Ligand trimethylamine N-oxide

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Basic Ligand Information

Molecular Structure
Picture of trimethylamine N-oxide (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C3H9NO
trimethylamine N-oxide
UYPYRKYUKCHHIB-UHFFFAOYSA-N
Synonyms:
(CH3)3NO, N,N,N-trimethylamine N-oxide, Trimethylamine-N-oxide

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
Trimethylamine N-oxide = Dimethylamine + formaldehyde
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
N,N,N-trimethylamine + NADPH + H+ + O2 = N,N,N-trimethylamine N-oxide + NADP+ + H2O
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
trimethylamine N-oxide + reduced methyl viologen + H2O = ?
show the reaction diagram
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trimethylamine N-oxide + reduced benzyl viologen = trimethylamine + oxidized benzyl viologen + H2O
show the reaction diagram
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Trimethylamine N-oxide = Dimethylamine + formaldehyde
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Activator in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
stimulates enzyme self-association and interaction with glycogen, prevents complex formation with phosphorylase b
-
concentration of 4 M required for activity, at pH 8 inclusion of low concentrations of NaCl required for activation
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it enhances the enzyme activity 2.5fold at 50C and 3 M, and 5fold at 45C and 1 M, while it reduces the enzyme activity at 35-40C, by 60% at 40C and 3 M, 10% at 1 M, overview
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enhances cleavage of unmodified tRNA and anticodon stem loops by gamma-toxin-GST
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Inhibitor in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
stimulates enzyme self-association and interaction with glycogen, prevents complex formation with phosphorylase b
-
it enhances the enzyme activity 2.5fold at 50C and 3 M, and 5fold at 45C and 1 M, while it reduces the enzyme activity at 35-40C, by 60% at 40C and 3 M, 10% at 1 M, overview
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3D Structure of Enzyme-Ligand-Complex (PDB) (11 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (13 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (26 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for trimethylamine N-oxide

ChEBI
PubChem
ChEBI
PubChem