Ligand trans-2-hexenoyl-CoA

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Basic Ligand Information

Molecular Structure
Picture of trans-2-hexenoyl-CoA (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C27H44N7O17P3S
trans-2-hexenoyl-CoA
OINXHIBNZUUIMR-IXUYQXAASA-N
Synonyms:
(2E)-2-hexenoyl-CoA, (2E)-hex-2-enoyl-CoA, (2E)-hexenoyl-CoA, (E)-2-hexanoyl-CoA, 2-hexenoyl-CoA, 2-trans-hexenoyl-CoA, a medium-chain trans-2,3-dehydroacyl-CoA, hex-2-enoyl-CoA, hexenoyl-CoA, trans-hex-2-enoyl-CoA


Show all pahtways known for Show all BRENDA pathways known for trans-2-hexenoyl-CoA

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
trans-2-hexenoyl-CoA + NADPH + H+ = hexanoyl-CoA + NADP+
show the reaction diagram
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2-hexenoyl-CoA + reduced electron transfer flavoprotein = hexanoyl-CoA + electron transfer protein
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
hexanoyl-CoA + acceptor = hex-2-enoyl-CoA + reduced acceptor
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (22 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-trans-hexenoyl-CoA + NAD(P)H = hexanoyl-CoA + NADP+
show the reaction diagram
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(2E)-hex-2-enoyl-CoA + NADPH + CO2 + H+ = (S)-2-butylpropanedioyl-CoA + NADP+
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2-hexenoyl-CoA + reduced electron transfer flavoprotein = hexanoyl-CoA + electron transfer protein
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hexenoyl-CoA + H2O = ?
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trans-2-Hexenoyl-CoA + H2O = ?
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trans-2-hexenoyl-CoA + H2O = (3S)-3-hydroxyhexanoyl-CoA
show the reaction diagram
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trans-2-hexenoyl-CoA + H2O = 3-hydroxyhexanoyl-CoA
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Product in Enzyme-catalyzed Reactions (25 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
hexanoyl-CoA + O2 = (2E)-hex-2-enoyl-CoA + H2O2
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hexanoyl-CoA + electron-transfer flavoprotein = hex-2-enoyl-CoA + reduced electron-transfer flavoprotein
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive inhibition of crotonoyl-CoA reduction, but not of 2-trans-hexadecenoyl-CoA and 2-trans-decenoyl-CoA reduction
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3D Structure of Enzyme-Ligand-Complex (PDB) (3 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (20 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (35 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.048
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0.0005
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0.0263
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Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.00024
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pH 7.5, 25°C

References & Links

Links to other databases for trans-2-hexenoyl-CoA

ChEBI
PubChem
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PubChem