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Ligand alpha-D-glucuronic acid 1-phosphate

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

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Show Natural Substrate (3 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.7.44

UTP + 1-phospho-alpha-D-glucuronate = diphosphate + UDP-alpha-D-glucuronate

760379

-

2.7.7.64

UTP + alpha-D-glucuronate 1-phosphate = diphosphate + UDP-alpha-D-glucuronate

760379, 761567

-

2.7.7.64

UTP + alpha-D-glucuronate 1-phosphate = diphosphate + UDP-D-glucuronate

721524

-

2.7.7.64

2 entries

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

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Show Natural Product (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.1.43

ATP + D-glucuronate = ADP + 1-phospho-alpha-D-glucuronate

0

-

Substrate in Enzyme-catalyzed Reactions (5 results)

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Show Substrate (5 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.1.33

alpha-D-glucuronate 1-phosphate + (alginate)n = phosphate + ?

489052

-

2.7.7.44

UTP + 1-phospho-alpha-D-glucuronate = diphosphate + UDP-alpha-D-glucuronate

670505, 760379

-

2.7.7.64

UTP + alpha-D-glucuronate 1-phosphate = diphosphate + UDP-alpha-D-glucuronate

760379, 761567

-

2.7.7.64

UTP + alpha-D-glucuronate 1-phosphate = diphosphate + UDP-D-glucuronate

721524

-

2.7.7.64

2 entries

3.1.3.23

alpha-D-glucuronic acid 1-phosphate + H2O = alpha-D-glucuronic acid + phosphate

94723, 94726, 94722

-

Product in Enzyme-catalyzed Reactions (1 result)

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Show Product (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.1.43

ATP + D-glucuronate = ADP + 1-phospho-alpha-D-glucuronate

0

-

Inhibitor in Enzyme-catalyzed Reactions (1 result)

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Show Inhibitors (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.4.1.231

-

644899

-

Enzyme Kinetic Parameters

K_M Value (1 result)

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Show KM Value (1 entry)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.7.7.44

0.14

-

-

670505

K_i Value (1 result)

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Show KI Value (1 entry)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.4.1.231

13.4

-

30°C, pH 6.6

644899

References & Links

Literature References (9)

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Show Reference (9 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

94722

4290224

Sugar phosphate phosphohydrolase. I. Substrate specificity, intracellular localization, and purification from Neisseria meningitidis

1967

Lee, Y.P.; Sowokinos, J.R.; Erwin, M.J.

J. Biol. Chem.

242

2264-2271

94723

-

Molecular weight and some physicochemical and catalytic properties of sugar phosphate phosphohydrolase from Escherichia coli and Neisseria meningitidis

1975

Lee, Y.P.; Lee, A.T.; Choy, F.Y.M.; Sowokinos, J.R.

J. Biol. Chem.

250

3729-3737

94726

6322944

Survey, purification, and properties of sugar phosphate phosphohydrolase among microorganisms

1983

Choy, F.Y.M.; Lee, Y.P.

Can. J. Biochem. Cell Biol.

61

1292-1303

489052

5954796

Pathway of alginic acid synthesis in the marine brown alga, Fucus gardneri Silva

1966

Lin, T.Y.; Hassid, W.Z.

J. Biol. Chem.

241

5284-5297

644899

11931662

Substrate-binding recognition and specificity of trehalose phosphorylase from Schizophyllum commune examined in steady-state kinetic studies with deoxy and deoxyfluoro substrate analogues and inhibitors

2002

Eis, C.; Nidetzky, B.

Biochem. J.

363

335-340

670505

100107392

Biosynthesis of UDP-glucuronic acid in developing soybean embryos: Possible role of UDP-sugar pyrophosphorylase

2006

Litterer, L.A.; Plaisance, K.L.; Schnurr, J.A.; Storey, K.K.; Jung, H.J.G.; Gronwald, J.W.; Somers, D.A.

Physiol. Plant.

128

200-211

721524

20482518

Identification of a novel UDP-sugar pyrophosphorylase with a broad substrate specificity in Trypanosoma cruzi

2010

Yang, T.; Bar-Peled, M.

Biochem. J.

429

533-543

760379

-

Production of Arabidopsis thaliana UDP-sugar pyrophosphorylase by Pichia pastoris and its application in efficient UDP-Glucose and UDP-glucuronic acid synthesis

2019

Zang, L.; Du, R.; Zang, H.; Wang, F.; Sheng, J.

Appl. Biochem. Microbiol.

55

631-638

761567

28347767

Characterization of a new UDP-sugar pyrophosphorylase from Hordeum vulgare (barley)

2017

Wahl, C.; Spiertz, M.; Elling, L.

J. Biotechnol.

258

51-55

Links to other databases for alpha-D-glucuronic acid 1-phosphate

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Show Links (1 entry)

ChEBI

PubChem