Ligand selenium

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Basic Ligand Information

Molecular Structure
Picture of selenium (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
H2Se
selenium
SPVXKVOXSXTJOY-UHFFFAOYSA-N
Synonyms:
H2Se, HSe-, hydrogen selenide, Se, selenide


Show all pahtways known for Show all BRENDA pathways known for selenium

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
S-adenosyl-L-methionine + selenium = S-adenosyl-L-homocysteine + ?
show the reaction diagram
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O-acetyl-L-serine + selenide = L-selenocysteine + acetate
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
selenite + NADH + H+ = selenium + H2O + NAD+
show the reaction diagram
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L-selenocysteine + reduced acceptor = selenide + L-alanine + acceptor
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
S-adenosyl-L-methionine + selenium = S-adenosyl-L-homocysteine + ?
show the reaction diagram
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O-acetyl-L-serine + selenide = L-selenocysteine + acetate
show the reaction diagram
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O-acetyl-Ser + selenide = selenocysteine + acetate
show the reaction diagram
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L-Seryl-tRNASec + selenide = ?
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(SeO3)2- + H2 + ? = Se + H2O + ?
show the reaction diagram
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Ac-YYTSPMSeCAPARSMLLTGN + S-adenosyl-L-methionine = Ac-YYTSPM-3-oxo-L-Ala-APARSMLLTGN + L-methionine + 5'-deoxyadenosine + sulfur dioxide + hydrogen selenide
show the reaction diagram
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SeO32- + a [DsrC protein]-dithiol + 2 reduced methyl viologen + 2 H+ = HSe- + a [DsrC protein]-disulfide + 2 oxidized methyl viologen + 3 H2O
show the reaction diagram
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selenite + NADH + H+ = selenium + H2O + NAD+
show the reaction diagram
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L-selenocysteine = L-alanine + selenium
show the reaction diagram
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L-selenocysteine = L-alanine + H2Se
show the reaction diagram
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L-selenodjenkolate = pyruvate + NH3 + H2Se + formaldehyde
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
sulfide, elemental sulfur, elemental selenium or hydroxylamine required in catalytic amount, inhibition when added over a critical concentration (with the exception of hydroxylamine)
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enzyme activity towards substrates (S)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]-pyrimidine and vanillin is increased by selenium deficiency to 250% of initial rate, and this corresponds to an increase of Aox1 protein level, but not to a decrease in mRNA level
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Metals and Ions (98 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
the enzyme contains selenomethionine. Incorporation of selenium into the enzyme occurs randomly and is not required for any specific function
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the large subunit contains a selenocysteine
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[NiFeSe]-hydrogenase
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enzyme from cells grown in selenite contains selenium, covalently bound to the largest subunit
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regulates the enzyme expression pattern, enzyme contains a catalytic selenocysteine
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contains selenium 2.9 mol, based of apparent molecular mass of 420000 Da
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isolated enzyme contains a reduced form of selenium, probably as selenocysteine
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as a consequence of Se deficiency increased phospholipase D activity and phosphatidic acid production contribute to enhanced enzyme activity, which results in an overall increase in platelet activating factor. The regulation of enzyme activity by Se may constitute an important control mechanism for the maintenance of levels of platelet activating factor in endothelial cells
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production of recombinant selenoproteins with internal selenocysteine residues in Escherichia coli. Introduction of a selenocysteine residue into the catalytic site of glutathione S-transferase is not sufficient to induce glutathione peroxidase activity in spite of a maintained glutathione-binding capacity
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selenoprotein
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3D Structure of Enzyme-Ligand-Complex (PDB) (80 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

KM Value (3 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for selenium

ChEBI
PubChem
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PubChem