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Ligand (E)-2-oxo-4(pyridin-3-yl)-3-but-3-enoic acid Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C9 H7 NO3
(E)-2-oxo-4(pyridin-3-yl)-3-but-3-enoic acid
ROXNESLCSLAKKG-ONEGZZNKSA-N
(3E)-2-oxo-4-pyridin-3-ylbut-3-enoate, (E)-2-oxo-4(pyridin-3-yl)-3-butenoic acid
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (3 results)
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(E)-2-oxo-4(pyridin-3-yl)-3-butenoic acid = (E)-3-(3-pyridyl)acrylic acid + 3-(pyridin-3-yl)acrylaldehyde + CO2
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(E)-2-oxo-4(pyridin-3-yl)-3-butenoic acid = 3-(pyridin-3-yl)acrylaldehyde + CO2
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(E)-2-oxo-4(pyridin-3-yl)-3-but-3-enoic acid = (E)-3-(pyridine-3-yl)acrylaldehyde
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Product in Enzyme-catalyzed Reactions (1 result)
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3-pyridinecarboxaldehyde + pyruvate = (3E)-2-oxo-4-pyridin-3-ylbut-3-enoate + H2O
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Enzyme Kinetic Parameters
References & Links Literature References (3)
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Mechanism of benzaldehyde lyase studied via thiamin diphosphate-bound intermediates and kinetic isotope effects
2008
Chakraborty, S.; Nemeria, N.; Yep, A.; McLeish, M.J.; Kenyon, G.L.; Jordan, F.
Biochemistry
47
3800-3809
Detection and time course of formation of major thiamin diphosphate-bound covalent intermediates derived from a chromophoric substrate analogue on benzoylformate decarboxylase
2009
Chakraborty, S.; Nemeria, N.S.; Balakrishnan, A.; Brandt, G.S.; Kneen, M.M.; Yep, A.; McLeish, M.J.; Kenyon, G.L.; Petsko, G.A.; Ringe, D.; Jordan, F.
Biochemistry
48
981-994
Perturbation of the monomer-monomer interfaces of the benzoylformate decarboxylase tetramer
2014
Andrews, F.H.; Rogers, M.P.; Paul, L.N.; McLeish, M.J.
Biochemistry
53
4358-4367
Links to other databases for (E)-2-oxo-4(pyridin-3-yl)-3-but-3-enoic acid