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Ligand cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Natural Substrate (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.3.1.64

cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate + NAD+ = 4,5-dihydroxyphthalate + NADH + H+

133772

-

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

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Show Natural Product (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.12.7

phthalate + NADH + H+ + O2 = cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate + NAD+

0

-

Substrate in Enzyme-catalyzed Reactions (1 result)

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EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.3.1.64

cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate + NAD+ = 4,5-dihydroxyphthalate + NADH + H+

133772

-

Product in Enzyme-catalyzed Reactions (3 results)

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Show Product (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.12.7

phthalate + NADH + H+ + O2 = cis-4,5-dihydro-4,5-dihydroxyphthalate + NAD+

0

-

1.14.12.7

phthalate + NADH + H+ + O2 = cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate + NAD+

0

-

1.14.12.7

phthalate + NADH + O2 = cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate + NAD+ + H2O

439047, 439048, 439049, 439051, 439052, 439053, 0, 133772

-

1.14.12.7

3 entries

Enzyme Kinetic Parameters

References & Links

Literature References (7)

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Show Reference (7 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

133772

3805038

Purification and characterization of phthalate oxygenase and phthalate oxygenase reductase from Pseudomonas cepacia

1987

Batie, C.J.; LaHaie, E.; Ballou, D.P.

J. Biol. Chem.

262

1510-1518

439047

2280719

Phthalate dioxygenase

1990

Batie, C.J.; Ballou, D.P.

Methods Enzymol.

188

61-70

439048

2982852

Evidence for N coordination to Fe in the [2Fe-2S] clusters of Thermus Rieske protein and phthalate dioxygenase from Pseudomonas

1985

Cline, J.F.; Hoffman, B.M.; Mims, W.B.; LaHaie, E.; Ballou, D.P.; Fee, J.A.

J. Biol. Chem.

260

3251-3254

439049

2765515

Electron-nuclear double resonance spectroscopy of 15N-enriched phthalate dioxygenase from Pseudomonas cepacia proves that two histidines are coordinated to the [2Fe-2S] Rieske-type clusters

1989

Gurbiel, R.J.; Batie, C.J.; Sivaraja, M.; True, A.E.; Fee, J.A.; Hoffman, B.M.; Ballou, D.P.

Biochemistry

28

4861-4871

439051

9383387

Magnetic circular dichroism studies of exogenous ligand and substrate binding to the non-heme ferrous active site in phthalate dioxygenase

1994

Pavel, E.G.; Martins, L.J.; Ellis, W.R., Jr.; Solomon, E.I.

Chem. Biol.

1

173-183

439052

7683910

Magnetic circular dichroism studies on the mononuclear ferrous active site of phthalate dioxygenase from Pseudomonas cepacia show a change of ligation state on substrate binding

1993

Gassner, G.T.; Ballou, D.P.; Landrum, G.A.; Whittaker, J.W.

Biochemistry

32

4820-4825

439053

2819064

X-ray absoprtion spectroscopie of the [2Fe-2S] Rieske cluster in Pseudomonas cepacia phthalate dioxygenase. Determination of core dimensions and iron ligation

1989

Tsang, H.T.; Batie, C.J.; Ballou, D.P.; Penner-Hahn, J.E.

Biochemistry

28

7233-7240

Links to other databases for cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate

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ChEBI

PubChem