Ligand 4-acetylphenyl ethyl (S)-methylphosphonate
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Basic Ligand Information
Molecular Structure

C11H15O4P
4-acetylphenyl ethyl (S)-methylphosphonate
BJYIEMDHYADUGW-INIZCTEOSA-N
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (1 result)
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4-acetylphenyl ethyl (S)-methylphosphonate + H2O = 4-acetylphenol + ethyl (S)-methylphosphonate
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Enzyme Kinetic Parameters
kcat Value (Turnover Number) (5 results)
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mutant enzyme G60A, in 50 mM CHES (pH 9.0), at 30°C
110
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mutant enzyme H254G/H257W/L303T, in 50 mM CHES (pH 9.0), at 30°C
190
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mutant enzyme H275Y/L303T, in 50 mM CHES (pH 9.0), at 30°C
410
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mutant enzyme S308G, in 50 mM CHES (pH 9.0), at 30°C
290
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wild type enzyme, in 50 mM CHES (pH 9.0), at 30°C
670
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References & Links
Literature References (1)
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Stereoselective hydrolysis of organophosphate nerve agents by the bacterial phosphotriesterase
2010
Tsai, P.C.; Bigley, A.; Li, Y.; Ghanem, E.; Cadieux, C.L.; Kasten, S.A.; Reeves, T.E.; Cerasoli, D.M.; Raushel, F.M.
Biochemistry
49
7978-7987
Links to other databases for 4-acetylphenyl ethyl (S)-methylphosphonate