KI Value (1 entry)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.8.1.7

0.275

-

at 25°C, pH 8.0

699224

IC₅₀ Value (1 result)

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Show IC50 Value (1 entry)

EC NUMBER

IC50 VALUE

IC50 VALUE MAXIMUM

COMMENTARY

LITERATURE

1.8.1.7

0.146

-

at 25°C, pH 8.0

699224

References & Links

Literature References (9)

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Show Reference (9 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

439882

6825839

Rifamycin B oxidase from Monocillium spp., a new type of diphenol oxidase

1983

Han, M.H.; Seong, B.L.; Son, H.J.; Mheen, T.I.

FEBS Lett.

151

36-40

439884

-

Enzymatic oxidation of rifamycins by a microorganism of the genus Humicola

1985

Seong, B.L.; Son, H.J.; Mheen, T.I.; Park, Y.H.; Han, M.H.

J. Ferment. Technol.

63

515-522

642965

10793710

Inhibition of poly(A) polymerase by rifamycin derivatives

1974

Jacob, S.T.; Rose, K.M.

Nucleic Acids Res.

1

1549-1559

643680

-

Polynucleotide phosphorylase

1982

Littauer, U.Z.; Soreq, H.

The Enzymes, 3rd. Ed. (Boyer, P. D. , ed. )

15B

517-553

643698

45489

Isolation and characterization of a polynucleotide phosphorylase from Bacillus amyloliquefaciens

1977

Erickson, R.J.; Grosch, J.C.

J. Bacteriol.

130

869-876

699224

18341267

Effects of some antibiotics on human erythrocyte glutathione reductase: an in vitro study

2008

Senturk, M.; Kufrevioglu, O.I.; Ciftci, M.

J. Enzyme Inhib. Med. Chem.

23

144-148

703147

18957193

Tie me up, tie me down: inhibiting RNA polymerase

2008

Sousa, R.

Cell

135

205-207

715744

20429781

Differential effects of some antibiotics on paraoxonase enzyme activity on human hepatoma cells (HepG2) in vitro

2010

Kockar, F.; Sinan, S.; Yildirim, H.; Arslan, O.

J. Enzyme Inhib. Med. Chem.

25

715-719

764739

32582048

Characterization of the rifamycin-degrading monooxygenase from rifamycin producers implicating its involvement in saliniketal biosynthesis

2020

Zheng, X.; Liu, X.; Peng, S.; Zhou, Q.; Xu, B.; Yuan, H.; Tang, G.

Front. Microbiol.

11

971

Links to other databases for rifamycin SV

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Show Links (1 entry)

ChEBI

PubChem