Ligand 6-deoxy-D-glucose

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Basic Ligand Information

Molecular Structure
Picture of 6-deoxy-D-glucose (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H12O5
6-deoxy-D-glucose
SHZGCJCMOBCMKK-VFUOTHLCSA-N
Synonyms:
beta-D-quinovose

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
6-deoxy-D-glucose + alpha-D-mannose 1-phosphate = 4-O-beta-D-mannopyranosyl-6-deoxy-D-glucopyranose + phosphate
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (25 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
6-deoxy-D-glucose + O2 = 2-keto-6-deoxy-D-glucose + H2O2
show the reaction diagram
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6-deoxy-D-glucose + pyrroloquinoline quinone = 6-deoxy-D-glucono-1,5-lactone + pyrroloquinoline quinol
show the reaction diagram
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6-deoxy-D-glucose + acceptor = ?
show the reaction diagram
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starch + 6-deoxy-D-glucose = ?
show the reaction diagram
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6-deoxy-D-glucose + alpha-D-mannose 1-phosphate = 4-O-beta-D-mannopyranosyl-6-deoxy-D-glucopyranose + phosphate
show the reaction diagram
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6-deoxy-D-glucose + alpha-D-glucose 1-phosphate = alpha-D-glucopyranosyl 6-deoxy-alpha-D-glucopyranoside + phosphate
show the reaction diagram
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6-deoxy-D-glucose + beta-D-glucose 1-phosphate = 4-O-alpha-D-glucopyranosyl-D-glucopyranose + phosphate
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
alpha-D-quinovose = beta-D-quinovose
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
the enzyme is produced exclusively in the presence of the specific inducer 6-deoxy-D-glucose, also named quinovose
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Inhibitor in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
substrate inhibition
-
competitive
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (10 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
177
-
pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
69.1
-
pH 8.0, 37°C

KM Value (13 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
1.3
-
wild-type enzyme
119
-
pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
5.68
-
pH 8.0, 37°C

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
50
-
at 37°C, pH 7.4
0.22
-
versus 4-methylumbelliferyl alpha-D-glucoside, pH 5.5, 45°C

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.4
-
pH 7.5, 37°C

References & Links

Links to other databases for 6-deoxy-D-glucose

ChEBI
PubChem
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PubChem