Ligand 1D-myo-inositol 1,4,5-trisphosphate

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Basic Ligand Information

Molecular Structure
Picture of 1D-myo-inositol 1,4,5-trisphosphate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H15O15P3
1D-myo-inositol 1,4,5-trisphosphate
MMWCIQZXVOZEGG-HOZKJCLWSA-N
Synonyms:
1D-myo-inositol 1,4,5-triphosphate, D-myo-inositol-1,4,5-trisphosphate, D-myo-inositol 1,4,5-triphosphate, D-myo-inositol 1,4,5-trisphosphate, inositol (1,4,5)-triphosphate, inositol (1,4,5)-trisphosphate, inositol(3,5,6)-trisphosphate, inositol (3,5,6)-trisphosphate, inositol-1,4,5-trisphosphate, inositol 1,4,5-triphosphate, Inositol 1,4,5-trisphosphate, inositol trisphosphate, InsP3, myo-inositol-1,4,5-trisphosphate, myo-inositol 1,4,5-triphosphate, myo-inositol 1,4,5-trisphosphate, myoinositol 1,4,5-trisphosphate
Pathway Source
Pathways
KEGG
Adrenergic signaling in cardiomyocytes, African trypanosomiasis, AGE-RAGE signaling pathway in diabetic complications, Aldosterone synthesis and secretion, Alzheimer disease more

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

In Vivo Product in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = D-myo-inositol 1,4,5-trisphosphate + phosphate
show the reaction diagram
-
phosphatidylinositol-bisphosphate + H2O = inositol 1,4,5-trisphosphate + 1,2-diacylglycerol
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (22 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + myo-inositol 1,4,5-trisphosphate = ADP + myo-inositol-1,3,4,5-tetrakisphosphate
show the reaction diagram
-
ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
show the reaction diagram
-
inositol 1,4,5-triphosphate + H2O = ?
show the reaction diagram
-
inositol 1,4,5-trisphosphate + H2O = ? + phosphate
show the reaction diagram
-
D-myo-inositol-1,4,5-trisphosphate + H2O = ?
show the reaction diagram
-
inositol 1,4,5-trisphosphate + H2O = inositol 1,5-bisphosphate + phosphate
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = D-myo-inositol 1,4,5-trisphosphate + phosphate
show the reaction diagram
-
phosphatidylinositol-bisphosphate + H2O = inositol 1,4,5-trisphosphate + 1,2-diacylglycerol
show the reaction diagram
-

Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activates, maximal 30.6fold activation
-

Inhibitor in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
IC50: 0.1 mM
-
IC50 for ATP synthase activity is 0.253 mM
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
340
-
37°C

KM Value (58 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.00011
-
pH 7.2, 37°C
0.00055
-
about, cosubstrate: ATP

Ki Value (3 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.048
-
pH 7.2, 37°C
0.002
-
-
0.002
-
pH 7.4, 37°C

IC50 Value (2 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.003
-
strong inhibition, purified recombinant enzyme, IC50 value is 0.003 mM in absence of Ca2+
0.1
-
IC50: 0.1 mM

References & Links

Links to other databases for 1D-myo-inositol 1,4,5-trisphosphate

ChEBI
PubChem
-
PubChem