Ligand Chloroacetophenone

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Basic Ligand Information

Molecular Structure
Picture of Chloroacetophenone (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C8H7ClO
Chloroacetophenone
IMACFCSSMIZSPP-UHFFFAOYSA-N
Synonyms:
1-chloroacetophenone, 2-chloro-1-phenylethan-1-one, 2-chloroacetophenone, alpha-chloroacetophenone, omega-chloroacetophenon, omega-chloroacetophenone

Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-chloro-1-phenylethanol + NAD(P)+ = 2-chloro-1-phenylethan-1-one + NAD(P)H + H+
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-chloroacetophenone + NADH + H+ = 1-(2-chlorophenyl)ethanol + NAD+
show the reaction diagram
-
alpha-chloroacetophenone + NADPH = ? + NADP+
show the reaction diagram
-
2-chloro-1-phenylethan-1-one + NADH + H+ = 2-chloro-1-phenylethan-1-ol + NAD+
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-chloro-1-phenylethanol + NAD(P)+ = 2-chloro-1-phenylethan-1-one + NAD(P)H + H+
show the reaction diagram
-
-

Inhibitor in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
strong inhibition
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (4 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (5 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
2.71
-
with 4 mM NADPH, in 0.1 M sodium phosphate buffer, pH 7.0

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.0018
-
pH not specified in the publication, 37°C

References & Links

Links to other databases for Chloroacetophenone

ChEBI
PubChem
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PubChem