Ligand Aminooxyacetate

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Basic Ligand Information

Molecular Structure
Picture of Aminooxyacetate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C2H5NO3
Aminooxyacetate
NQRKYASMKDDGHT-UHFFFAOYSA-M
Synonyms:
(aminooxy)acetic acid, 2-aminooxyacetate, 2-aminooxyacetic acid, Amino-oxyacetate, amino-oxyacetic acid, aminooxyacetic acid, aminooxy acetic acid, Aminoxyacetate, aminoxy acetate, aminoxyacetic acid, carboxylmethoxyamine, carboxymethoxylamine

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + gamma-Glu-L-Cys + aminooxyacetate = ADP + phosphate + gamma-Glu-Cys-aminoxyacetate
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (112 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive to glycolate and glyoxylate
-
5 mM, weak inhibition of isozymes 1-3
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strong
-
hydrolase reaction
-
soluble fraction
-
strong inhibition
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complete inhibition by a mixture of hydroxylamine, (aminooxy)acetic acid, and gabaculine as inhibitors specific for pyridoxal 5'-phosphate-dependent enzymes
-
1 mM, 100% inhibition
-
strong
-
inhibitory in whole cells
-
1 mM, complete inhibition of the three isoenzymes
-
0.002 mM, 50% inhibition
-
0.005-1 mM, enzymatic activity is progressively inhibited as the aminooxyacetic acid concentration is increased
-
0.5 mM, 2% residual activity; 0.5 mM, complete inhibition
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complete inhibition at 0.002 mM
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3D Structure of Enzyme-Ligand-Complex (PDB) (3 results)

Enzyme Kinetic Parameters

Ki Value (16 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
1.2
-
-
0.014
-
-
0.00012
-
-
0.0033
-
value bases on non-linear regression

IC50 Value (6 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.8
-
pH 8.0, 42°C
0.0011
-
pH 8.2, 37°C
0.0305
-
at 10 microM, IC50 value is 0.0305 mM

References & Links

Links to other databases for Aminooxyacetate

ChEBI
PubChem
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PubChem