Ligand 2-isopropylmaleate
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Basic Ligand Information
Molecular Structure
C7H10O4
2-isopropylmaleate
NJMGRJLQRLFQQX-HYXAFXHYSA-N
dimethyl-citraconate, Dimethyl citraconate, isopropylmaleate
Show all BRENDA pathways known for 2-isopropylmaleate
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)
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2-isopropylmaleate + H2O = ?
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)
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(2R,3S)-3-isopropylmalate = 2-isopropylmaleate + H2O
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Substrate in Enzyme-catalyzed Reactions (3 results)
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S-adenosyl-L-methionine + isopropylmaleate = S-adenosyl-L-homocysteine + ?
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2-isopropylmaleate + H2O = 3-isopropylmalate
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2-isopropylmaleate + H2O = ?
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Product in Enzyme-catalyzed Reactions (2 results)
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(2R,3S)-3-isopropylmalate = 2-isopropylmaleate + H2O
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3-isopropylmalate = 2-isopropylmaleate + H2O
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Enzyme Kinetic Parameters
KM Value (1 result)
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References & Links
Literature References (6)
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Isopropylmalate isomerase (Neurospora)
1970
Gross, S.R.
Methods Enzymol.
17A
786-790
Yeast alpha-isopropylmalate isomerase. Factors affecting enzyme stability and enzyme activity
1976
Bigelis, R.; Umbarger, H.E.
J. Biol. Chem.
251
3545-3552
Structural features of normal and complemented forms of the Neurospora isopropylmalate isomerase
1978
Reichenbecher Jr, V.E.; Gross, S.R.
J. Bacteriol.
133
802-810
The biosynthesis of leucine: II. The enzymic isomerization of beta-carboxy-beta-hydroxyisocaproate and alpha-hydroxy-beta-carboxyisocaproate
1963
Gross, S.R.; Umbarger, H.E.
Biochemistry
2
1046-1052
Isopropylmalate dehydratase from yeast
1988
Kohlhaw, G.B.
Methods Enzymol.
166
423-429
3-Isopropylmalate is the major endogenous substrate of the Saccharomyces cerevisiae trans-aconitate methyltransferase
2004
Katz, J.E.; Dumlao, D.S.; Wasserman, J.I.; Lansdown, M.G.; Jung, M.E.; Faull, K.F.; Clarke, S.
Biochemistry
43
5976-5986
Links to other databases for 2-isopropylmaleate
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