Ligand estrone 3-sulfate

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Basic Ligand Information

Molecular Structure
Picture of estrone 3-sulfate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C18H22O5S
estrone 3-sulfate
JKKFKPJIXZFSSB-CBZIJGRNSA-N
Synonyms:
1,3,5(10)estatriene-3-ol-17-one 3-sulfate, 1,3,5(10)estatriene-3-ol 17-one 3-sulfate, esterone 3-sulfate, estrone-3-sulfate, Estrone sulfate, estronesulfate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
estronesulfate + NADPH = 17beta-estradiolsulfate + NADP+
show the reaction diagram
-
ATP + H2O + estrone-3-sulfate/in = ADP + phosphate + estrone-3-sulfate/out
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + H2O + estrone-3-sulfate/in = ADP + phosphate + estrone-3-sulfate/out
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
estrone 3-sulfate + NADPH + H+ = ?
show the reaction diagram
-
estrone 3-sulfate + NAD(P)H = 17alpha-estradiol 3-sulfate + NAD(P)+
show the reaction diagram
-
estronesulfate + NADPH = 17beta-estradiolsulfate + NADP+
show the reaction diagram
-
estrone sulfate + phenol = estrone + phenyl sulfate
show the reaction diagram
-
estrone 3-sulfate + H2O = sulfate + estrone
show the reaction diagram
-
estrone 3-sulfate + H2O = estrone + sulfate
show the reaction diagram
-
ATP + H2O + estrone-3-sulfate/in = ADP + phosphate + estrone-3-sulfate/out
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
estradiol sulfate + NADP+ = estrone sulfate + NADPH
show the reaction diagram
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3'-phosphoadenosine-5'-phosphosulfate + oestrone = adenosine 3',5'-bisphosphate + estrone sulfate
show the reaction diagram
-
-
3'-phosphoadenylylsulfate + estrone = adenosine 3',5'-bisphosphate + estrone sulfate
show the reaction diagram
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3'-phosphoadenylylsulfate + estrone = adenosine 3',5'-bisphosphate + estrone sulfate
show the reaction diagram
-
-
4-nitrophenyl sulfate + estrone = 4-nitrophenol + estrone 3-sulfate
show the reaction diagram
-
-
ATP + H2O + estrone-3-sulfate/in = ADP + phosphate + estrone-3-sulfate/out
show the reaction diagram
-
-

Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
the transport substrate stimulates the ATPase activity of MRP2
-

Inhibitor in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
about 50% residual activity at 0.1 mM (isoform PanK3)
-
IC50 is above 0.1 mM
-
IC50 is above 0.1 mM
-
IC50: 1.9 mM
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.098
-
at pH 7.4 and 37C

KM Value (12 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0067
-
at pH 7.4 and 37C
0.344
-
-

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.128
-
pH 8.1, 37C

IC50 Value (3 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.1
-
IC50 is above 0.1 mM
0.1
-
IC50 is above 0.1 mM
1.9
-
IC50: 1.9 mM

References & Links

Links to other databases for estrone 3-sulfate

ChEBI
PubChem
ChEBI
PubChem