We're sorry, but BRENDA doesn't work properly without JavaScript. Please make sure you have JavaScript enabled in your browser settings.
Ligand N-acetylmuramic acid 1-phosphate Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C1 1 H2 0 NO1 1 P
N-acetylmuramic acid 1-phosphate
DTSXRQWOCZUNPL-YVNCZSHWSA-N
N-acetyl-alpha-D-muramate 1-phosphate
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
UDP + N-acetyl-alpha-D-muramate 1-phosphate = UDP-N-acetyl-alpha-D-muramate + phosphate
-
In Vivo Product in Enzyme-catalyzed Reactions (1 result)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + N-acetyl-D-muramate = ADP + N-acetyl-alpha-D-muramate 1-phosphate
-
Substrate in Enzyme-catalyzed Reactions (2 results)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
UDP + N-acetyl-alpha-D-muramate 1-phosphate = UDP-N-acetyl-alpha-D-muramate + phosphate
-
UTP + N-acetyl-alpha-D-muramate 1-phosphate = UDP-N-acetyl-alpha-D-muramate + diphosphate
-
Product in Enzyme-catalyzed Reactions (1 result)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + N-acetyl-D-muramate = ADP + N-acetyl-alpha-D-muramate 1-phosphate
-
Enzyme Kinetic Parameters
References & Links Literature References (4)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Crystal structure of the N-acetylmuramic acid alpha-1-phosphate (MurNAc-alpha1-P) uridylyltransferase MurU, a minimal sugar nucleotidyltransferase and potential drug target enzyme in Gram-negative pathogens
2015
Renner-Schneck, M.; Hinderberger, I.; Gisin, J.; Exner, T.; Mayer, C.; Stehle, T.
J. Biol. Chem.
290
10804-10813
A cell wall recycling shortcut that bypasses peptidoglycan de novo biosynthesis
2013
Gisin, J.; Schneider, A.; Naegele, B.; Borisova, M.; Mayer, C.
Nat. Chem. Biol.
9
491-493
Synthesis of functionalized N-acetyl muramic acids to probe bacterial cell wall recycling and biosynthesis
2018
DeMeester, K.E.; Liang, H.; Jensen, M.R.; Jones, Z.S.; D'Ambrosio, E.A.; Scinto, S.L.; Zhou, J.; Grimes, C.L.
J. Am. Chem. Soc.
140
9458-9465
Utility of bacterial peptidoglycan recycling enzymes in the chemoenzymatic synthesis of valuable UDP sugar substrates
2020
Ukaegbu, O.I.; DeMeester, K.E.; Liang, H.; Brown, A.R.; Jones, Z.S.; Grimes, C.L.
Methods Enzymol.
638
1-26
Links to other databases for N-acetylmuramic acid 1-phosphate