Ligand carbamazepine

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Basic Ligand Information

Molecular Structure
Picture of carbamazepine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C15H12N2O
carbamazepine
FFGPTBGBLSHEPO-UHFFFAOYSA-N
Synonyms:
carbamzepine

Show all pahtways known for Show all pathways known for carbamazepine

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
carbamazepine + H2O2 = 3-hydroxycarbamazepine + H2O
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
IC50 for morphine 3-glucuronide formation: 0.431 mM (mixed type inhibition), IC50 for morphine 3-glucuronide formation: 0.456 mM (mixed type inhibition)
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mechanism, reverses the effect of drugs
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carbamazepine preferentially inhibits forskolin-stimulated isoforms AC5 and AC1 and all D1 agonist-stimulated adenylate cyclases, with isoforms AC5 and AC7 being the most sensitive. When compared to 1 or 3 mM Mg2+, 10 mM Mg2+ reduces lithium-induced AC5 inhibition by 70%. Carbamazepine competes for adenylate cylcase's catechol-estrogen site
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Enzyme Kinetic Parameters

Ki Value (4 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

IC50 Value (2 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE

References & Links

Links to other databases for carbamazepine

ChEBI
PubChem
ChEBI
PubChem