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Ligand (S)-3-methyl-2-oxopentanoate Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C6 H1 0 O3
(S)-3-methyl-2-oxopentanoate
JVQYSWDUAOAHFM-BYPYZUCNSA-N
(3S)-3-methyl-2-oxopentanoate, (3S)-methyl-2-oxovalerate, (S)-2-oxo-3-methylpentanoate, (S)-3-Methyl-2-oxopentanoic acid, L-2-Oxo-3-methylpentanoate, L-3-Methyl-2-oxopentanoate, L-alpha-keto-beta-methylvalerate
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (6 results)
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(S)-2-oxo-3-methylpentanoate + reduced benzyl viologen = 2-hydroxy-3-methylpentanoate + oxidized benzyl viologen
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(S)-2-oxo-3-methylpentanoate + reduced methyl viologen = 2-hydroxy-3-methylpentanoate + oxidized methyl viologen
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L-alpha-keto-beta-methylvalerate + CoA + NAD+ = ?
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L-valine + (S)-3-methyl-2-oxopentanoate = 3-methyl-2-oxobutanoate + L-isoleucine
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L-glutamate + (S)-3-methyl-2-oxopentanoate = L-isoleucine + 2-oxoglutarate
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L-3-methyl-2-oxopentanoate = CO2 + 2-methylbutanal
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Product in Enzyme-catalyzed Reactions (1 result)
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S-adenosyl-L-ethionine + 2-oxobutyrate = S-adenosyl-L-homocysteine + (3S)-methyl-2-oxovalerate
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Activator in Enzyme-catalyzed Reactions (1 result)
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Inhibitor in Enzyme-catalyzed Reactions (2 results)
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3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)
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Enzyme Kinetic Parameters
KM Value (4 results)
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0.09
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pH 8.3, 37°C, leucine as amino group donor
0.17
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pH 8.0, 25°C, substrate L-glutamate
0.001
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and 2-oxoisopentanoate, 2-oxoisohexanoate, value below, 30°C, pH 7.5
References & Links Literature References (8)
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L-Aspartate-beta-decarboxylase. Structure, catalytic activities, and allosteric regulation
1971
Tate, S.S.; Meister, A.
Adv. Enzymol. Relat. Areas Mol. Biol.
35
503-543
Partial purification and properties of branched-chain 2-oxo acid dehydrogenase of ox liver
1978
Parker, P.J.; Randle, P.J.
Biochem. J.
171
751-757
Coenzyme A- and nicotinamide adenine dinucleotide-dependent branched chain alpha-keto acid dehydrogenase. I. Purification and properties of the enzyme from Bacillus subtilis
1969
Namba, Y.; Yoshizawa, K.; Ejima, A.; Hayashi, T.; Kaneda, T.
J. Biol. Chem.
244
4437-4447
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Separation of valine-glutamic aminotransferase from valine-isoleucine aminotransferase in pea sprouts
1967
Kagan, Z.S.; Dronov, A.S.; Kretovich, V.L.
Dokl. Akad. Nauk SSSR
175
1171-1174
Determination of branched-chain L-amino-acid aminotransferase activity
2000
Schadewaldt, P.
Methods Enzymol.
324
23-32
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On a non-pyridine nucleotide-dependent 2-oxoacid reductase of broad specificity from two Proteus species
1985
Neumann, S.; Simon, H.
FEBS Lett.
167
29-32
Biosynthesis of branched-chain fatty acids in Bacillus subtilis. A decarboxylase is essential for branched-chain fatty acid synthetase
1988
Oku, H.; Kaneda, T.
J. Biol. Chem.
263
18386-18396
Isolation of a branched-chain alpha-keto acid decarboxylase from rat liver
1979
Kean, E.A.; Morrison, E.Y.St.A.
Biochim. Biophys. Acta
567
12-17
Links to other databases for (S)-3-methyl-2-oxopentanoate
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