Ligand isolithocholic acid

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Basic Ligand Information

Molecular Structure
Picture of isolithocholic acid (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C24H40O3
isolithocholic acid
SMEROWZSTRWXGI-WFVDQZAMSA-N
Synonyms:
3beta-hydroxy-5beta-cholan-24-oic acid, 3beta-hydroxy-5beta-cholanoate, 3beta-hydroxy-5beta-cholanoic acid, 5beta-cholanic acid-3beta-ol, isolithocholate

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3beta-hydroxy-5beta-cholanoate + NAD+ = 3-oxo-5beta-cholanoate + NADH
show the reaction diagram
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isolithocholic acid + NADP+ = dehydrolithocholic acid + NADPH
show the reaction diagram
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isolithocholic acid + NADP+ = ? + NADPH + H+
show the reaction diagram
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3beta-hydroxy-5beta-cholan-24-oic acid + NAD+ = 3-oxo-5beta-cholan-24-oic acid + NADH + H+
show the reaction diagram
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3'-phosphoadenylyl sulfate + isolithocholic acid = adenosine 3',5'-bisphosphate + isolithocholate sulfate
show the reaction diagram
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3'-phosphoadenylyl 5'-phosphosulfate + 3beta-hydroxy-5beta-cholanoic acid = adenosine 3',5'-bisphosphate + 3beta-hydroxy-5beta-cholanoic acid 3-sulfate
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dehydrolithocholic acid + NADPH = isolithocholic acid + NADP+
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (2 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (3 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.00024
-
pH 6.5, 37°C, 5 mM MgCl2

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.026
-
pH 6.5, 37°C

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.000027
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C

References & Links

Links to other databases for isolithocholic acid

ChEBI
PubChem
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PubChem