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Ligand 7-amino-4-trifluoromethylcoumarin

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

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Show Natural Product (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.4.22.57

LEVD-7-amido-4-trifluoromethylcoumarin + H2O = LEVD + 7-amino-4-trifluoromethylcoumarin

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-

3.4.22.59

Ac-Val-Glu-Ile-Asp-7-amido-4-trifluoromethylcoumarin + H2O = Ac-Val-Glu-Ile-Asp + 7-amino-4-trifluoromethylcoumarin

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-

Product in Enzyme-catalyzed Reactions (86 results)

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Show Product (86 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.4.11.1

L-Ala-7-amido-4-trifluoro-methylcoumarin + H2O = L-Ala + 7-amino-4-trifluoromethylcoumarin

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-

3.4.11.1

L-Arg-7-amido-4-trifluoro-methylcoumarin + H2O = L-Arg + 7-amino-4-trifluoromethylcoumarin

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-

3.4.11.1

L-Leu-7-amido-4-trifluoro-methylcoumarin + H2O = L-Leu + 7-amino-4-trifluoromethylcoumarin

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3.4.11.1

Leu-4-trifluoroomethylcoumarin-7-amide + H2O = Leu + 7-amino-4-trifluoromethylcoumarin

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-

3.4.11.1

4 entries

3.4.13.9

Gly-Pro-4-trifluoromethylcoumarin-7-amide + H2O = Gly + Pro + 7-amino-4-trifluoromethylcoumarin

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-

3.4.14.2

Ala-Pro-amino-4-trifluoromethylcoumarin + H2O = Ala-Pro + amino-4-trifluoromethylcoumarin

651779, 649748

-

3.4.14.5

Ala-Pro-7-amido-4-trifluoromethyl coumarin + H2O = Ala-Pro + 7-amino-4-trifluoromethyl coumarin

653913

-

3.4.14.5

Gly-Pro-7-amido-4-trifluoromethyl coumarin + H2O = Gly-Pro + 7-amino-4-trifluoromethyl coumarin

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-

3.4.14.5

Ala-Pro-7-amido-4-trifluoromethylcoumarin + H2O = Ala-Pro + 7-amino-4-trifluoromethylcoumarin

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-

3.4.14.5

L-Ala-L-Pro-7-amido-4-trifluoromethylcoumarin + H2O = L-Ala-L-Pro + 7-amino-4-trifluoromethylcoumarin

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3.4.14.5

L-Pro-L-Ala-7-amido-4-trifluoromethylcoumarin + H2O = L-Pro-L-Ala + 7-amino-4-trifluoromethylcoumarin

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-

3.4.14.5

5 entries

3.4.21.35

D-Val-Leu-Arg-7-amido-4-trifluoromethylcoumarin + H2O = D-Val-Leu-Arg + 7-amino-4-trifluoromethylcoumarin

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3.4.21.59

Benzyloxycarbonyl-Gly-Arg 4-trifluoromethylcoumarin 7-amide + H2O = Benzyloxycarbonyl-Gly-Arg + 7-amino-4-trifluoromethylcoumarin

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-

3.4.21.59

Benzyloxycarbonyl-Lys-Arg 4-trifluoromethylcoumarin 7-amide + H2O = Benzyloxycarbonyl-Lys-Arg + 7-amino-4-trifluoromethylcoumarin

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3.4.21.59

2 entries

3.4.21.73

N-benzyloxycarbonyl-Gly-Gly-Arg-7-amido-4-trifluoromethylcoumarin + H2O = N-benzyloxycarbonyl-Gly-Gly-Arg + 7-amino-4-trifluoromethylcoumarin

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3.4.21.B12

D-Val-Leu-Arg-7-amido-4-trifluoromethyl coumarin + H2O = D-Val-Leu-Arg + 7-amino-4-trifluoromethyl coumarin

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3.4.21.B24

Boc-RERR-7-amido-4-trifluoromethyl coumarin + H2O = Boc-RERR + 7-amino-4-trifluoromethyl coumarin

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3.4.21.B28

acetyl-D-Ala-Pro-7-amido-4-trifluoromethylcoumarin + H2O = acetyl-D-Ala-Pro + 7-amino-4-trifluoromethylcoumarin

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3.4.21.B28

Ala-Pro-4-trifluoromethylcoumarin-7-amide + H2O = Ala-Pro + 7-amino-4-trifluoromethylcoumarin

651968, 653744

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3.4.21.B28

Ala-Pro-4-trifluoromethylcoumarin-7-amide + H2O = Ala-Pro-4 + 7-amino-4-trifluoromethylcoumarin

651537

-

3.4.21.B28

Ala-Pro-7-amido-4-trifluoromethylcoumarin + H2O = Ala-Pro + 7-amino-4-trifluoromethylcoumarin

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-

3.4.21.B28

Ala-Pro-7-amido-4-trifluoromethylcoumarin + H2O = Ala-Pro + 7-amino-4-trifluoromethylcoumarin + H2O

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3.4.21.B28

D-Ala-Pro-7-amido-4-trifluoromethylcoumarin + H2O = D-Ala-Pro + 7-amino-4-trifluoromethylcoumarin

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3.4.21.B28

Gly-Pro-4-trifluoromethylcoumarin-7-amide + H2O = Gly-Pro + 7-amino-4-trifluoromethylcoumarin

651537

-

3.4.21.B28

Gly-Pro-7-amido-4-trifluoromethylcoumarin + H2O = Gly-Pro + 7-amino-4-trifluoromethylcoumarin

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-

3.4.21.B28

Gly-Pro-7-amido-4-trifluoromethylcoumarin + H2O = Gly-Pro + 7-amino-4-trifluoromethylcoumarin + H2O

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-

3.4.21.B28

Ile-Pro-7-amido-4-trifluoromethylcoumarin + H2O = Ile-Pro + 7-amino-4-trifluoromethylcoumarin

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-

3.4.21.B28

L-Ala-Pro-7-amido-4-trifluoromethylcoumarin + H2O = L-Ala-Pro + 7-amino-4-trifluoromethylcoumarin

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3.4.21.B28

Lys-Ala-7-amido-4-trifluoromethylcoumarin + H2O = Lys-Ala + 7-amino-4-trifluoromethylcoumarin

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-

3.4.21.B28

Lys-Pro-4-trifluoromethylcoumarin-7-amide + H2O = Lys-Pro + 7-amino-4-trifluoromethylcoumarin

651968

-

3.4.21.B28

Phe-Pro-7-amido-4-trifluoromethylcoumarin + H2O = Phe-Pro + 7-amino-4-trifluoromethylcoumarin

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3.4.21.B28

14 entries

3.4.21.B6

benzyloxycarbonyl-Gly-Pro-Arg-7-amido-4-trifluoromethylcoumarin = benzyloxycarbonyl-Gly-Pro-Arg + 7-amino-4-trifluoromethylcoumarin

651845

-

3.4.22.1

Ac-Arg-Arg-7-amido-4-trifluoromethylcoumarin + H2O = Ac-Arg-Arg + 7-amino-4-trifluoromethylcoumarin

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3.4.22.1

Nalpha-benzyloxycarbonyl-L-Arg-L-Arg-7-amido-4-trifluoromethylcoumarin + H2O = Nalpha-benzyloxycarbonyl-L-Arg-L-Arg + 7-amino-4-trifluoromethylcoumarin

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3.4.22.15

benzyloxycarbonyl-L-Phe-L-Arg-7-amido-4-trifluoromethylcoumarin + H2O = benzyloxycarbonyl-L-Phe-L-Arg + 7-amino-4-trifluoromethylcoumarin

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3.4.22.15

N-acetyl-Phe-Arg-7-amido-4-trifluoromethylcoumarin + H2O = N-acetyl-Phe-Arg + 7-amino-4-trifluoromethylcoumarin

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3.4.22.1

2 entries

3.4.22.15

2 entries

3.4.22.16

Arg-7-amido-4-trifluoromethylcoumarin + H2O = Arg + 7-amino-4-trifluoromethylcoumarin

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3.4.22.29

acetyl-LSTT-7-amido-4-trifluoromethylcoumarin + H2O = acetyl-LSTT + 7-amino-4-trifluoromethylcoumarin

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3.4.22.35

Z-Arg-Arg-7-amido-4-trifluoromethylcoumarin + H2O = Z-Arg-Arg + 7-amino-4-trifluoromethylcoumarin

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3.4.22.36

N-acetyl-WEHD-7-amido-4-trifluoromethylcoumarin + H2O = N-acetyl-WEHD + 7-amino-4-trifluoromethylcoumarin

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3.4.22.41

N-acetyl-DEVD-7-amido-4-trifluoromethylcoumarin + H2O = N-acetyl-DEVD + 7-amino-4-trifluoromethylcoumarin

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3.4.22.52

N-benzyloxycarbonyl-L-Leu-L-Arg-7-amido-4-trifluoromethylcoumarin + H2O = N-benzyloxycarbonyl-L-Leu-L-Arg + 7-amino-4-trifluoromethylcoumarin

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3.4.22.53

N-acetyl-LLY-7-amido-4-trifluoromethylcoumarin + H2O = N-acetyl-LLY + 7-amino-4-trifluoromethylcoumarin

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3.4.22.55

Ac-DEVD-7-amino-4-trifluoromethyl coumarin + H2O = 7-amino-4-trifluoromethyl coumarin + Ac-DEVD

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3.4.22.55

Z-VDVAD-7-amino-4-trifluoromethyl coumarin + H2O = 7-amino-4-trifluoromethyl coumarin + Z-VDVAD

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3.4.22.55

Val-Asp-Val-Ala-Asp-7-amido-4-trifluoromethylcoumarin + H2O = Val-Asp-Val-Ala-Asp + 7-amino-4-trifluoromethylcoumarin

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3.4.22.55

DEVD-AFC + H2O = DEVD + AFC

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3.4.22.55

VDVADAFC + H2O = VDVAD + AFC

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3.4.22.56

acetyl-Asp-Glu-Val-Asp-7-amido-4-trifluoromethylcoumarin + H2O = acetyl-Asp-Glu-Val-Asp + 7-amino-4-trifluoromethylcoumarin

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3.4.22.56

DEVD-7-amido-4-trifluoromethylcoumarin + H2O = DEVD + 7-amino-4-trifluoromethylcoumarin

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3.4.22.56

N-acetyl-Asp-Glu-Val-Asp-7-amido-4-trifluoromethylcoumarin + H2O = N-acetyl-Asp-Glu-Val-Asp + 7-amino-4-trifluoromethylcoumarin

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3.4.22.56

N-acetyl-DEVD-4-trifluoromethylcoumarin 7-amide + H2O = N-acetyl-DEVD + 7-amino-4-trifluoromethylcoumarin

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3.4.22.56

DEVD-amido-4-trifluoromethylcoumarin + H2O = DEVD + amino-4-trifluoromethylcoumarin

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3.4.22.57

Ac-Leu-Glu-Val-Asp-7-amido-4-trifluoro methylcoumarin + H2O = 7-amino-4-trifluoromethylcoumarin + Ac-Leu-Glu-Val-Asp

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3.4.22.57

LEVD-7-amido-4-trifluoromethylcoumarin + H2O = LEVD + 7-amino-4-trifluoromethylcoumarin

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3.4.22.59

Ac-Val-Glu-Ile-Asp-7-amido-4-trifluoromethylcoumarin + H2O = Ac-Val-Glu-Ile-Asp + 7-amino-4-trifluoromethylcoumarin

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3.4.22.59

Ac-VEID-4-trifluoromethylcoumarin 7-amide + H2O = Ac-VEID + 7-amino-4-trifluoromethylcoumarin

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3.4.22.59

IETD-7-amido-4-trifluoromethylcoumarin + H2O = IETD + 7-amino-4-trifluoromethylcoumarin

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3.4.22.59

N-acetyl-Asp-Glu-Val-Asp-7-amido-4-trifluoromethylcoumarin + H2O = N-acetyl-Asp-Glu-Val-Asp + 7-amino-4-trifluoromethylcoumarin

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3.4.22.59

N-acetyl-Val-Glu-Ile-Asp-7-amido-4-trifluoromethylcoumarin + H2O = N-acetyl-Val-Glu-Ile-Asp + 7-amino-4-trifluoromethylcoumarin

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3.4.22.59

Val-Glu-Ile-Asp-7-amido-4-trifluoromethylcoumarin + H2O = Val-Glu-Ile-Asp + 7-amino-4-trifluoromethylcoumarin

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3.4.22.59

VEID-7-amido-4-trifluoromethylcoumarin + H2O = VEID + 7-amino-4-trifluoromethylcoumarin

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3.4.22.60

N-acetyl-DEVD-7-amido-4-trifluoromethylcoumarin + H2O = acetyl-DEVD + 7-amino-4-trifluoromethylcoumarin

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3.4.22.60

N-acetyl-PEVD-7-amido-4-trifluoromethylcoumarin + H2O = acetyl-PEVD + 7-amino-4-trifluoromethylcoumarin

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3.4.22.61

Ac-Leu-Glu-Thr-Asp-7-amido-4-trifluoromethylcoumarin + H2O = Ac-Leu-Glu-Thr-Asp + 7-amino-4-trifluoromethylcoumarin

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3.4.22.61

acetyl-Ile-Glu(OMe)-Thr-Asp(OMe)-7-amido-4-trifluoromethylcoumarin + H2O = acetyl-Ile-Glu(OMe)-Thr-Asp(OMe) + 7-amino-4-trifluoromethylcoumarin

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3.4.22.61

benzyloxycarbonyl-IETD-7-amido-4-trifluoromethylcoumarin + H2O = benzyloxycarbonyl-IETD + 7-amino-4-trifluoromethylcoumarin

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3.4.22.61

IETD-7-amido-4-trifluoromethylcoumarin + H2O = IETD + 7-amino-4-trifluoromethylcoumarin

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3.4.22.61

N-acetyl-IETD-4-trifluoromethylcoumarin 7-amide + H2O = N-acetyl-IETD + 7-amino-4-trifluoromethylcoumarin

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3.4.22.62

acetyl-LEHD-7-amido-4-trifluoromethyl coumarin + H2O = acetyl-LEHD + 7-amino-4-trifluoromethyl coumarin

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3.4.22.62

acetyl-DEVD-7-amido-4-trifluoromethylcoumarin + H2O = acetyl-DEVD + 7-amino-4-trifluoromethylcoumarin

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3.4.22.62

acetyl-LEHD-7-amido-4-trifluoromethylcoumarin + H2O = acetyl-LEHD + 7-amino-4-trifluoromethylcoumarin

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3.4.22.62

IETD-7-amido-4-trifluoromethylcoumarin + H2O = IETD + 7-amino-4-trifluoromethylcoumarin

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3.4.22.62

N-acetyl-LEHD-4-trifluoromethylcoumarin 7-amide + H2O = N-acetyl-LEHD + 7-amino-4-trifluoromethylcoumarin

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3.4.22.63

Ac-IETD-4-trifluoromethylcoumarin-7-amide + H2O = Ac-IETD + 7-amino-4-trifluoromethylcoumarin

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3.4.22.63

acetyl-Ala-Glu-Val-Asp-4-trifluoromethylcoumarin-7-amide + H2O = acetyl-Ala-Glu-Val-Asp + 7-amino-4-trifluoromethylcoumarin

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3.4.22.B49

acetyl-FR-7-amido-4-trifluoromethyl coumarin + H2O = acetyl-FR + 7-amino-4-trifluoromethyl coumarin

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3.4.22.B49

benzyloxycarbonyl-Phe-Arg-7-amido-4-trifluoromethylcoumarin + H2O = benzyloxycarbonyl-Phe-Arg + 7-amino-4-trifluoromethylcoumarin

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3.4.22.B49

N-benzyloxycarbonyl-FR-7-amido-4-trifluoromethylcoumarin + H2O = N-benzyloxycarbonyl-FR + 7-amino-4-trifluoromethylcoumarin

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3.4.22.B50

ubiquitin-7-amido-4-trifluoro-methyl-coumarin + H2O = ubiquitin + 7-amino-4-trifluoro-methyl-coumarin

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3.4.22.B50

ubiquitin-7-amido-4-trifluoromethylcoumarin + H2O = ubiquitin + 7-amino-4-trifluoromethylcoumarin

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3.4.22.55

5 entries

3.4.22.56

5 entries

3.4.22.57

2 entries

3.4.22.59

7 entries

3.4.22.60

2 entries

3.4.22.61

5 entries

3.4.22.62

5 entries

3.4.22.63

2 entries

3.4.22.B49

3 entries

3.4.22.B50

2 entries

3.4.22.B71

acetyl-QTGG-7-amino-4-trifluoromethylcoumarin + H2O = acetyl-QTGG + 7-amino-4-trifluoromethylcoumarin

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3.4.22.B74

acetyl-LRGG-7-amido-4-trifluoromethylcoumarin + H2O = acetyl-LRGG + 7-amino-4-trifluoromethylcoumarin

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3.4.22.B74

acetyl-QTGG-7-amido-4-trifluoromethylcoumarin + H2O = acetyl-QTGG + 7-amino-4-trifluoromethylcoumarin

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3.4.22.B75

acetyl-LRGG-7-amido-4-trifluoromethylcoumarin + H2O = acetyl-LRGG + 7-amino-4-trifluoromethylcoumarin

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3.4.22.B75

acetyl-QTGG-7-amido-4-trifluoromethylcoumarin + H2O = acetyl-QTGG + 7-amino-4-trifluoromethylcoumarin

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3.4.22.B74

2 entries

3.4.22.B75

2 entries

Enzyme Kinetic Parameters

References & Links

Literature References (7)

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Show Reference (7 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

649748

12529175

Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII

2003

Leiting, B.; Pryor, K.D.; Wu, J.K.; Marsilio, F.; Patel, R.A.; Craik, C.S.; Ellman, J.A.; Cummings, R.T.; Thornberry, N.A.

Biochem. J.

371

525-532

651537

7519584

Fibroblast activation protein: purification, epitope mapping and induction by growth factors

1994

Rettig, W.J.; Su, S.L.; Fortunato, S.R.; Scanlan, M.J.; Raj, B.K.; Garin-Chesa, P.; Healey, J.H.; Old, L.J.

Int. J. Cancer

58

385-392

651779

11173530

Purification, molecular cloning, and immunohistochemical localization of dipeptidyl peptidase II from the rat kidney and its identity with quiescent cell proline dipeptidase

2001

Araki, H.; Li, Y.; Yamamoto, Y.; Haneda, M.; Nishi, K.; Kikkawa, R.; Ohkubo, I.

J. Biochem.

129

279-288

651845

8034638

Prostasin is a novel human serine proteinase from seminal fluid. Purification, tissue distribution, and localization in prostate gland

1994

Yu, J.X.; Chao, L.; Chao, J.

J. Biol. Chem.

269

18843-18848

651968

10593948

Fibroblast activation protein, a dual specificity serine protease expressed in reactive human tumor stromal fibroblasts

1999

Park, J.E.; Lenter, M.C.; Zimmermann, R.N.; Garin-Chesa, P.; Old, L.J.; Rettig, W.J.

J. Biol. Chem.

274

36505-36512

653744

11858723

Expression, purification, and kinetic characterization of full-length human fibroblast activation protein

2002

Sun, S.; Albright, C.F.; Fish, B.H.; George, H.J.; Selling, B.H.; Hollis, G.F.; Wynn, R.

Protein Expr. Purif.

24

274-281

653913

12906826

Structural basis of proline-specific exopeptidase activity as observed in human dipeptidyl peptidase-IV

2003

Thoma, R.; Loffler, B.; Stihle, M.; Huber, W.; Ruf, A.; Hennig, M.

Structure

11

947-959

Links to other databases for 7-amino-4-trifluoromethylcoumarin

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Show Links (1 entry)

ChEBI

PubChem

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