Ligand 12-ketochenodeoxycholic acid

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Basic Ligand Information

Molecular Structure
Picture of 12-ketochenodeoxycholic acid (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C24H38O5
12-ketochenodeoxycholic acid
MIHNUBCEFJLAGN-DMMBONCOSA-N
Synonyms:
(3alpha,5beta,7alpha)-3,7-dihydroxy-12-oxocholan-24-oic acid, 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholan-24-oate, 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholan-24-oic acid, 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate, 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanoate, 12-oxochenodeoxycholic acid
Pathway Source
Pathways

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
12-ketochenodeoxycholic acid + NADH = cholic acid + NAD+
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
12-ketochenodeoxycholic acid + NAD+ = 7,12-diketochenodeoxycholic acid + NADH
show the reaction diagram
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3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanoate + NADPH = 3alpha,7alpha,12beta-trihydroxy-5beta-cholanoate + NADP+
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
inhibition of the ADH from Lactobacillus brevis by bile acids, acetone prevents partially
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Enzyme Kinetic Parameters

KM Value (2 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0012
-
-
0.274
-
-

References & Links

Links to other databases for 12-ketochenodeoxycholic acid

ChEBI
PubChem
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PubChem