print visible entries

print all entries

Ligand histone H4

Basic Ligand Information

Molecular Structure

close all tables

open all tables

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (11 results)

top print hide

Show Natural Substrate (11 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.257

acetyl-CoA + an N-terminal-L-seryl-[histone H4] = an N-terminal-Nalpha-acetyl-L-seryl-[histone H4] + CoA

659258, 720835, 735456, 741447, 740992

-

2.3.1.48

4 acetyl-CoA + histone H4 = 4 CoA + tetraacetylhistone H4

718912

-

2.3.1.48

acetyl-CoA + histone H4 = CoA + acetylhistone H4

702497, 703350, 703631, 704424, 736791, 736413, 659934, 659450, 658021, 659940, 659324, 702174, 703622, 702861, 702019, 705721, 703846, 704693, 735614, 737004, 736051, 736878, 736805

-

2.3.1.48

histone H4 + acetyl-CoA = acetyl-histone H4 + CoA

674726, 675911, 674902, 675976

-

2.3.1.48

acetyl-CoA + [histone H4]-L-lysine16 = CoA + [histone H4]-N6-acetyl-L-lysine16

756653, 756850, 756551

-

2.3.1.48

acetyl-CoA + [histone H4]-L-lysine5 = CoA + [histone H4]-N6-acetyl-L-lysine5

756850, 756428

-

2.3.1.48

acetyl-CoA + [histone H4]-L-lysine8 = CoA + [histone H4]-N6-acetyl-L-lysine8

756850

-

2.3.1.48

6 entries

3.4.21.37

histone H4 + H2O = ?

717895

-

3.4.21.78

histone H4 + H2O = ?

753077

-

3.5.3.15

histone H4-L-arginine + H2O = histone H4-L-citrulline + NH3

686367

-

6.3.4.10

ATP + biotin + histone H4 = AMP + diphosphate + biotin-histone H4

705293

-

In Vivo Product in Enzyme-catalyzed Reactions (5 results)

top print hide

Show Natural Product (5 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.286

NAD+ + [histone H4]-N6-acetyl-L-lysine16 = nicotinamide + [histone H4]-L-lysine16 + 2'-O-acetyl-ADP-ribose

0

-

2.3.1.B43

NAD+ + [histone H4]-N6-acetyl-L-lysine16 = nicotinamide + [histone H4]-L-lysine16 + 2'-O-acetyl-ADP-ribose

0

-

3.5.1.98

N-acetyl-Lys16-histone H4 + H2O = acetate + histone H4

0

-

3.5.1.98

N-acetyl-lysine-histone H4 + H2O = acetate + histone H4

0

-

3.5.1.98

2 entries

3.9.1.3

[histone H4]-N-phospho-L-histidine + H2O = [histone H4]-L-histidine + phosphate

0

-

Substrate in Enzyme-catalyzed Reactions (23 results)

top print hide

Show Substrate (23 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.1.1.355

S-adenosyl-L-methionine + histone H4 = S-adenosyl-L-homocysteine + ?

702068

-

2.3.1.257

acetyl-CoA + an N-terminal-L-seryl-[histone H4] = an N-terminal-Nalpha-acetyl-L-seryl-[histone H4] + CoA

659258, 720835, 735456, 741447, 740992

-

2.3.1.257

acetyl-CoA + histone H4 = CoA + Nalpha-acetyl-histone H4

720835

-

2.3.1.48

2 acetyl-CoA + histone H4 = 2 CoA + diacetylhistone H4

487086, 487085

-

2.3.1.48

3 acetyl-CoA + histone H4 = 3 CoA + triacetylhistone H4

487086

-

2.3.1.48

4 acetyl-CoA + histone H4 = 4 CoA + tetraacetylhistone H4

718912

-

2.3.1.48

acetyl-CoA + histone H4 = CoA + acetylhistone H4

702019, 487089, 686174, 687924, 702497, 703350, 703631, 704424, 705721, 736791, 487098, 658021, 686471, 487101, 487088, 704693, 736413, 720493, 487078, 487063, 487081, 487093, 487103, 487065, 487086, 487085, 487079, 487066, 487064, 487087, 487090, 487068, 487091, 487092, 659934, 659450, 659940, 659324, 660554, 702174, 703622, 702861, 703846, 704199, 705688, 735614, 737004, 736051, 736878, 736805

-

2.3.1.48

acetyl-CoA + histone H4 = Nalpha-acetylated-histone H4 + CoA

659258

-

2.3.1.48

acetyl-CoA + histone H4 = peptide CoA + acetylhistone H4 peptide

659934, 659940

-

2.3.1.48

histone H4 + acetyl-CoA = acetyl-histone H4 + CoA

674726, 675911, 674902, 672263, 675976, 675799

-

2.3.1.48

acetyl-CoA + [histone H4]-L-lysine16 = CoA + [histone H4]-N6-acetyl-L-lysine16

756657, 756653, 756850, 756551

-

2.3.1.48

acetyl-CoA + [histone H4]-L-lysine5 = CoA + [histone H4]-N6-acetyl-L-lysine5

756657, 756850, 756428

-

2.3.1.48

acetyl-CoA + [histone H4]-L-lysine8 = CoA + [histone H4]-N6-acetyl-L-lysine8

756657, 756850

-

2.3.1.257

2 entries

2.3.1.48

10 entries

2.7.11.1

ATP + histone H4 = ADP + phosphorylated histone H4

662857, 719695

-

2.7.13.1

ATP + histone H4 = ADP + phosphohistone H4

441642, 441645, 441644, 441637, 441638

-

2.7.13.2

ATP + histone H4 = ADP + phosphohistone H4

441638

-

3.4.21.37

histone H4 + H2O = ?

717895

-

3.4.21.78

histone H4 + H2O = ?

753077

-

3.4.22.8

histone H4 + H2O = ?

81589

-

3.5.3.15

histone H4 L-arginine + H2O = histone H4 L-citrulline + NH3

664107

-

3.5.3.15

histone H4-L-arginine + H2O = histone H4-L-citrulline + NH3

711811, 686367, 711246

-

3.5.3.15

[histone H4]-L-Arg + H2O = [histone H4]-L-citrulline + NH3

718900

-

3.5.3.15

3 entries

6.3.4.10

ATP + biotin + histone H4 = AMP + diphosphate + biotin-histone H4

705293

-

Product in Enzyme-catalyzed Reactions (10 results)

top print hide

Show Product (10 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.286

NAD+ + [histone H4]-N6-acetyl-L-lysine16 = nicotinamide + [histone H4]-L-lysine16 + 2'-O-acetyl-ADP-ribose

0

-

2.3.1.286

[histone H4]-N6-acetyl-L-lysine16 + NAD+ + H2O = [histone H4]-L-lysine16 + 2''-O-acetyl-ADP-D-ribose + nicotinamide

0

-

2.3.1.286

[histone H4]-N6-acetyl-L-lysine5 + NAD+ + H2O = [histone H4]-L-lysine5 + 2''-O-acetyl-ADP-D-ribose + nicotinamide

0

-

2.3.1.286

NAD+ + [histone H4]-N6-acetyl-L-lysine8 = nicotinamide + [histone H4]-L-lysine8 + 2'-O-acetyl-ADP-ribose

0

-

2.3.1.286

[histone H4]-N6-acetyl-L-lysine8 + NAD+ + H2O = [histone H4]-L-lysine8 + 2''-O-acetyl-ADP-D-ribose + nicotinamide

0

-

2.3.1.286

5 entries

2.3.1.B43

NAD+ + [histone H4]-N6-acetyl-L-lysine16 = nicotinamide + [histone H4]-L-lysine16 + 2'-O-acetyl-ADP-ribose

0

-

3.5.1.98

N-acetyl-Lys16-histone H4 + H2O = acetate + histone H4

0

-

3.5.1.98

N-acetyl-lysine-histone H4 + H2O = acetate + histone H4

0

-

3.5.1.98

N6-lysine acetylated histone H4 + H2O = histone H4 + acetate

0

-

3.5.1.98

3 entries

3.9.1.3

[histone H4]-N-phospho-L-histidine + H2O = [histone H4]-L-histidine + phosphate

0

-

Activator in Enzyme-catalyzed Reactions (1 result)

top print hide

Show Activating Compound (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.1.1.359

in the presence of histone H4, there is a 5-7fold increase in enzyme activity on histone H3

753739

-

Inhibitor in Enzyme-catalyzed Reactions (1 result)

top print hide

Show Inhibitors (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.48

-

487078

-

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (25 results)

top print hide

Show Turnover Number (25 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

2.3.1.48

0.0018

-

pH 7.5, 25°C, mutant Y612C

703631

2.3.1.48

0.003

-

pH 7.5, 25°C, mutant L503P/D601G/Y612C

703631

2.3.1.48

0.0035

-

pH 7.5, 25°C, mutant Y612C/P655R

703631

2.3.1.48

0.0048

-

pH 7.5, 25°C, wild-type P/CAF enzyme and mutant V582A

703631

2.3.1.48

0.0053

-

pH 7.5, 25°C, mutant L503P

703631

2.3.1.48

0.0055

-

pH 7.5, 25°C, mutant D601G

703631

2.3.1.48

0.0058

-

pH 7.5, 25°C, mutant D639E

703631

2.3.1.48

0.0062

-

pH 7.5, 25°C, mutant V582A/D639E

703631

3.5.3.15

0.49

-

37°C, pH 7.6, mutant R374K

718900

3.5.3.15

0.77

-

37°C, pH 7.6, mutant R374Q

718900

3.5.3.15

0.78

-

37°C, pH 7.6, mutant R639Q

718900

3.5.3.15

0.79

-

37°C, pH 7.6, mutant R156Q

718900

3.5.3.15

0.9

-

37°C, pH 7.6, mutant R123Q

718900

3.5.3.15

1

-

37°C, pH 7.6, mutant A112G

718900

3.5.3.15

1.1

-

37°C, pH 7.6, mutant S55G

718900

3.5.3.15

1.2

-

37°C, pH 7.6, mutant R419Q

718900

3.5.3.15

1.3

-

37°C, pH 7.6, mutant R419K

718900

3.5.3.15

1.3

-

37°C, pH 7.6, mutant R639K

718900

3.5.3.15

1.4

-

37°C, pH 7.6, mutant A82V

718900

3.5.3.15

1.4

-

37°C, pH 7.6, mutant R156K

718900

3.5.3.15

1.5

-

37°C, pH 7.6, mutant R609Q

718900

3.5.3.15

1.6

-

37°C, pH 7.6, mutant R484K

718900

3.5.3.15

1.6

-

37°C, pH 7.6, mutant R484Q

718900

3.5.3.15

1.7

-

37°C, pH 7.6, mutant R123K

718900

3.5.3.15

2.1

-

37°C, pH 7.6, wild-type

718900

2.3.1.48

8 entries

3.5.3.15

17 entries

K_M Value (31 results)

top print hide

Show KM Value (31 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.3.1.48

0.0000053

-

in the absence of heparin

687924

2.3.1.48

0.000259

-

in the presence of heparin

687924

2.3.1.48

0.11

-

pH 7.5, 25°C, mutant L503P/D601G/Y612C

703631

2.3.1.48

0.12

-

pH 7.5, 25°C, mutant Y612C

703631

2.3.1.48

0.14

-

pH 7.5, 25°C, mutant Y612C/P655R

703631

2.3.1.48

0.15

-

pH 7.5, 25°C, mutant D639E

703631

2.3.1.48

0.19

-

pH 7.5, 25°C, wild-type P/CAF enzyme

703631

2.3.1.48

0.21

-

pH 7.5, 25°C, mutant L503P

703631

2.3.1.48

0.25

-

pH 7.5, 25°C, mutant D601G

703631

2.3.1.48

0.31

-

pH 7.5, 25°C, mutant V582A/D639E

703631

2.3.1.48

0.5

-

pH 7.5, 25°C, mutant V582A

703631

2.7.13.1

0.014

-

-

441642

2.7.13.1

0.017

-

-

441644

3.5.3.15

0.088

-

37°C, pH 7.6, mutant R374K

718900

3.5.3.15

0.094

-

37°C, pH 7.6, mutant R639Q

718900

3.5.3.15

0.1

-

37°C, pH 7.6, mutant R123Q

718900

3.5.3.15

0.11

-

37°C, pH 7.6, mutant R156Q

718900

3.5.3.15

0.14

-

isozyme PAD4, at 37°C, 10 mM CaCl2, 50 mM NaCl, 100 mM Tris-HCl, pH 7.6, 2 mM dithiothreitol

711246

3.5.3.15

0.14

-

37°C, pH 7.6, mutant R419K

718900

3.5.3.15

0.15

-

37°C, pH 7.6, mutant R374Q

718900

3.5.3.15

0.15

-

37°C, pH 7.6, mutant R639K

718900

3.5.3.15

0.17

-

37°C, pH 7.6, mutant A112G

718900

3.5.3.15

0.18

-

37°C, pH 7.6, mutant R156K

718900

3.5.3.15

0.18

-

37°C, pH 7.6, mutant R609Q

718900

3.5.3.15

0.2

-

37°C, pH 7.6, mutant S55G

718900

3.5.3.15

0.21

-

37°C, pH 7.6, wild-type

718900

3.5.3.15

0.22

-

37°C, pH 7.6, mutant R419Q

718900

3.5.3.15

0.24

-

37°C, pH 7.6, mutant R123K

718900

3.5.3.15

0.26

-

37°C, pH 7.6, mutant R484K

718900

3.5.3.15

0.3

-

37°C, pH 7.6, mutant R484Q

718900

3.5.3.15

0.35

-

37°C, pH 7.6, mutant A82V

718900

2.3.1.48

11 entries

2.7.13.1

2 entries

3.5.3.15

18 entries

References & Links

Literature References (85)

top print hide

Show Reference (85 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

81589

3172232

Chromatin core particle obtained by selective cleavage of histones H3 and H4 by clostripain

1988

Encontre, I.; Parello, J.

J. Mol. Biol.

202

673-676

441637

4066704

Phosphorylation of histidine in proteins by a nuclear extract of Physarum polycephalum plasmodia

1985

Huebner, V.D.; Matthews, H.R.

J. Biol. Chem.

260

16106-16113

441638

7196259

Characterization of chemical and enzymatic acid-labile phosphorylation of histone H4 using phosphorus-31 nuclear magnetic resonance

1981

Fujikati, J.M.; Fung, G.; Oh, E.Y.; Smith, R.A.

Biochemistry

20

3658-3664

441642

1639791

Genistein inhibits protein histidine kinase

1992

Huang, J.; Nasr, M.; Kim, Y.; Matthews, H.R.

J. Biol. Chem.

267

15511-15515

441644

2026610

Purification of a protein histidine kinase from the yeast Saccharomyces cerevisiae. The first member of this class of protein kinases

1991

Huang, J.; Wei, Y.K.; Osterberg, L.; Matthews, H.R.

J. Biol. Chem.

266

9023-9031

441645

2643923

Studies of histidine phosphorylation by a nuclear protein histidine kinase show that histidine-75 in histone H4 is masked in nucleosome core particles and in chromatin

1989

Wei, Y.F.; Morgan, J.E.; Matthews, H.R.

Arch. Biochem. Biophys.

268

546-550

487063

-

On the ubiquitous presence of histone acetyltransferase B in eukaryotes

1985

Salvador, M.L.; Sendra, R.; Lopez-Rodas, G.; Tordera, V.; Franco, L.

FEBS Lett.

191

55-58

487064

7406506

Rat liver nuclear N-acetyltransferases: separation of two enzymes with both histone and spermidine acetyltransferase activity

1980

Libby, P.R.

Arch. Biochem. Biophys.

203

384-389

487065

3890750

Partial purification and properties of two histone acetyltransferases from the yeast, Saccharomyces cerevisiae

1985

Lopez-Rodas, G.; Perez-Ortin, J.E.; Tordera, V.; Salvador, M.L.; Franco, L.

Arch. Biochem. Biophys.

239

184-190

487066

1730297

Enzymes involved in the dynamic equilibrium of core histone acetylation of Physarum polycephalum

1992

Lopez-Rodas, G.; Brosch, G.; Golderer, G.; Lindner, H.; Grobner, P.; Loidl, P.

FEBS Lett.

296

82-86

487068

6389549

Extensive purification and characterization of chromatin-bound histone acetyltransferase from Saccharomyces cerevisiae

1984

Travis, G.H.; Colavito-Shepanski, M.; Grunstein, M.

J. Biol. Chem.

259

14406-14412

487078

6783663

Histone acetylase from Drosophila melanogaster specific for H4

1981

Wiegand, R.C.; Brutlag, D.L.

J. Biol. Chem.

256

4578-4583

487079

7440548

Comparative studies of histone acetylation in nucleosomes, nuclei, and intact cells. Evidence for special factors which modify acetylase action

1980

Garcea, R.L.; Alberts, B.M.

J. Biol. Chem.

255

11454-11463

487081

7356970

Histone-specific acetyltransferases from calf thymus. Isolation, properties, and substrate specificity of three different enzymes

1980

Sures, I.; Gallwitz, D.

Biochemistry

19

943-951

487085

8635608

Purification and characterization of the cytoplasmic histone acetyltransferase B of maize embryos

1996

Eberharter, A.; Lechner, T.; Goralik-Schramel, M.; Loidl, P.

FEBS Lett.

386

75-81

487086

8514763

Site specificity of pea histone acetyltransferase B in vitro

1993

Mingarro, I.; Sendra, R.; Salvador, M.L.; Franco, L.

J. Biol. Chem.

268

13248-13252

487087

9341171

The histone acetyltransferase activity of human GCN5 and PCAF is stabilized by coenzymes

1997

Herrera, J.E.; Bergel, M.; Yang, X.J.; Nakatani, Y.; Bustin, M.

J. Biol. Chem.

272

27253-27258

487088

9388189

Novel substrate specificity of the histone acetyltransferase activity of HIV-1-Tat interactive protein Tip60

1997

Yamamoto, T.; Horikoshi, M.

J. Biol. Chem.

272

30595-30598

487089

10395565

Gene activation by histone and factor acetyltransferases

1999

Berger, S.L.

Curr. Opin. Cell Biol.

11

336-341

487090

10497217

Identification of a human histone acetyltransferase related to monocytic leukemia zinc finger protein

1999

Champagne, N.; Bertos, N.R.; Pelletier, N.; Wang, A.H.; Vezmar, M.; Yang, Y.; Heng, H.H.; Yang, X.J.

J. Biol. Chem.

274

28528-28536

487091

10600516

Sas3 is a histone acetyltransferase and requires a zinc finger motif

1999

Takechi, S.; Nakayama, T.

Biochem. Biophys. Res. Commun.

266

405-410

487092

10082517

Esa1p is an essential histone acetyltransferase required for cell cycle progression

1999

Clarke, A.S.; Lowell, J.E.; Jacobson, S.J.; Pillus, L.

Mol. Cell. Biol.

19

2515-2526

487093

10022893

A novel H2A/H4 nucleosomal histone acetyltransferase in Tetrahymena thermophila

1999

Ohba, R.; Steger, D.J.; Brownell, J.E.; Mizzen, C.A.; Cook, R.G.; Cote, J.; Workman, J.L.; Allis, C.D.

Mol. Cell. Biol.

19

2061-2068

487098

11112280

Application of a fluorescent histone acetyltransferase assay to probe the substrate specificity of the human p300/CBP-associated factor

2000

Trievel, R.C.; Li, F.Y.; Marmorstein, R.

Anal. Biochem.

287

319-328

487101

12185447

Histone acetyl transferases: a role in DNA repair and DNA replication

2002

Hasan, S.; Hottiger, M.O.

J. Mol. Med.

80

463-474

487103

12626510

Sas4 and Sas5 are required for the histone acetyltransferase activity of Sas2 in the SAS complex

2003

Sutton, A.; Shia, W.J.; Band, D.; Kaufman, P.D.; Osada, S.; Workman, J.L.; Sternglanz, R.

J. Biol. Chem.

278

16887-16892

658021

15311944

Histone methyltransferases in Aspergillus nidulans: evidence for a novel enzyme with a unique substrate specificity

2004

Trojer, P.; Dangl, M.; Bauer, I.; Graessle, S.; Loidl, P.; Brosch, G.

Biochemistry

43

10834-10843

659258

12915400

An Nalpha-acetyltransferase responsible for acetylation of the N-terminal residues of histones H4 and H2A

2003

Song, O.k.; Wang, X.; Waterborg, J.H.; Sternglanz, R.

J. Biol. Chem.

278

38109-38112

659324

14761951

Hif1 is a component of yeast histone acetyltransferase B, a complex mainly localized in the nucleus

2004

Poveda, A.; Pamblanco, M.; Tafrov, S.; Tordera, V.; Sternglanz, R.; Sendra, R.

J. Biol. Chem.

279

16033-16043

659450

15659401

Characterization of the yeast trimeric-SAS acetyltransferase complex

2005

Shia, W.J.; Osada, S.; Florens, L.; Swanson, S.K.; Washburn, M.P.; Workman, J.L.

J. Biol. Chem.

280

11987-11994

659934

12917332

Yaf9, a novel NuA4 histone acetyltransferase subunit, is required for the cellular response to spindle stress in yeast

2003

Le Masson, I.; Yu, D.Y.; Jensen, K.; Chevalier, A.; Courbeyrette, R.; Boulard, Y.; Smith, M.M.; Mann, C.

Mol. Cell. Biol.

23

6086-6102

659940

16024812

hMOF histone acetyltransferase is required for histone H4 lysine 16 acetylation in mammalian cells

2005

Taipale, M.; Rea, S.; Richter, K.; Vilar, A.; Lichter, P.; Imhof, A.; Akhtar, A.

Mol. Cell. Biol.

25

6798-6810

660554

12801725

The diverse functions of histone acetyltransferase complexes

2003

Carrozza, M.J.; Utley, R.T.; Workman, J.L.; Cote, J.

Trends Genet.

19

321-329

662857

15870294

Identification and characterization of SSTK, a serine/threonine protein kinase essential for male fertility

2005

Spiridonov, N.A.; Wong, L.; Zerfas, P.M.; Starost, M.F.; Pack, S.D.; Paweletz, C.P.; Johnson, G.R.

Mol. Cell. Biol.

25

4250-4261

664107

15823041

Deimination of histone H2A and H4 at arginine 3 in HL-60 granulocytes

2005

Hagiwara, T.; Hidaka, Y.; Yamada, M.

Biochemistry

44

5827-5834

672263

17223684

Catalytic mechanism of a MYST family histone acetyltransferase

2007

Berndsen, C.E.; Albaugh, B.N.; Tan, S.; Denu, J.M.

Biochemistry

46

623-629

674726

16356930

The histone acetyltransferase NCOAT contains a zinc finger-like motif involved in substrate recognition

2006

Toleman, C.A.; Paterson, A.J.; Kudlow, J.E.

J. Biol. Chem.

281

3918-3925

674902

17052979

Properties of the type B histone acetyltransferase Hat1: H4 tail interaction, site preference, and involvement in DNA repair

2007

Benson, L.J.; Phillips, J.A.; Gu, Y.; Parthun, M.R.; Hoffman, C.S.; Annunziato, A.T.

J. Biol. Chem.

282

836-842

675799

17309836

Expression and purification of recombinant yeast Ada2/Ada3/Gcn5 and Piccolo NuA4 histone acetyltransferase complexes

2007

Barrios, A.; Selleck, W.; Hnatkovich, B.; Kramer, R.; Sermwittayawong, D.; Tan, S.

Methods

41

271-277

675911

16227401

Isothiazolones as inhibitors of PCAF and p300 histone acetyltransferase activity

2005

Stimson, L.; Rowlands, M.G.; Newbatt, Y.M.; Smith, N.F.; Raynaud, F.I.; Rogers, P.; Bavetsias, V.; Gorsuch, S.; Jarman, M.; Bannister, A.; Kouzarides, T.; McDonald, E.; Workman, P.; Aherne, G.W.

Mol. Cancer Ther.

4

1521-1532

675976

17030603

The Drosophila histone acetyltransferase Gcn5 and transcriptional adaptor Ada2a are involved in nucleosomal histone H4 acetylation

2006

Ciurciu, A.; Komonyi, O.; Pankotai, T.; Boros, I.M.

Mol. Cell. Biol.

26

9413-9423

686174

18325031

Montelukast inhibits tumour necrosis factor-alpha-mediated interleukin-8 expression through inhibition of nuclear factor-kappaB p65-associated histone acetyltransferase activity

2008

Tahan, F.; Jazrawi, E.; Moodley, T.; Rovati, G.E.; Adcock, I.M.

Clin. Exp. Allergy

38

805-811

686367

-

Targeting optic nerve citrullination in glaucoma: a role for protein-arginine deiminase 2 (PAD2) inhibitors

2007

Algeciras, M.E.; Bhattacharya, S.K.

Drugs Future

32

999-1005

686471

18487348

Histone acetyltransferase inhibitor anacardic acid causes changes in global gene expression during in vitro Plasmodium falciparum development

2008

Cui, L.; Miao, J.; Furuya, T.; Fan, Q.; Li, X.; Rathod, P.K.; Su, X.Z.; Cui, L.

Eukaryot. Cell

7

1200-1210

687924

18459114

Inhibition of histone acetyltransferase by glycosaminoglycans

2008

Buczek-Thomas, J.A.; Hsia, E.; Rich, C.B.; Foster, J.A.; Nugent, M.A.

J. Cell. Biochem.

105

108-120

702019

18601901

Histone acetyltransferase-1 regulates integrity of cytosolic histone H3-H4 containing complex

2008

Barman, H.K.; Takami, Y.; Nishijima, H.; Shibahara, K.; Sanematsu, F.; Nakayama, T.

Biochem. Biophys. Res. Commun.

373

624-630

702068

19646955

Histone methyltransferase PRDM8 regulates mouse testis steroidogenesis

2009

Eom, G.H.; Kim, K.; Kim, S.M.; Kee, H.J.; Kim, J.Y.; Jin, H.M.; Kim, J.R.; Kim, J.H.; Choe, N.; Kim, K.B.; Lee, J.; Kook, H.; Kim, N.; Seo, S.B.

Biochem. Biophys. Res. Commun.

388

131-136

702174

18774930

Structure and function of MYST1 histone acetyltransferase in the interactome of animal cells

2008

Dmitriev, R.I.; Shakhparonov, M.I.; Pestov, N.B.

Biochemistry (Moscow)

73

839-852

702497

19722182

MYST family histone acetyltransferases take center stage in stem cells and development

2009

Voss, A.K.; Thomas, T.

Bioessays

31

1050-1061

702861

20068219

H4R3 methylation facilitates beta-globin transcription by regulating histone acetyltransferase binding and H3 acetylation

2010

Li, X.; Hu, X.; Patel, B.; Zhou, Z.; Liang, S.; Ybarra, R.; Qiu, Y.; Felsenfeld, G.; Bungert, J.; Huang, S.

Blood

115

2028-2037

703350

19056256

Catalysis and substrate selection by histone/protein lysine acetyltransferases

2008

Berndsen, C.E.; Denu, J.M.

Curr. Opin. Struct. Biol.

18

682-689

703622

18373695

Site specificity of yeast histone acetyltransferase B complex in vivo

2008

Poveda, A.; Sendra, R.

FEBS J.

275

2122-2136

703631

18959749

Directed evolution of a histone acetyltransferase - enhancing thermostability, whilst maintaining catalytic activity and substrate specificity

2008

Leemhuis, H.; Nightingale, K.P.; Hollfelder, F.

FEBS J.

275

5635-5647

703846

19393168

Histone acetyltransferase Hbo1: catalytic activity, cellular abundance, and links to primary cancers

2009

Iizuka, M.; Takahashi, Y.; Mizzen, C.A.; Cook, R.G.; Fujita, M.; Allis, C.D.; Frierson, H.F.; Fukusato, T.; Smith, M.M.

Gene

436

108-114

704199

20063892

Analysis of p300/CBP histone acetyltransferase regulation using circular permutation and semisynthesis

2010

Karukurichi, K.R.; Wang, L.; Uzasci, L.; Manlandro, C.M.; Wang, Q.; Cole, P.A.

J. Am. Chem. Soc.

132

1222-1223

704424

18397880

Activation of p300 histone acetyltransferase activity is an early endothelial response to laminar shear stress and is essential for stimulation of endothelial nitric-oxide synthase mRNA transcription

2008

Chen, W.; Bacanamwo, M.; Harrison, D.G.

J. Biol. Chem.

283

16293-16298

704693

20018852

Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex

2009

Cai, Y.; Jin, J.; Swanson, S.K.; Cole, M.D.; Choi, S.H.; Florens, L.; Washburn, M.P.; Conaway, J.W.; Conaway, R.C.

J. Biol. Chem.

285

4268-4272

705293

19369050

K12-biotinylated histone H4 is enriched in telomeric repeats from human lung IMR-90 fibroblasts

2010

Wijeratne, S.S.; Camporeale, G.; Zempleni, J.

J. Nutr. Biochem.

21

310-316

705688

19103755

The double-histone-acetyltransferase complex ATAC is essential for mammalian development

2009

Guelman, S.; Kozuka, K.; Mao, Y.; Pham, V.; Solloway, M.J.; Wang, J.; Wu, J.; Lill, J.R.; Zha, J.

Mol. Cell. Biol.

29

1176-1188

705721

20129055

HBO1 histone acetylase activity is essential for DNA replication licensing and inhibited by geminin

2010

Miotto, B.; Struhl, K.

Mol. Cell

37

57-66

711246

20469888

Substrate specificity and kinetic studies of PADs 1, 3, and 4 identify potent and selective inhibitors of protein arginine deiminase 3

2010

Knuckley, B.; Causey, C.P.; Jones, J.E.; Bhatia, M.; Dreyton, C.J.; Osborne, T.C.; Takahara, H.; Thompson, P.R.

Biochemistry

49

4852-4863

711811

19736621

Protein arginine deiminase 4 (PAD4): Current understanding and future therapeutic potential

2009

Jones, J.E.; Causey, C.P.; Knuckley, B.; Slack-Noyes, J.L.; Thompson, P.R.

Curr. Opin. Drug Discov. Devel.

12

616-627

717895

20974816

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

2010

Papayannopoulos, V.; Metzler, K.D.; Hakkim, A.; Zychlinsky, A.

J. Cell Biol.

191

677-691

718900

21466234

Autodeimination of protein arginine deiminase 4 alters protein-protein interactions but not activity

2011

Slack, J.L.; Jones, L.E.; Bhatia, M.M.; Thompson, P.R.

Biochemistry

50

3997-4010

718912

21182309

Processing mechanism and substrate selectivity of the core NuA4 histone acetyltransferase complex

2011

Arnold, K.M.; Lee, S.; Denu, J.M.

Biochemistry

50

727-737

719695

10852877

The archaeon Sulfolobus solfataricus contains a membrane-associated protein kinase activity that preferentially phosphorylates threonine residues in vitro

2000

Lower, B.H.; Bischoff, K.M.; Kennelly, P.J.

J. Bacteriol.

182

3452-3459

720493

20807207

The MYST family histone acetyltransferase regulates gene expression and cell cycle in malaria parasite Plasmodium falciparum

2010

Miao, J.; Fan, Q.; Cui, L.; Li, X.; Wang, H.; Ning, G.; Reese, J.C.; Cui, L.

Mol. Microbiol.

78

883-902

720835

21935442

The human N-alpha-acetyltransferase 40 (hNaa40p/hNatD) is conserved from yeast and N-terminally acetylates histones H2A and H4

2011

Hole, K.; van Damme, P.; Dalva, M.; Aksnes, H.; Glomnes, N.; Varhaug, J.; Lillehaug, J.; Gevaert, K.; Arnesen, T.

PLoS ONE

6

e24713

735456

26666750

Depletion of histone N-terminal-acetyltransferase Naa40 induces p53-independent apoptosis in colorectal cancer cells via the mitochondrial pathway

2015

Pavlou, D.; Kirmizis, A.

Apoptosis

21

298-311

735614

26456646

Histone acetyltransferase PCAF is involved in transactivation of Bcl-6 and Pax5 genes in immature B cells

2015

Kikuchi, H.; Nakayama, M.; Kuribayashi, F.; Mimuro, H.; Imajoh-Ohmi, S.; Nishitoh, H.; Nakayama, T.

Biochem. Biophys. Res. Commun.

467

509-513

736051

26505788

Enzyme kinetics and inhibition of histone acetyltransferase KAT8

2015

Wapenaar, H.; van der Wouden, P.E.; Groves, M.R.; Rotili, D.; Mai, A.; Dekker, F.J.

Eur. J. Med. Chem.

105

289-296

736413

23543735

Lysine acetyltransferase GCN5 potentiates the growth of non-small cell lung cancer via promotion of E2F1, cyclin D1, and cyclin E1 expression

2013

Chen, L.; Wei, T.; Si, X.; Wang, Q.; Li, Y.; Leng, Y.; Deng, A.; Chen, J.; Wang, G.; Zhu, S.; Kang, J.

J. Biol. Chem.

288

14510-14521

736791

23981651

Histone acetyltransferase PCAF up-regulated cell apoptosis in hepatocellular carcinoma via acetylating histone H4 and inactivating AKT signaling

2013

Zheng, X.; Gai, X.; Ding, F.; Lu, Z.; Tu, K.; Yao, Y.; Liu, Q.

Mol. Cancer

12

96

736805

25578876

Global and specific responses of the histone acetylome to systematic perturbation

2015

Feller, C.; Forne, I.; Imhof, A.; Becker, P.B.

Mol. Cell

57

559-571

736878

23863932

The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy

2013

Fuellgrabe, J.; Lynch-Day, M.A.; Heldring, N.; Li, W.; Struijk, R.B.; Ma, Q.; Hermanson, O.; Rosenfeld, M.G.; Klionsky, D.J.; Joseph, B.

Nature

500

468-471

737004

26576681

Histone acetyltransferase GCN5 is essential for heat stress-responsive gene activation and thermotolerance in Arabidopsis

2015

Hu, Z.; Song, N.; Zheng, M.; Liu, X.; Liu, Z.; Xing, J.; Ma, J.; Guo, W.; Yao, Y.; Peng, H.; Xin, M.; Zhou, D.X.; Ni, Z.; Sun, Q.

Plant J.

84

1178-1191

740992

19332560

Properties of Nat4, an Nalpha-acetyltransferase of Saccharomyces cerevisiae that modifies N termini of histones H2A and H4

2009

Polevoda, B.; Hoskins, J.; Sherman, F.

Mol. Cell. Biol.

29

2913-2924

741447

25619998

The molecular basis for histone H4- and H2A-specific amino-terminal acetylation by NatD

2015

Magin, R.; Liszczak, G.; Marmorstein, R.

Structure

23

332-341

753077

27439606

Histone H4 is cleaved by granzyme A during staurosporine-induced cell death in B-lymphoid Raji cells

2016

Lee, P.; Park, B.; Chi, S.; Bae, K.; Kim, S.; Cho, S.; Kang, S.; Kim, J.; Park, S.

BMB Rep.

49

560-565

753739

18923077

Histone H3 K36 methylation is mediated by a trans-histone methylation pathway involving an interaction between Set2 and histone H4

2008

Du, H.N.; Fingerman, I.M.; Briggs, S.D.

Genes Dev.

22

2786-2798

756428

30637990

Bisubstrate inhibitors to target histone acetyltransferase 1

2019

Ngo, L.; Brown, T.; Zheng, Y.G.

Chem. Biol. Drug Des.

93

865-873

756551

-

Histone acetyltransferase KAT8 is essential for mouse oocyte development by regulating reactive oxygen species levels

2017

Yin, S.; Jiang, X.; Jiang, H.; Gao, Q.; Wang, F.; Fan, S.; Khan, T.; Jabeen, N.; Khan, M.; Ali, A.; Xu, P.; Pandita, T.; Fan, H.; Zhang, Y.; Shi, Q.

Development

144

2165-2174

756653

30145373

Identification of novel inhibitors of histone acetyltransferase hMOF through high throughput screening

2018

Zhang, R.; Wang, J.; Zhao, L.; Liu, S.; Du, D.; Ding, H.; Chen, S.; Yue, L.; Liu, Y.C.; Zhang, C.; Liu, H.; Luo, C.

Eur. J. Med. Chem.

157

867-876

756657

31195169

Histone acetyltransferase inhibitors An overview in synthesis, structure-activity relationship and molecular mechanism

2019

Huang, M.; Huang, J.; Zheng, Y.; Sun, Q.

Eur. J. Med. Chem.

178

259-286

756850

29676588

Lysine acetyltransferase inhibitors structure-activity relationships and potential therapeutic implications

2018

Fiorentino, F.; Mai, A.; Rotili, D.

Future Med. Chem.

10

1067-1091

Links to other databases for histone H4

top print hide

Show Links (1 entry)