print visible entries

print all entries

Ligand D-4-hydroxyphenylglycine

Basic Ligand Information

Molecular Structure

close all tables

open all tables

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

top print hide

Show Natural Substrate (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.4.3.19

D-4-hydroxyphenylglycine + H2O + O2 = ?

725913

-

2.6.1.72

D-4-hydroxyphenylglycine + 2-oxoglutarate = 4-hydroxyphenylglyoxylate + L-glutamate

636991, 636992, 759129

-

In Vivo Product in Enzyme-catalyzed Reactions (3 results)

top print hide

Show Natural Product (3 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.6.1.72

4-hydroxyphenylglyoxylate + L-glutamate = D-4-hydroxyphenylglycine + 2-oxoglutarate

-

-

3.5.1.77

N-carbamoyl-D-4-hydroxyphenylglycine + H2O = D-4-hydroxyphenylglycine + NH3 + CO2

-

-

3.5.1.77

N-carbamoyl-D-p-hydroxyphenylglycine + H2O = D-p-hydroxyphenylglycine + NH3 + CO2

-

-

3.5.1.77

2 entries

Substrate in Enzyme-catalyzed Reactions (3 results)

top print hide

Show Substrate (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.4.3.19

D-4-hydroxyphenylglycine + H2O + O2 = ?

725913

-

1.4.3.3

D-4-hydroxy-phenylglycine + H2O + O2 = (4-hydroxyphenyl)acetic acid + NH3 + H2O2

688440

-

2.6.1.72

D-4-hydroxyphenylglycine + 2-oxoglutarate = 4-hydroxyphenylglyoxylate + L-glutamate

636992, 636991, 759129

-

Product in Enzyme-catalyzed Reactions (8 results)

top print hide

Show Product (8 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.6.1.72

4-hydroxyphenylglyoxylate + L-glutamate = D-4-hydroxyphenylglycine + 2-oxoglutarate

-

-

3.1.1.43

D-4-hydroxyphenylglycine methyl ester + H2O = D-4-hydroxyphenylglycine + methanol

-

-

3.5.1.11

(R) -2-(4-hydroxyphenyl)glycine amide + H2O = (R) -2-(4-hydroxyphenyl)glycine + hydroxylamine

653284

-

3.5.1.11

amoxillin + H2O = D-4-hydroxyphenylglycine + 6-aminopenicillanic acid

-

-

3.5.1.77

N-carbamoyl-D-4-hydroxyphenylglycine + H2O = D-4-hydroxyphenylglycine + NH3 + CO2

-

-

3.5.1.77

N-carbamoyl-D-hydroxyphenylglycine + H2O = D-hydroxyphenylglycine + NH3 + CO2

-

-

3.5.1.77

N-carbamoyl-D-p-hydroxyphenylglycine + H2O = D-p-hydroxyphenylglycine + NH3 + CO2

-

-

3.5.1.11

2 entries

3.5.1.77

3 entries

3.5.2.2

DL-5-p-hydroxyphenylhydantoin + H2O = D-p-hydroxyphenylglycine

-

-

3D Structure of Enzyme-Ligand-Complex (PDB) (15 results)

top print hide

Show 3D Structure of Enzyme-Ligand-Complex (PDB) (15 entries)

EC NUMBER

ENZYME 3D STRUCTURE

3.2.1.17

3RUN, 3D-view

3.2.1.17

4PJZ, 3D-view

3.2.1.17

4PK0, 3D-view

3.2.1.17

3RUN, 3D-view

3.2.1.17

4PJZ, 3D-view

3.2.1.17

4PK0, 3D-view

3.2.1.17

3RUN, 3D-view

3.2.1.17

4PJZ, 3D-view

3.2.1.17

4PK0, 3D-view

3.2.1.17

3RUN, 3D-view

3.2.1.17

4PJZ, 3D-view

3.2.1.17

4PK0, 3D-view

3.2.1.17

3RUN, 3D-view

3.2.1.17

4PJZ, 3D-view

3.2.1.17

4PK0, 3D-view

3.2.1.17

15 entries

Enzyme Kinetic Parameters

K_M Value (2 results)

top print hide

Show KM Value (2 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.4.3.3

1.6

-

mutant enzyme M213G, in 75 mM sodium diphosphate buffer, pH 8.5 at 25°C

688440

1.4.3.3

2.1

-

wild type enzyme, in 75 mM sodium diphosphate buffer, pH 8.5 at 25°C

688440

1.4.3.3

2 entries

References & Links

Literature References (6)

top print hide

Show Reference (6 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

636991

-

DL-4-Hydroxyphenylglycine catabolism in Pseudomonas putida MW27

1988

Van den Tweel, W.J.J.; Widjojoatmodjo, M.N.; de Bont, J.A.M.

Arch. Microbiol.

150

471-476

636992

-

The involvement of an enantioselctive transaminase in the metabolism of D-3- and D-4-hydroxyphenylglycine in Pseudomonas putida LW-4

1988

Van den Tweel, W.J.J.; Smits, J.P.; Ogg, R.L.H.P.; de Bont, J.A.M.

Appl. Microbiol. Biotechnol.

29

224-230

653284

-

Comparative study of substrate- and stereospecificity of penicillin G amidases from different sources and hybrid isoenzymes

2000

Galunsky, B.; Lummer, K.; Kasche, V.

Monatsh. Chem.

131

623-632

688440

-

Activity of yeast D-amino acid oxidase on aromatic unnatural amino acids

2008

Caligiuri, A.; DArrigo, P.; Rosini, E.; Pedrocchi-Fantoni, G.; Tessaro, D.; Molla, G.; Servi, S.; Pollegioni, L.

J. Mol. Catal. B

50

93-98

725913

23873697

Identification in Marinomonas mediterranea of a novel quinoprotein with glycine oxidase activity

2013

Campillo-Brocal, J.C.; Lucas-Elio, P.; Sanchez-Amat, A.

Microbiologyopen

2

684-694

759129

29887020

Fast, affordable and eco-friendly enzyme kinetic method for the assay of alpha-ketoglutaric acid in medical product and sports supplements

2018

Rojanarata, T.; Laiwattanapaisal, W.; Ngawhirunpat, T.; Opanasopit, P.; Worrawethanakul, K.; Chantadee, T.; Fuangwattana, T.

Enzyme Microb. Technol.

116

72-76

Links to other databases for D-4-hydroxyphenylglycine

top print hide

Show Links (1 entry)